The present invention generally pertains to methods of characterizing antibody higher order structure. In particular, the present invention pertains to the use of novel NMR methods to compare manufacturing process variability in antibody higher order structure.

Methods for determining a volume of stored gas within a rock sample includes loading a rock sample into an overburden cell. A hydrocarbon gas at a gas pressure is applied to the rock sample and a confining fluid at a confining pressure is applied to the overburden cell. The confining pressure and the gas pressure are increased until a first pressure and temperature condition is met. With the rock sample maintained at the first temperature and pressure condition, a nuclear magnetic resonance spectrometer is used to scan the rock sample and measure a hydrocarbon gas volume within the rock sample. This measured hydrocarbon gas volume is then corrected using a Real Gas Index to determine the volume of stored gas within the rock sample.

A method of determining patient responsiveness to a drug by the use of spectroscopy to obtain patient metabolite data and relating that data to data obtained from a statistically significant group of patients taking the same drug in order to obtain a result indicating responsiveness of a particular patient to treatment with a particular drug.

A device for NMR spectroscopy includes a magnet arrangement, configured to produce a magnetic probe field within a magnet field of view external to the magnet arrangement. In a embodiment, the device includes a coil arrangement, configured to generate an electromagnetic excitation field within a coil field of view and a controller, configured to control the coil arrangement. The device includes a magnet adjustment arrangement, configured and arranged to modify at least one parameter of the magnet arrangement to change a spatial position of the magnet field of view.

The present invention discloses a method of species identification and quality detection of liquid-like samples based on nuclear magnetic resonance technology. In this invention, a two-dimensional relaxation signal containing the .sup.1H T.sub.1 and T.sub.2 relaxation properties of liquid-like samples is obtained by applying a specially designed composite pulse sequence to liquid-like samples, and a fingerprint spectrum from this signal is established. The fingerprint spectrum can be associated with the essential characteristics of the tested sample, thus can be used to distinguish a specific liquid-like sample from the others. The fingerprint spectrum can be easily converted into a digital form, which is not only suitable for constructing big data of fingerprint spectrum for liquid-like samples, but also can be used for quality detection and authenticity judgment of liquid-like samples based on artificial intelligence. The present invention has the advantages of no need for sample pretreatment, non-destructive sample testing, convenience, quickness, excellent operability, good stability and reproducibility, etc., which can be used for species identification and quality detection of a variety of liquid-like samples, which has a wide application value.

The present disclosure provides a chemical bond evaluation method capable of directly evaluating the presence or absence of a chemical bond between silica and a silane coupling agent. Included is a chemical bond evaluation method including evaluating the presence or absence of a chemical bond between silica and a silane coupling agent in a rubber composition containing a rubber component, the silica, and the silane coupling agent.

A method for acquiring nuclear magnetic resonance (NMR) phase-sensitive two-dimensional (2D) J-resolved spectrum by suppressing strong coupling spurious peaks, comprising: 1) placing a sample, collecting a conventional one-dimensional (1D) spectrum of the sample, and measuring a time width (pw) of a 90° pulse, wherein the conventional 1D spectrum provides J coupling information and chemical shift information of the sample; and 2) introducing a pulse sequence for suppressing strong coupling, setting parameters of a chirp sweep frequency pulse, a pure shift yielded by chirp excitation (PSYCHE) module, and a J sampling module, and collecting and saving data of a spectrum.

A method for acquiring nuclear magnetic resonance (NMR) phase-sensitive two-dimensional (2D) J-resolved spectrum by suppressing strong coupling spurious peaks, comprising: 1) placing a sample, collecting a conventional one-dimensional (1D) spectrum of the sample, and measuring a time width (pw) of a 90° pulse, wherein the conventional 1D spectrum provides J coupling information and chemical shift information of the sample; and 2) introducing a pulse sequence for suppressing strong coupling, setting parameters of a chirp sweep frequency pulse, a pure shift yielded by chirp excitation (PSYCHE) module, and a J sampling module, and collecting and saving data of a spectrum.

Methods for determining a volume of stored gas within a rock sample includes loading a rock sample into an overburden cell. A hydrocarbon gas at a gas pressure is applied to the rock sample and a confining fluid at a confining pressure is applied to the overburden cell. The confining pressure and the gas pressure are increased until a first pressure and temperature condition is met. With the rock sample maintained at the first temperature and pressure condition, a nuclear magnetic resonance spectrometer is used to scan the rock sample and measure a hydrocarbon gas volume within the rock sample. This measured hydrocarbon gas volume is then corrected using a Real Gas Index to determine the volume of stored gas within the rock sample.

Systems and methods for analyzing metabolite concentration in a subject using a medical imaging system are provided. The method includes, using a nuclear magnetic resonance (NMR] system, acquiring data from a subject during multiple acquisitions using different echo times for the multiple acquisitions to create a chemical shift domain. The method also includes, using the chemical shift domain, identifying metabolites by at least two chemical shifts and generating a report indicating the metabolites.