Disclosed are dielectric cavity arrays with cavities formed by pairs of dielectric tips, wherein the cavities have low mode volume (e.g., 7*10.sup.−5λ.sup.3, where X is the resonance wavelength of the cavity array), and large quality factor Q (e.g., 10.sup.6 or more). Applications for such dielectric cavity arrays include, but are not limited to, Raman spectroscopy, second harmonic generation, optical signal detection, microwave-to-optical transduction, and as light emitting devices.

The present invention relates to a nanoplasmonic biosensor capable of label-free multiplex detection of disease markers in blood with high selectivity and sensitivity and a method for detecting disease markers using the nanoplasmonic biosensor. The nanoplasmonic biosensor of the present invention enables label-free multiplex detection of miRNAs as disease markers in blood with high selectivity and sensitivity. Therefore, the nanoplasmonic biosensor of the present invention can be effectively used for the diagnosis of miRNA-related diseases and clinical applications.

A method for manufacturing glass-based micro- and nanostructure comprising the step of dewetting a thin-film glass layer on a textured substrate to form the micro- and nanostructure from the thin-film glass layer.

The Nondestructive Fluid Sensing System is a device that rapidly scans fluids to determine physical and chemical properties of the sample fluid. The Nondestructive Fluid Sensing System can detect the presence of a sample fluid with various optical and electrical sensors, and determines physical and chemical properties. The system features several innovations that increase sample throughput, reduces sample cross contamination, and eliminates waste products typically used in chemical tests. The system may be applied to various industries including manufacturing quality control, and healthcare.

Highly sensitive assays for pathogen detection, identification and/or analysis including, but not limited to, sensing of metabolite patterns associated with high-risk drug resistance phenotypes.

Object: To provide a remote substance identification device that can identify an unidentified substance, such as a harmful substance, from a remote location. Solution: Provided are a remote substance identification device and method, the device comprising a laser device 10 that emits a laser beam to an irradiated space; a wavelength conversion device 20 that converts a wavelength of the laser beam emitted from the laser device into a plurality of different wavelengths and that emits laser beams of the different wavelengths to the irradiated space; a light collecting-detecting device 30, 40, 50 that collects and detects resonance Raman-scattered light generated from an irradiated object due to resonance Raman scattering; and a processor 60 that identifies the irradiated object on the basis of a result detected by the collecting-detecting device 30, 40, 50.

An analysis device and an analysis apparatus for identification of analytes in fluids applying the SERS effect which provides a safe way to perform analysis, avoiding an accidental cross-contamination without the use of disinfectant products; the analysis device comprising a casing enclosing a sample region for receiving a fluid sample, and a nanoparticle region for storing at least a nanoparticle fluid; the sample region and the nanoparticle region being in fluid communication each other through a passage; driving means in fluid communication with the passage; a mixing region in fluid communication with the passage; and the casing being adapted to allow an incident monochromatic light from an external source to strike on the mixing region, and a reflected light from the mixing region to leave the casing.

Systems, methods, and modules for detecting a biomarker in a sample are described. A system for detecting presence or absence of a biomarker in a sample includes: a light source for producing electromagnetic radiation for interrogating the sample; a biosensor module including: a waveguide for guiding the electromagnetic radiation, the waveguide exposed to the sample; and a recognition element affixed to the waveguide and configured to bind to the biomarker; a detector for receiving the electromagnetic radiation from the waveguide and detecting a signal corresponding to an interaction of the electromagnetic radiation with the biomarker bound to the recognition element, in accordance with at least one detection modality; and a computing device for analyzing data related to the signal in order to detect presence or absence of the biomarker in the sample.

A portable system is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit and a housing arranged to hold the sampling unit, the sampling unit is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing has at least one inlet for the subject to exhale into the housing to the sampling unit and at least one outlet for the exhaled breath to exit through.

Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.