A fluid processing apparatus includes a first fluid separation apparatus including a first fluid pump, configured for driving a first mobile phase, and a first separation unit configured for separating a fluidic sample when within the first mobile phase. A sampling unit includes a modulation buffering unit and a modulation drive, wherein the modulation drive is configured for introducing fluid into the modulation buffering unit. A switching unit is configured, in a first switching state, for introducing fluid into the modulation buffering unit from downstream of the first separation unit, and, in a second switching state, for introducing fluid buffered in the modulation buffering unit in a first flow path between the first fluid pump and the first separation unit.

A fluid modulator includes a fluid manifold, fluid valve, and pressure/flow controller. The manifold may include a primary tee, exhaust tee, secondary tee, loop conduit, and joining tube. The valve may include a common port, normally-open output port connected to the secondary tee, and normally-closed output port connected to the primary tee. The controller may be configured to provide auxiliary fluid to the common port. In embodiments, the primary tee, exhaust tee, and secondary tee are configured with the primary tee and secondary tee situated at ends of the fluid manifold and the exhaust tee disposed therebetween. In other embodiments, the exhaust tee, the primary tee, and the secondary tee are distributed in a linear fashion with the exhaust tee and secondary tee situated at ends of the fluid manifold and the primary tee disposed therebetween. An embodiment with a single, unitary 5-port fluid manifold is also disclosed.

A gas chromatograph that includes a metering chamber, two separating devices and a multiport valve unit having switching functions for metering, straight separation, cutting and backflush, where the multiport valve unit is formed as a multiport diaphragm valve.

The present invention is a data-processing device used for a chromatograph which continuously performs a series of analyses for components in each sample while sequentially introducing a plurality of samples into a column. The device includes: an input section configured to allow for input of information into a schedule table for a plurality of analyses, the schedule table describing an analysis condition including a combination of the values of a plurality of control parameters, the order of execution of the plurality of analyses, and information for identifying a sample to be subjected to each analysis; a chromatogram creating means configured to receive data sequentially collected during two or more analyses and create a joint chromatogram from the data if the two or more analyses have been continuously performed for the same sample according to the schedule table; and a display means configured to display the joint chromatogram.

An analysis device having a liquid chromatograph prevents a plurality of streams from being unusable at the same time Whether a usable stream is 0 or not among streams 1, 2, and 3 is determined. In a case where none of the streams is usable, the control unit skips a sample introduction in the cycle; and where there is one usable stream in the cycle, the stream is used. In a case where there are multiple streams that are usable in the cycle, and there are multiple streams of which the remaining number of uses of a separation column is the minimum, the stream having the smallest stream number is used; and where there is one stream of which the remaining number of uses of a separation column is the minimum, the stream to which the separation column having the minimum remaining number of uses is connected and used.

An analysis device having a liquid chromatograph prevents a plurality of streams from being unusable at the same time Whether a usable stream is 0 or not among streams 1, 2, and 3 is determined. In a case where none of the streams is usable, the control unit skips a sample introduction in the cycle; and where there is one usable stream in the cycle, the stream is used. In a case where there are multiple streams that are usable in the cycle, and there are multiple streams of which the remaining number of uses of a separation column is the minimum, the stream having the smallest stream number is used; and where there is one stream of which the remaining number of uses of a separation column is the minimum, the stream to which the separation column having the minimum remaining number of uses is connected and used.

The present invention relates to a valve unit (100) for a chromatography apparatus, the valve unit comprising a fluid inlet (110) configured to receive an input fluid, a fluid outlet (120) configured to provide an output fluid, a first pair of fluid ports (131,132) configured to be coupled to a first column, a second pair (141,142) of fluid ports configured to be coupled to a second column, a coupling valve assembly (200) configured to direct fluid between a selection of the fluid inlet (110), the fluid outlet (120), the first pair of fluid ports (131,132) and the second pair of fluid ports (141,142) in response to one or more control signals, wherein the coupling valve assembly is configured to direct fluid using a selection of membrane valves coupled by fluid channels comprised in a body of the coupling valve assembly. The invention further relates to a chromatography apparatus comprising the valve unit and a membrane valve comprised in the valve unit.

A chromatography column for the use of separation of acidic sugar chains, wherein the column comprises a first column and a second column, the second column connected by a flow path downstream of an outlet of the first column, and selected from the following (1) or (2): (1) the carrier of the first column is hydrophobically modified silica having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine; (2) the carrier of the first column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is hydrophobically modified silica having a group containing a primary amine, a secondary amine, or/and a tertiary amine.

A chromatography column for the use of separation of acidic sugar chains, wherein the column comprises a first column and a second column, the second column connected by a flow path downstream of an outlet of the first column, and selected from the following (1) or (2): (1) the carrier of the first column is hydrophobically modified silica having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine; (2) the carrier of the first column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is hydrophobically modified silica having a group containing a primary amine, a secondary amine, or/and a tertiary amine.

The disclosed system and method improve measurement of trace volatile chemicals, such as by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GCMS). A first trapping system can include a plurality of capillary columns in series and a focusing column fluidly coupled to a first detector. The first trapping system can retain and separate compounds in a sample, including C3 hydrocarbons and compounds heavier than C3 hydrocarbons (e.g., up to C12 hydrocarbons, or compounds having a boiling point around 250° C.), and can transfer the compounds from the focusing column to the first detector. A second trapping system can receive compounds that the first trapping system does not retain, and can include a packed trap and two columns. The second trapping system can remove water from the sample and can separate and detect compounds including C2 hydrocarbons and Formaldehyde.