A purification system for separating a molecule of interest from a solution is provided and generally includes a plurality of resin processing sections, wherein each of the resin processing sections is controllably separated from each other via a configurable gate valve, wherein the configurable gate valve is configured to introduce or evacuate a fluid/resin into/out of a proximately located processing section, a plurality of inlets configured to introduce fluid and/or resin into one or more of the plurality of resin processing sections.

A device for separating one or more molecules of interest in a liquid specimen including a monolithic body defining a fractionation column. The column includes an inlet opening at a proximal end of the fractionation column; an outlet opening at a distal, opposite end of the fractionation column; a solid phase chamber positioned between the inlet opening and the outlet opening; a specimen introduction area adjacent a proximal end of the solid phase chamber; an analyte exit area adjacent a distal end of the solid phase chamber; an inlet chamber adjacent the inlet opening that tapers into the specimen introduction area; and an outlet chamber that extends from the analyte exit area to the outlet opening. A metered amount of solid phase packed within the solid phase chamber between a first porous frit and a second porous frit of the solid phase chamber.

A chemical reactor is implemented on a substrate and has an inlet for receiving a fluid and/or a gas; a filter element for reducing or preventing that materials cause a blockage in the fluid supplied and/or the gas supplied in a part of the chemical reactor located further away; and a part located further away for transporting and/or processing the fluid and/or the gas. The part located further away has a depth dlow smaller than the depth dhigh of the inlet. The filter element has a first duct part and a second duct part; the first duct part is positioned closer up against the inlet than the second duct part, the first duct part is deeper than the second duct part, the first duct part has a diverging width and is free from pillar structures, and the second duct part is filled with filter pillars.

An apparatus for chemical separations includes a first substantially rigid microfluidic substrate defining a first fluidic port; a second substantially rigid microfluidic substrate defining a second fluidic port; and a coupler disposed between the first and second substrates, the coupler defining a fluidic path in fluidic alignment with the ports of the first and second substrates. The coupler includes a material that is deformable relative to a material of the first substrate and a material of the second substrate. The substrates are clamped together to compress the coupler between the substrates and form a fluid-tight seal.

A medical separation device, its production, and its use are provided, wherein the device has a hollow cylindrical housing sealed at its top and bottom sides, wherein the device has an outer wall, a fluid inlet, and a fluid outlet, and wherein the device has a filling connection for a separation medium arranged tangentially to, and inside of, the cylindrical housing outer wall for filling the device with a separation medium.

A cylindrical column body (101) holds a filler. A pair of end caps (105, 106) covers both ends of the column body (101) and has a flow hole for a carrier liquid (111, 112) arranged in the center thereof. An end surface on the side of a large diameter portion (113a, 114a) of a pair of columnar joint members (113, 114) contacts an end surface of the pair of end caps (105, 106) and also has a communication hole (115, 116) arranged in the center thereof. A sealing member (117, 118) is arranged on a contact surface between the end cap (105, 106) and the joint member (113, 114). A bottomed cylindrical case (121) accommodates the pair of end caps (105, 106) and a large diameter portion of the pair of joint members (113, 114) in an engaged state. A cover member (124) is detachably installed on a side of an opening of the case (121).

A chromatography and synthesis column that includes a main tube, a plurality of lower media ports, and an internal groove. The internal groove is formed in an interior surface of the main tube and selectively provides an internal flow path between each of the internal lower media ports. This, in turn, facilitates quick and easy maintenance of the internal lower media ports and other components of the chromatography and synthesis column.

In this invention, chromatography is integrated on a centrifugal platform to enable low-cost automated purification. Differing from the traditional chromatography method, purification and separation of a centrifugal compound collecting platform disclosed in the present invention mainly uses a centrifugal force to drive the fluid to flow outward in the radial direction when the motor rotates. The compounds to be separated react with the column packing during the flow, and the compounds with different polarities in the sample are gradually separated. The flow of the fluid can be governed by the motor and the geometry of the fluidic design such that compounds with different characteristics can be separated and collected in different collecting chambers.

A connection assembly for a chromatograph is used for connection to a flow path of the chromatograph, and includes a tube, a housing and a ferrule. The housing has an opening into which an end portion of the tube forming the flow path is insertable. The ferrule is formed of resin having chemical resistance and holds the tube in the opening of the housing while surrounding the tube. The ferrule has an inner peripheral surface coming into contact with the tube and an outer peripheral surface coming into contact with the housing. The friction coefficient between the inner peripheral surface of the ferrule and the tube, and the friction coefficient between the outer peripheral surface and the housing are equal to or larger than 0.3.

The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste.