Apparatus for performing multiple different measurements on a small specimen sample, enabling testing and diagnoses in real time at the point of care are described. The core of the apparatus includes an ultrasonic resonator cavity where acoustic resonances are used to determine the speed of sound and sound attenuation in a single droplet. Acoustic measurements are made in the reflection mode using electrical impedance of a small piezoelectric crystal transducer that operates in the thickness longitudinal mode. Combination of this technology with electromagnetic, electrical, and magnetic fields permits multiple types of measurements to be made using the same resonator cavity.

A system includes a sensor comprising a sensor bonding layer disposed on a surface of the sensor, wherein the sensor bonding layer is a metallic alloy. An inlay includes a planar outer surface, wherein the inlay may be disposed on a curved surface of a structure. A structure bonding layer may be disposed on the planar outer surface of the inlay, wherein the structure bonding layer is a metallic alloy. The sensor bonding layer is coupled to the structure bonding layer via a metallic joint, and the sensor is configured to sense data of the structure through the metallic joint, the structure bonding layer, and the sensor bonding layer. The inlay comprises at least one of a modulus of elasticity, a shape, a thickness, and a size configured to reduce strain transmitted to the sensor.

The present disclosure provides molecularly imprinted polymers (MIPs) for selectively binding one or more viruses of a target viral genus, for example SARS-CoV-2, as well as methods of manufacture and uses thereof.

An apparatus is provided for airborne pathogen detection, which includes a crystal microbalance. The apparatus includes specific capture probes that are affixed to the crystal microbalance and are designed to bind to and capture a specific pathogen, such as a virus particle. This capture causes a change in mass of the crystal microbalance that can be detected. A method is provided for airborne pathogen detection, which includes calibrating a resonant frequency of the crystal microbalance to a mass on the crystal microbalance. The method also includes a step of conjugating the antibody to the crystal microbalance. The method also includes, for each measurement time, measuring a resonant frequency of the crystal microbalance and determining a mass change due to binding of the pathogen to the detector. This mass change is then related to pathogen load in the medium. A notification is output if the viral load exceeds a predetermined threshold.

A system and method for monitoring a semiconductor process includes a plurality of sensors and a microcontroller. The plurality of sensors are disposed within a process chamber. The microcontroller receives data from the plurality of sensors and measures the uniformity of a semiconductor process based on the data received from the plurality of sensors.

A quartz crystal microbalance (QCM) sensor includes a crystal plate, a buffer layer, and an electrode. The crystal plate has a first surface and a second surface. The second surface is opposite the first surface. The buffer layer includes a first buffer layer and a second buffer layer. The first buffer layer is disposed on the first surface of the crystal plate. the second buffer layer is disposed on the second surface of the crystal plate. The electrode includes a first electrode and a second electrode. The first electrode is disposed on the first buffer layer. The second electrode is disposed on the second buffer layer. The electrode includes at least one of titanium, scandium, beryllium, cobalt, yttrium, zirconium, technetium, ruthenium, lanthanum, cerium, praseodymium, neodymium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, lutetium, hafnium, rhenium, osmium, americium, curium, berkelium, and californium.

Various embodiments of an apparatus for measuring binding kinetics of an interaction of an analyte material present in a fluid sample are disclosed. The apparatus includes a sensing resonator having at least one binding site for the analyte material; actuation circuitry adapted to drive the sensing resonator into an oscillating motion; measurement circuitry coupled to the sensing resonator and adapted to measure an output signal of the sensing resonator representing resonance characteristics of the oscillating motion of the sensing resonator; and a controller coupled to the actuation and measurement circuitry, wherein the controller is adapted to detect an individual binding event between the at least one binding site and a molecule of the analyte material.

A surface acoustic wave sensor in which instrument drift resulting from accumulated surface contamination is minimized. The sensor includes a piezeoelectric substrate defined by an outer surface and a plurality of interdigitated electrodes mounted thereon. The electrodes are defined by one or more exposed portions and an unexposed portion abutting the outer surface of the piezoelectric substrate. An inert coating layer on the outer surface of the piezoelectric substrate and the exposed portions of the electrodes is provided, and can be a perfluoro-silane type compound, a perfluoro-trichloro-silane type compound, a perfluoro-acrylate type compound, polytetrafluoroethylene, or heptadecafluorodecyltrimethoxysilane.

A sensing device is provided that has satisfactory sensing accuracy when a crystal unit where an excitation electrode is formed on both upper and lower surfaces of a piezoelectric piece is used to sense a sensing object. Adsorption regions are arranged in two places so as to intersect a direction of flow of a fluid, thus each of the adsorption regions senses the sensing object and reference regions are individually provided in these adsorption regions. A difference Δf1 between the oscillation frequencies of the regions and a difference Δf2 between the oscillation frequencies of the regions are added, and based on the result of the addition, whether the sensing object is present or not and its concentration are detected.

One side of the surfaces of the crystal resonator 4 including an adsorbing film 46 that absorbs a sensing object on an excitation electrode 42A is pressed with the channel forming member 5 using the upper-side cover body 21 to fonn a channel 57, which runs from one end side to the other end side on one side of surfaces of the crystal resonator 4. A depressed portion 84 is disposed in at least one of: a position opposed to the channel 57 and at a surface on an opposite side of the channel 57 in the channel forming member 5, and a position opposed to the channel 57 and at a surface on the opposite side of the channel 57 in the pressing member with respect to the channel forming member 5.