A hybrid device comprising Metal Oxide Sensors in a Gas Chromatography column is described, whereby the readings from the MOS devices will vary along the column in reaction to the sample reflecting the differential delays imposed on the components of the sample depending on the elutive effect of the adsorbent lining the column for the respective component. By this means, a family of readings is obtained, any one of which may be easier to interpret for a particular sample, and which may be compared amongst themselves providing an additional measurement dimension. The behaviour of later sections of column or sensors may be modified dynamically during a measurement cycle depending on the readings obtained at the earlier stages.

Automated systems and methods for obtaining of the concentration of impurities in a liquid ethylene oxide product stream are shown and described. The systems and methods employ remote injection and flash vaporization of small volumes of liquid ethylene oxide into a carrier gas to minimize polymerization of the ethylene oxide and accumulation of polymerized ethylene oxide. Ethylene oxide peaks are diverted from the gas chromatograph effluent detector to stabilize baseline signal errors and avoid errors in the calculation of an impurity with an adjacent retention time peak. The systems and methods may be used for feedback, feedforward, dynamic matrix, and/or model-based predictive control of ethylene oxide purity. The systems and methods reduce lag times and errors associated with relying on laboratory analyses to make process adjustments.

Automated systems and methods for obtaining of the concentration of impurities in a liquid ethylene oxide product stream are shown and described. The systems and methods employ remote injection and flash vaporization of small volumes of liquid ethylene oxide into a carrier gas to minimize polymerization of the ethylene oxide and accumulation of polymerized ethylene oxide. Ethylene oxide peaks are diverted from the gas chromatograph effluent detector to stabilize baseline signal errors and avoid errors in the calculation of an impurity with an adjacent retention time peak. The systems and methods may be used for feedback, feedforward, dynamic matrix, and/or model-based predictive control of ethylene oxide purity. The systems and methods reduce lag times and errors associated with relying on laboratory analyses to make process adjustments.

The invention relates to a method for mass analysing a sample by ionising the sample to first sample ions and to second sample ions and by obtaining mass spectra from the first sample ions and the second sample ions with a mass analyser (5). Thereby, repeatedly, a first assay is obtained from the sample and transferred past any chromatography column to a first ion source (2) and ionised by the first ion source (2) to the first sample ions, wherein the first sample ions obtained from the respective first assay are transferred to the mass analyser (5), wherein at least one first mass spectrum is obtained with the mass analyser (5) from the first sample ions obtained from the respective first assay and ionised by and transferred from the first ion source (2). Furthermore, at least once, a second assay is obtained from the sample within a time window being associated with the respective second assay and having a window width, wherein the respective second assay is transferred for chromatographic separation via a chromatography column (3) to at least one second ion source (4.1, 4.2) in that after being chromatographically separated, the respective second assay eluting from the chromatography column (3) is transferred to the at least one second ion source (4.1, 4.2) and ionised by the at least one second ion source (4.1, 4.2) to the second sample ions, wherein the second sample ions obtained from the respective second assay are transferred to the mass analyser (5), wherein at least one second mass spectrum is obtained with the mass analyser (5) from the second sample ions obtained from the respective second assay which has been ionised by and transferred from the at least one second ion source (4.1, 4.2). Thereby, each one of the at least one second mass spectrum is assigned to one or more of the at least one first mass spectrum from the first sample ions obtained from one of the first assays which has been obtained from the sample within the time window associated with the respective second assay which has been chromatographically separated and ionised by the at least one second ion source (4.1, 4.2) to the second sample ions from which the respective one of the at least one second mass spectrum has been obtained. Furthermore, the invention relates to an apparatus (1) for mass analysing a sample with the method according to the invention.

A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas mixture, the detection mechanism including at least one detector of nanosensor type of an outlet of the column and a detector of nanosensor type in the column, capable of detecting passage of the compounds. It is then possible to determine the velocity of each of the compounds within the system.

A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas mixture, the detection mechanism including at least one detector of nanosensor type of an outlet of the column and a detector of nanosensor type in the column, capable of detecting passage of the compounds. It is then possible to determine the velocity of each of the compounds within the system.

An analysis data processing method for processing analysis data collected with an analyzing device for each of a plurality of samples, by applying an analytical technique using statistical machine learning to multidimensional analysis data formed by output values obtained from a plurality of channels of a multichannel detector provided in the analyzing device, the method including: acquiring a non-linear regression or non-linear discrimination function expressing analysis data obtained for known samples; calculating a contribution value of each of the output values obtained from the plurality of channels forming the analysis data of the known samples, to the acquired non-linear regression or non-linear discrimination function, based on a differential value of the non-linear regression function or non-linear discrimination function; and identifying one or more of the plurality of channels of the detector, which are to be used for processing analysis data obtained for an unknown sample, based on the contribution value.

An analysis data processing method for processing analysis data collected with an analyzing device for each of a plurality of samples, by applying an analytical technique using statistical machine learning to multidimensional analysis data formed by output values obtained from a plurality of channels of a multichannel detector provided in the analyzing device, the method including: acquiring a non-linear regression or non-linear discrimination function expressing analysis data obtained for known samples; calculating a contribution value of each of the output values obtained from the plurality of channels forming the analysis data of the known samples, to the acquired non-linear regression or non-linear discrimination function, based on a differential value of the non-linear regression function or non-linear discrimination function; and identifying one or more of the plurality of channels of the detector, which are to be used for processing analysis data obtained for an unknown sample, based on the contribution value.

The present invention relates to a chromatography system and a method therefor. The chromatography system comprising an inlet port (102) for receiving a sample, an outlet port (106) for delivering the sample, a detector (201), a column (104), and a valve (202) in fluid communication with the inlet port, the outlet port, the detector, and the column. The valve (202) comprises a first position (304) wherein the inlet port is in fluid communication with the outlet port via a first fluid path comprising the detector and the column, wherein the detector is arranged upstream the column. The valve comprises a second position (404) wherein the inlet port is in fluid communication with the outlet port via a second fluid path comprising the detector and the column, wherein the detector is arranged downstream the column.

The present invention relates to a chromatography system and a method therefor. The chromatography system comprising an inlet port (102) for receiving a sample, an outlet port (106) for delivering the sample, a detector (201), a column (104), and a valve (202) in fluid communication with the inlet port, the outlet port, the detector, and the column. The valve (202) comprises a first position (304) wherein the inlet port is in fluid communication with the outlet port via a first fluid path comprising the detector and the column, wherein the detector is arranged upstream the column. The valve comprises a second position (404) wherein the inlet port is in fluid communication with the outlet port via a second fluid path comprising the detector and the column, wherein the detector is arranged downstream the column.