The present invention provides a biomolecule image sensor in which detection molecules are deposed on a light receiving surface of an image sensing element, and method thereof for detecting biomolecule.

A measurement device includes mechanical support elements (101-104) for supporting a sample well, other mechanical support elements (105-109) for supporting a measurement head (112) suitable for optical measurements, and a control system (111) configured to control the measurement head to carry out at least two optical measurements from at least two different measurement locations inside the sample well, where each measurement location is a center point of a capture range from which radiation is captured in the respective optical measurement. The final measurement result is formed from the results of the at least two optical measurements in accordance with a pre-determined rule. The use of the at least two optical measurements from different measurement locations reduces measurement variation in situations where the sample well (153) contains a piece (158) of sample carrier.

A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.

A blood coagulation analyzer and analyzing method perform following: (a) preparing a measurement specimen by dispensing a blood specimen and a reagent into a reaction container; (b) emitting light of a plurality of wavelengths to the measurement specimen in the reaction container, the wavelengths comprising a first wavelength for use in a measurement by a blood coagulation time method, and at least one of a second wavelength for use in a measurement by a synthetic substrate method and a third wavelength for use in a measurement by an immunoturbidimetric method; (c) detecting light of a plurality of wavelengths corresponding to the light emitted in (b), from the measurement specimen, by a light receiving element, and acquiring data corresponding to each wavelength; and (d) conducting an analysis based on the data corresponding to one of the wavelengths among the acquired data, and acquiring a result of the analysis.

A microplate reader includes a plurality of sets of: a light emitting portion disposed on one side of a microplate and corresponding to one well of the microplate; a light receiving portion disposed on an opposite side to the light emitting portion across the microplate and corresponding to one well of the microplate; and a light receiving light guide path disposed between the light receiving portion and the microplate and guiding light emitted from the light emitting portion and passing through a sample contained in the well to the light receiving portion. The microplate reader further includes a light guiding section configured to enclose a plurality of the light receiving light guide paths by an enclosure member made of a pigment-containing resin containing a pigment having a light-absorbing property. Light emitted from one light emitting portion passing through one light receiving light guide path and reaching one light receiving portion.

A test device includes a specimen having a circular cross section that accommodates a test target, a specimen holding part that holds a plurality of the specimens in a row, light emitting elements in which light is incident on two adjacent specimens among the plurality of specimens, a first light guide path 46 that guides light emitted by the light emitting elements, and a second light guide path that is formed to have a smaller diameter than a diameter of the first light guide path and that guides the light emitted by the light emitting elements from the first light guide path to the specimen.

A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.

Systems and methods for culturing and/or analyzing cells are provided. The system can include a microfluidic layer, a multi-well grid layer and a base layer. An electrode layer can optionally be provided. The system can also include an alignment feature for aligning microchannels of the microfluidic layer with electrodes of the electrode layer to achieve a predetermined organized architecture of the microchannels relative to the electrodes. The system can include a plurality of microfluidic layers and a microfluidic layer engaging frame engageable with the plurality of microfluidic layers to form a unitary structure engageable with a multi-well plate comprising a plurality of wells each comprising an electrode layer. A well identification feature associated with a microfluidic unit can be provided on an upper surface of the multi-grid layer to enable visual identification of a well of the multi-well grid layer that is in fluid communication with a microfluidic unit.

A bioassay device includes a main body, a biomolecular image sensor and an electrical connection portion. The main body is formed with a sensor groove. The biomolecular image sensor is disposed in the sensor groove and includes an image sensor unit. The electrical connection portion is disposed at one side of the main body and electrically connected to the biomolecular image sensor. Such that, all of the units in bioassay are able to be disposed on the main body, and the bioassay device is a kit for bioassay.