The present invention provides an apparatus for detecting the presence or absence of an analyte in liquid sample, including: a collection chamber, including an opening for collecting a liquid sample; a testing element for testing the analyte in liquid sample; and a cover for covering the opening of the collection chamber; wherein the apparatus further includes a prompting device for prompting if the cover is covered to a specified location, and the prompting device shall at least includes a first element and a second element, the first element is in contact with the second element, wherein one element vibrates to produce a sound. In some preferred ways, the second element produces friction with the first element, to cause one of the elements to generate vibrations. The apparatus in the present invention can allow the prompting sound to be clear and loud.

A sensor may include a prism having a first face; a metal first layer covering, via a contact face, the first face; a light source; and a matrix-array detector; the device may include a dielectric second layer on which rests a transistor including a sheet made of a two-dimensional material, intended to form a channel region, a front face of the sheet comprising a specific functionalization via which specific targets are liable to be adsorbed, the specific functionalization being suitable for placing the adsorbed specific targets at a smaller distance Dd below which detection via electrical measurement by means of the specific transistor and via measurement of resonance of surface plasmons is possible.

The subject invention provides materials and methods for single-step detection of target molecules in a sample. The methods and assays of the subject invention employ a dye-displacement strategy, in which aptamers complexed with a cyanine dye for sensitive and rapid detection of targets of interest. In the presence of a target, aptamer-target binding liberates the non-covalently bound aptamer-binding dye, resulting in optical changes that can be observed spectrophotometrically or with the naked eye. The methods and assays of the subject invention enable the colorimetric detection of targets of interest regardless of their structure, sequence, target-binding affinity, and physicochemical properties of their targets.

A test strip includes a substantially transparent substrate and one or more colorimetric test spots on the transparent substrate. Each colorimetric test spot has one or more sensing chemicals chemically attached onto a porous support material. The porous support material has at least one exposed surface configured to absorb a body fluid. The one or more sensing chemicals are configured to change a color in response to a presence of a target drug in the body fluid.

Described herein are the amphetamine-related compounds amphetamine carbamate (amphetammonium-amphetacarbamate) and amphetacarbamate, methods of making them, methods for detecting or quantitatively determining the amount of amphetacarbamate or amphetamine carbamate in a compositions, and ion chromatography columns useful in such methods.

The present invention relates to a method and system for obtaining an interaction property between a molecule or biomolecule or particle or bioparticle or nano- or microparticle on the one hand and a target particle on the other hand. The method comprises obtaining potentiometric titration results for a potentiometric measurement during titration of a solution with a titrant, said solution being a solution of one of a ligand of the target particle or said molecule or biomolecule or particle or bioparticle or nano- or microparticle. Said titrant comprises the other of said target particle ligand or said molecule or biomolecule or particle or bioparticle or nano- or microparticle. The method also comprises deriving based on said potentiometric titration results an interaction property between said molecule or biomolecule or particle or bioparticle or nano- or microparticle and said target particle.

A source of formaldehyde for methylating a primary or secondary amine is part of an electrochemical measurement. The source of formaldehyde may be an adduct of formaldehyde.

The invention relates to an arylalkylamine, pyrrole, indole and opiate derivative concentration determination method and a test kit using said method for precise determination of the presence and precise concentration of said substances which have an indole as a structural element and similarly structured substances having primary amines or pyrrole compounds, phenylethylamines and other substances. The problem addressed by the invention of is that of providing an arylalkylamine, pyrrole, indole and opiate derivative concentration determination method and a test kit for concentration determination, which provide fast, low-cost and low-effort quantitative detection of indole derivatives, in particular of psilocybin, and of arylalkylamine, pyrrole or opiate derivatives and in so doing enable precise determination of the presence and precise concentrations of different natural substances, such as psilocybin, for example, which have an indole as a structural fragment, and similarly structured substances having primary or secondary amines or pyrrole compounds in a rapid test. Said problem is solved in that the method comprises two method steps in the form of an extraction step and a subsequent analysis step using a color reagent, wherein in the analysis step at least one color reagent having at least one arylalkyl, pyrrole, indole or opiate derivative causes a quantitative and linear color reaction which is measurable by means of colorimetric methods and which is detected and evaluated.

An oral fluid collection device is provided that includes a borosilicate glass collection tube that can be capped post-collection for containing a human donor's expectorated oral fluid. The collection tube has a lyophilized reagent disposed therein that is essentially free of surfactants and solvents and includes a bacteriostatic, a peptidoglycan cleaving enzyme, an esterase inhibitor, an antioxidant, and a buffer at a pH range of about 5.7 to about 6.5 for stabilizing drugs and drug metabolites that may be present in the donor oral fluid. Interaction between the collected oral fluid and the buffer-preservative is provided by gravity drawing the collected oral fluid downward into contact with the lyophilized buffer-preservative. The lyophilized buffer-preservative brings the collected oral fluid to a pH for stabilization of the drugs and drug metabolites including Δ.sup.9-tetrahydrocannabinol (THC), the major metabolite of THC, 11-nor-Δ.sup.9-tetrahydrocannabinol-9-carboxylic acid, (THCA), cocaine, and the major metabolite of cocaine, benzoylecgonine (BZE).

A detection platform is suitable for detecting an abused drug in a sample. The detection platform includes a sensing array, an image and transmission tool, and a remote workstation. The sensing array includes a reaction container, gold nanoclusters, carbon quantum dots, silver nanoclusters and a mixed solution after reaction with a Marquis reagent. The reaction container has a plurality of first grooves and a plurality of second grooves. The gold nanoclusters, the carbon quantum dots, the silver nanoclusters, and the mixed solution after reaction with the Marquis reagent are arranged in the corresponding first grooves and the corresponding second grooves, respectively. When the abused drug reacts with the gold nanoclusters, carbon quantum dots and silver nanoclusters in the first grooves, respectively, and the mixed solution after the abused drug reacting with the Marquis reagent is added to the second groove, a detection result is obtained.