A lubricant replacement case for an image forming apparatus includes a housing including a plurality of storage compartments to accommodate at least one lubricant unit. The plurality of storage compartments include at least one storage compartment for unused lubricant to be inserted into the image forming apparatus and at least one storage compartment for used lubricant to be retrieved from the image forming apparatus.

An image forming apparatus, to which a replaceable unit with a nonvolatile memory is mounted, including: a storage portion configured to store data related to the replaceable unit read from the memory and hold stored contents even when the image forming apparatus is not activated; a door to be opened when the replaceable unit is replaced; a detector configured to detect whether the door is open or closed; a latch circuit configured to hold a specific state when the detector detects that the door is open when the image forming apparatus is not activated; and a controller configured to, when activating the image forming apparatus, read the data from the memory when the latch circuit is in the specific state, read the data from the storage portion when the latch circuit is not in the specific state, and perform an activation process based on the read data.

An image forming apparatus includes: a frame; a cover movable between a closed position and an open position; a fixing unit including a heating member and a pressure roller configured to form a nipping region therebetween; an adjustment mechanism configured to adjust a nipping pressure between the heating member and the pressure roller in conjunction with movement of the cover; and a link mechanism connected to both the adjustment mechanism and the cover. The adjustment mechanism includes an arm pressing the heating member such that the heating member and the pressure roller form the nipping region. The link mechanism includes: a first link connected to the cover; a second link connected to the first link and pivotally movable about an axis extending in a width direction; and a third link connected to both the second link and the adjustment mechanism. The third link is movable in a front-rear direction.

An image heating apparatus includes a first rotary member, a second rotary member, a frame member, a guide portion, and a cover. The first rotary member is configured to heat a toner image formed on a recording material. The second rotary member is configured to contact the first rotary member and form a fixing nip portion with the first rotary member. The frame member is configured to support the first rotary member and the second rotary member. The guide portion is configured to guide the first rotary member to be moved upstream in a conveyance direction of the recording material when the first rotary member is being removed. The cover is attached to the frame member and configured to turn around a rotation shaft to open and close the guide portion. The cover is configured to turn in a direction toward the conveyance direction to open the guide portion.

A first rotating member a heating recording medium, a second rotating member forming a nip portion with the first rotating member, a holding member disposed downstream of the nip portion in a conveying direction and holds a conveying member conveying the recording medium, and a guide member facing the conveying member, the fixing apparatus is not exposed to an outside when opening/closing member is in a closed state, the fixing apparatus is exposed to the outside when the opening/closing member is in an opened state. A distance between the holding member being in the closed state and at a first position and the guide member is a first distance. A distance between the holding member being in the opened state and at a second position and the guide member is a second distance, and the second distance is shorter than the first distance.

A heat roller includes a main body and a follower gear. The main body includes a cutaway portion and a pair of protruding plate portions. The follower gear includes a transmission protrusion and an abutment portion. The transmission protrusion is abutted against one protruding plate portion, when the follower gear rotates. The abutment portion is abutted against the one protruding plate portion, when the main body rotates in advance. A size of the transmission protrusion along the width direction of the cutaway portion is smaller than a clearance between the pair of protruding plate portions in the width direction, and a clearance between the abutment portion and the one protruding plate portion in the roller rotation direction is narrower than a clearance between the transmission protrusion and the other protruding plate portion in the roller rotation direction, when the transmission protrusion is in contact with the one protruding plate portion.

A humanized monoclonal antibody that binds to an advanced glycation end-product-modified protein or peptide on a cell comprises a heavy chain and a light chain. The antibody binds a carboxymethyllysine-modified protein or peptide. A composition comprises a humanized monoclonal antibody that binds to an advanced glycation end-product-modified protein or peptide on a cell and a pharmaceutically acceptable carrier.

An image forming apparatus is provided with a printing device, a sheet conveyance path, a protective cover, a swing member, and a biasing member. The sheet conveyance path includes an upper guide portion and a lower guide portion. The swing member is supported inside a main body and can swing upward from a standard position. The biasing member biases the swing member to the standard position. The swing member includes the upper guide portion. The protective cover includes the lower guide portion and a contact portion. The contact portion pushes the swing member upward when the protective cover pivots in an outward position from a closed position. The protective cover can pivot from the closed position to an open position as the contact portion pushes the swing member upward.

An image forming apparatus includes a transfer unit, a fixing unit, a reverse rotary member pair, a first conveyance path, a second conveyance path, an opening and closing member, a first guide member, a second guide member, and a dividing member. The second guide member is supported by the opening and closing member. The second guide member forms an inserted portion where the case of the fixing unit is inserted and another side of guide surfaces of the second conveyance path. The second guide member forms one side of guide surfaces of the first conveyance path in a state where the opening and closing member is in a closed position. The dividing member, in the state where the opening and closing member is in the closed position, divides a gap formed between the second guide member and the case inserted into the inserted portion from the second conveyance path.

An image forming apparatus is provided with a printing device, a sheet conveyance path, a protective cover, a swing member, and a biasing member. The sheet conveyance path includes an upper guide portion and a lower guide portion. The swing member is supported inside a main body and can swing upward from a standard position. The biasing member biases the swing member to the standard position. The swing member includes the upper guide portion. The protective cover includes the lower guide portion and a contact portion. The contact portion pushes the swing member upward when the protective cover pivots in an outward position from a closed position. The protective cover can pivot from the closed position to an open position as the contact portion pushes the swing member upward.