A gas chromatography guard column assembly is disclosed including a guard column having an inlet and an outlet. The guard column is disposed in a coil having a column coil aspect ratio of less than 15. A gas chromatography system is disclosed including an oven cavity, a heater assembly, an inlet, a guard column, an analytical column, and a detector. The guard column is in fluid communication with the inlet and is disposed in a guard column coil. The analytical column is in fluid communication with the guard column and is disposed in an analytical column coil. The detector is in fluid communication with the analytical column. The analytical column coil has an analytical column coil central axis aligned with a central axis of the heater assembly, and the guard column coil has a guard column coil central axis remote from the central axis of the heater assembly.

A device for separating one or more molecules of interest in a liquid specimen including a monolithic body defining a fractionation column. The column includes an inlet opening at a proximal end of the fractionation column; an outlet opening at a distal, opposite end of the fractionation column; a solid phase chamber positioned between the inlet opening and the outlet opening; a specimen introduction area adjacent a proximal end of the solid phase chamber; an analyte exit area adjacent a distal end of the solid phase chamber; an inlet chamber adjacent the inlet opening that tapers into the specimen introduction area; and an outlet chamber that extends from the analyte exit area to the outlet opening. A metered amount of solid phase packed within the solid phase chamber between a first porous frit and a second porous frit of the solid phase chamber.

Provided herein is a valve manifold comprising (a) an elastomer sheet attached to a plurality of magnetic pistons, wherein the magnetic pistons project from a first side of the elastomer sheet; (b) a foot component comprising a first surface and a plurality of shafts that orthogonally pass through the first surface; and (c) a body component comprising a second surface, a groove that laterally passes along the second surface, and a plurality of reservoir channels that orthogonally pass through the second surface, wherein the elastomer sheet is compressed between the foot component and the body component.

A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

A chromatography device (201; 201′) comprising: – at least one chromatography material unit (203), wherein said chromatography material unit comprises a convection-based chromatography material and is of a substantially rectangular shape having a length (L) and a width (W); - at least one fluid distribution system (207) which is configured to distribute fluid into and out from the at least one chromatography material unit (203), wherein said fluid distribution system (207) comprises a distribution device (209a) and a collection device (209b) between which said chromatography material unit (203) is sandwiched, wherein said distribution device (209a) and said collection device (209b) each comprises a number of parallel grooves (255) for distribution and collection respectively of a fluid to be passed through the chromatography material unit (203), wherein said parallel grooves are reaching over substantially the whole length (L) of the chromatography material unit (203) and are distributed over substantially the whole width (W) of the chromatography material unit (203).

A sample cartridge for a liquid chromatography device includes a microfluidic chip. A collector in the microfluidic chip includes a collector flow channel and a first window for acquisition of spectral data from a sample in the collector flow channel.

A method of making Lu-177 involving dissolving enriched Yb.sub.2O.sub.3, loading dissolved enriched Yb.sub.2O.sub.3 on a first guard column containing resin prepared from (2-ethyl-1-hexyl)phosphonic acid mono(2-ethyl-1-hexyl)ester (HEH[EHP]), passing a first separation of a stream exiting from first guard column through a first resin cartridge containing dipentyl pentylphosphonate, collecting Lu-177 onto a first collection column having resin containing tetraoctyl diglycolamide (DGA), loading an exiting stream from first collection column on a second guard column containing resin prepared from (2-ethyl-1-hexyl)phosphonic acid mono(2-ethyl-1-hexyl)ester (HEH[EHP]); passing a first separation of a stream exiting from second guard column through a second resin cartridge containing dipentyl pentylphosphonate; collecting Lu-177 onto a second collection column having resin containing DGA; passing a second separation of a stream exiting from second guard column through a third resin cartridge containing dipentyl pentylphosphonate; and collecting Lu-177 having passed through the third resin cartridge onto a third collection column having resin containing DGA.

A detection cassette for detecting a sample is provided. The sample includes a first component and a second component. The detection cassette includes a sample injection hole, first and second separation tanks communicated with the sample injection hole, and first and second detection tanks communicated with the first and second separation tanks. A part of the sample enters the first separation tank from the sample injection hole and separated into the first component and the second component in the first separation tank. Another part of the sample enters the second separation tank from the sample injection hole and separated into the first component and the second component in the second separation tank. The first component separated in the first separation tank flows to the first detection tank and the second component separated in the second separation tank flows to the second detection tank for detections. A detection system is provided.

A liquid chromatography column, utilizing horizontal or radial flow of sample material passing there through, includes a housing defining a chamber therein, at least one removable screw lid, and first and second longitudinally extending porous frits positioned within the chamber. A bed or packing of particulate, chromatographic separation material is positioned within the chamber and intermediate the porous frits, the first of the porous frits being adjacent the housing and an inlet channel, the second of the porous frits being positioned adjacent a core member and an outlet channel. A distributor is operatively connected to the inlet channel, and a collector is connected to the outlet channel. The distributor and the inlet channel are constructed to direct associated material to be separated in the bed evenly across a longitudinal length of the bed in a horizontal direction.