Exemplary embodiments of the present invention relate generally to the fields for indicating a location on an image in a multi-viewer display. In particular embodiments, the multi-viewer display may be a multi-viewer microscope.

Systems and methods of imaging are described. An imaging system comprises a light source configured to projecting a beam of light; a first diffraction grating configured to separating wavelengths of the projected beam of light; a first lens configured to focusing the wavelengths of the projected beam of light projecting from separated by the first diffraction grating; a reticle configured to altering each wavelength of light focused by the first lens; a second lens configured to collimating the wavelengths of light projecting from altered by the reticle; a second diffraction grating configured to multiplexing the collimated light projecting from collimated by the lens; and a third lens configured to projecting the multiplexed light onto an object plane, wherein the multiplexed light is used to generate an image of an object in the object plane.

The invention provides an integrated digital microscope system comprising a camera, a lens and a screen to view an object characterised in that an integrated circuit comprises a video buffer write block, a grid generator block, and a video buffer read block configured to correct lens distortion errors in an image appearing on said screen. The invention also provides an integrated digital microscope system configured to remove chromatic distortion errors.

Laser emission based microscope devices and methods of using such devices for detecting laser emissions from a tissue sample are provided. The scanning microscope has first and second reflection surfaces and a scanning cavity holding a stationary tissue sample with at least one fluorophore/lasing energy responsive species. At least a portion of the scanning cavity corresponds to a high quality factor (Q) Fabry-Pérot resonator cavity. A lasing pump source directs energy at the scanning cavity while a detector receives and detects emissions generated by the fluorophore(s) or lasing energy responsive species. The second reflection surface and/or the lasing pump source are translatable with respect to the stationary tissue sample for generating a two-dimensional scan of the tissue sample. Methods for detecting multiplexed emissions or quantifying one or more biomarkers in a histological tissue sample, for example for detection and diagnosis of cancer, or other disorders/diseases are provided.

An auto-focusing system is disclosed. The system includes an illumination source. The system includes an aperture. The system includes a projection mask. The system includes a detector assembly. The system includes a relay system, the relay system being configured to optically couple illumination transmitted through the projection mask to an imaging system. The relay system also being configured to project one or more patterns from the projection mask onto a specimen and transmit an image of the projection mask from the specimen to the detector assembly. The system includes a controller including one or more processors configured to execute a set of program instructions. The program instructions being configured to cause the one or more processors to: receive one or more images of the projection mask from the detector assembly and determine quality of the one or more images of the projection mask.

A medical projection apparatus includes: a plurality of projectors each configured to project projection light onto an observation area of an observation optical system, wherein at least two or more projectors of the plurality of projectors are configured to respectively emit projection light to different planes including an optical axis of the observation optical system, and the projection light emitted by the two or more projectors cross each other in any position within a range of at least a possible working distance of the observation optical system.

An auto-focusing system is disclosed. The system includes an illumination source. The system includes an aperture. The system includes a projection mask. The system includes a detector assembly. The system includes a relay system, the relay system being configured to optically couple illumination transmitted through the projection mask to an imaging system. The relay system also being configured to project one or more patterns from the projection mask onto a specimen and transmit an image of the projection mask from the specimen to the detector assembly. The system includes a controller including one or more processors configured to execute a set of program instructions. The program instructions being configured to cause the one or more processors to: receive one or more images of the projection mask from the detector assembly and determine quality of the one or more images of the projection mask.

A viewing apparatus for producing a stereoscopic image for an observer, the viewing apparatus comprising: first and second video projectors for projecting respective ones of first and second video images of an object, the first and second images being different images which are one or both of spatially and angularly shifted in relation to the object so as to convey parallax between the images; a mirror arrangement comprising a concave mirror which receives light from the first and second video projectors, the mirror arrangement being located in relation to the first and second video projectors such that focussed images of the object are produced at the mirror arrangement; and a viewing lens for relaying exit pupils corresponding to each of the focussed images as reflected by the mirror arrangement to a viewing plane so as to be viewable at the respective eyes of the observer as a stereoscopic image without use of adapted eyewear; wherein the video projectors comprise first and second video displays which are driven by first and second video signals to display respective ones of the first and second video images, and first and second optical arrangements for focussing light from the respective images as displayed by the first and second displays to the mirror arrangement.

A microscope system includes: a microscope optical system including an ocular lens, the microscope optical system being configured to form an optical image of a sample on an object side of the ocular lens; a processor configured to generate, based on examination information regarding examination to the sample and magnification information regarding a magnification of the microscope optical system, image data of a comparative image for comparison with the optical image; and a superimposition device configured to superimpose, based on the image data generated by the processor, the comparative image onto an image plane on which the optical image is formed.

A microscopy system includes a microscope, a stand configured to mount the microscope and including a drive device configured to move the microscope, a detection device configured to detect a spatial position of a target fastened to a body part or to an instrument, wherein the position detection device includes the target with at least one marker element and an image capture device configured to optically capture the target. The microscopy system further includes at least one control device configured to operate the microscopy system according to the detected position of the target, wherein the position detection device is configured to determine the position of the target by evaluating a two-dimensional image of the image capture device. In addition, a method for operating the microscopy system is provided.