A system for at least partial closed-loop control of a medical condition is disclosed. The system includes at least one medical fluid pump. The medical fluid pump including a sensor for determining the volume of fluid pumped by the pump. Also, at least one continuous analyte monitor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor. The processor includes instructions for delivery of medical fluid based at least on data received from the at least one continuous analyte monitor.

An all-inclusive fluid flow device that can variably magnify differential pressure, measure, and control a flow of a fluid is described. Various procedures, including measuring, controlling, balancing, or calibration procedures can leverage a variably magnified differential pressure measurement. Differential pressure measurements can be measured across the fluid flow device such that a first pressure measurement is taken upstream of the fluid flow device while a second pressure measurement is taken downstream of the fluid flow device. Moreover, one or more of the various pressure measurements, and in particular the downstream pressure measurement, can be performed at stagnation zone where the flow has stagnated. Such can provide significant magnification and/or turndown capabilities and the magnification can vary based on a damper position and/or apertures dimensions.

A mass flow control apparatus and methods for calibrating and tuning the mass flow apparatus are provided. The mass flow apparatus can be calibrated by receiving a calibration input signal that provides one or more properties of a gas that is flowing through a main fluid flow path and performing one or more measurements, using one or more sensors, on the gas. The calibration includes determining a calibration parameter based on the results of the one or more measurements and the calibration input signal and adjusting a proportional valve, based on the calibration parameter, to adjust a flow rate, of the gas through the apparatus, to match a setpoint flow rate.

A method/structure for calibrating a product fluid flow device having one or more apertures with aggregate area A.sub.o, where fluid flows along a fluid flow path therethrough in response to pressure differentials ΔP across the apertures. Calibration is effected relative to a calibration fluid flow device having a geometry and operational parameters corresponding to those of the product fluid flow device. A piecewise curved calibration controller establishes calibration conditions and generates a discrete point calibration flow rate (dpCFR) Function by measuring at a sparse set of points in a range of interest and determining a piecewise curved mathematical representation of fluid flow through the calibration fluid flow device. Data representative of the CFR function is transferred to a product blade controller, which processes the mathematical representation, and controls fluid flow through product fluid flow device based on values extracted from the received dpCFR Function.

A fill adapter system for an infusion pump assembly. The system includes a reusable fill adapter base, the base including a volume control mechanism to adjust an available fill volume of a reservoir of the infusion pump assembly and a pump mechanism configured to pump air into a fluid vial. The system also includes a vial adapter assembly including a first needle configured to penetrate a septum of the fluid vial for fluidly coupling the pump mechanism to the fluid vial and a second needle having a first end configured to penetrate the septum of the fluid vial and a second end configured to penetrate a septum of the reservoir of the infusion pump assembly to allow transfer of fluid from the fluid vial to the reservoir of the infusion pump assembly in response to air being pumped into the fluid vial and a needle carriage adapted to carry the first needle and the second needle, wherein the needle carriage slidably attached to the interior of the vial adapter assembly, wherein the needle carriage adapted to slide from a vial end of the vial adapter to a receptacle end of the vial adapter.

A flow rate control device 100 includes a flow rate control valve 8 having a valve element 8a and a piezoelectric element 8b for moving the valve element, and a control circuit 9 for controlling an operation of the flow rate control valve 8, wherein, in order to perform a pulsed fluid supply, the control circuit 9 is configured so as to open-loop control an applied voltage to the piezoelectric element so that it approaches the target voltage after once applying a voltage V1 exceeding a target voltage V0 corresponding to a target displacement of the piezoelectric element, when a pulsed flow rate setting signal is given.

A fluid flow device that can measure and control a flow of a fluid is described. Various procedures, including measuring, controlling, balancing, or calibration procedures can leverage differential pressure measurement. These differential pressure measurements can be measured across the fluid flow device such that a first pressure measurement is taken upstream of the fluid flow device while a second pressure measurement is taken downstream of the fluid flow device. Moreover, one or more of the various pressure measurements, and in particular the downstream pressure measurement, can be performed at stagnation zone where the flow has stagnated. Such can provide significant amplification and/or turndown capabilities.

An annulus pressure release system includes a gas metering valve assembly having a fluid pathway. The gas metering valve assembly includes a pressure sensor configured to be fluidly coupled to an annulus and to output a sensor signal indicative of a fluid pressure within the annulus. The gas metering valve assembly also includes an electronically actuated adjustable control valve disposed along the fluid pathway and a electronically actuated two-position valve disposed along the fluid pathway. Furthermore, the gas metering valve assembly includes a flow controller. The flow controller, in response to determining the fluid pressure exceeds a threshold pressure, is configured to output a first control signal to the electronically actuated two-position valve indicative of instructions to open the electronically actuated two-position valve, and to output a second control signal to the electronically actuated adjustable control valve indicative of instructions to adjust a flow of fluid through the fluid pathway.

A method of dispensing a therapeutic fluid from a line includes providing an inlet line connectable to an upstream fluid source. The inlet line is in downstream fluid communication with a pumping chamber. The pumping chamber has a pump outlet. The method also includes actuating a force application assembly so as to restrict retrograde flow of fluid through the inlet while pressurizing the pumping chamber to urge flow through the pump outlet. A corresponding system employs the method.

To make it possible to incorporate a fluid resistance element into a flow path through which a fluid flows without difficulty while enjoying advantages from forming a resistance flow path using ceramic, provided is a fluid resistance element including: a ceramic flow path forming member having one or a plurality of resistance flow paths; and a metal covering member covering an outer peripheral face of the flow path forming member.