The present disclosure is related to systems and methods for orthosis design. The method includes obtaining a three-dimensional (3D) model associated with a subject. The method includes obtaining one or more reference images associated with the subject. The method includes determining, based on the 3D model and the one or more reference images, orthosis design data for the subject. The orthosis design data may be used to determine an orthosis for the subject.

The present disclosure describes a computer-implemented method for processing clinical three-dimensional image. The method includes training a fully supervised segmentation model using a labelled image dataset containing images for a disease at a predefined set of contrast phases or modalities, allow the segmentation model to segment images at the predefined set of contrast phases or modalities; finetuning the fully supervised segmentation model through co-heterogenous training and adversarial domain adaptation (ADA) using an unlabelled image dataset containing clinical multi-phase or multi-modality image data, to allow the segmentation model to segment images at contrast phases or modalities other than the predefined set of contrast phases or modalities; and further finetuning the fully supervised segmentation model using domain-specific pseudo labelling to identify pathological regions missed by the segmentation model.

Systems and methods for detecting complex networks in MRI image data in accordance with embodiments of the invention are illustrated. One embodiment includes an image processing system, including a processor, a display device connected to the processor, an image capture device connected to the processor, and a memory connected to the processor, the memory containing an image processing application, wherein the image processing application directs the processor to obtain a time-series sequence of image data from the image capture device, identify complex networks within the time-series sequence of image data, and provide the identified complex networks using the display device.

An X-ray imaging system using multiple puked X-ray sources to perform highly efficient and ultrafast 3D radiography is presented. There are multiple puked X-ray sources mounted on a structure in motion to form an array of sources. The multiple X-ray sources move simultaneously relative to an object on a pre-defined arc track at a constant speed as a group. Electron beam inside each individual X-ray tube is deflected by magnetic or electrical field to move focal spot a small distance. When focal spot of an X-ray tube beam has a speed that is equal to group speed but with opposite moving direction, the X-ray source and X-ray flat panel detector are activated through an external exposure control unit so that source tube stay momentarily standstill equivalently. 3D scan can cover much wider sweep angle in much shorter time and image analysis can also be done in real-time.

Some methods of analyzing one or more brain lesions of a patient comprise, for each of the lesion(s), calculating one or more lesion characteristics from a first 3-dimensional (3D) representation of the lesion obtained from data taken at a first time and a second 3D representation of the lesion obtained from data taken at a second time that is after the first time. The characteristic(s) can include a change, form the first time to the second time, in the lesion's volume and/or surface area, the lesion's displacement from the first time to the second time, and/or the lesion's theoretical radius ratio at each of the first and second times. Some methods comprise characterizing whether the patient has multiple sclerosis and/or the progression of multiple sclerosis in the patient based at least in part on the calculation of the lesion characteristic(s) of each of the lesion(s).

Systems and methods for performing motion artifact correction in medical images. One method includes receiving, with an electronic processor, a medical image associated with a patient, the medical image including at least one motion artifact. The method also includes applying, with the electronic processor, a model developed using machine learning to the medical image for correcting motion artifacts, the model including at least one of a spatial transformer network and an attention mechanism network. The method also includes generating, with the electronic processor, a new version of the medical image, where the new version of the medical image at least partially corrects the at least one motion artifact.

A computer-implemented segmentation method for segmenting a core and a penumbra in a four-dimensional computed tomography perfusion dataset of ischemic tissue in an image region of a patient, includes determining at least one parameter map for at least one perfusion parameter from the computed tomography perfusion dataset; and using the at least one parameter map and the computed tomograph perfusion dataset as input data to a trained function to determine output data, the output data including segmentation information of the penumbra and the core.

DCE MR images are obtained from a MR scanner and under a free-breathing protocol is provided. A neural network assigns a perfusion metric to DCE MR images. The neural network includes an input layer configured to receive at least one DCE MR image representative of a first contrast enhancement state and of a first respiratory motion state and at least one further DCE MR image representative of a second contrast enhancement state and of a second respiratory motion state. The neural network further includes an output layer configured to output at least one perfusion metric based on the at least one DCE MR image and the at least one further DCE MR image. The neural network with interconnections between the input layer and the output layer is trained by a plurality of datasets, each of the datasets having an instance of the at least one DCE MR image and of the at least one further DCE MR image for the input layer and the at least one perfusion metric for the output layer.

The disclosure discloses a method, a device, a system and a computer storage medium for obtaining the CT perfusion imaging parameter maps of brain. The method includes: obtaining CT perfusion images, pre-processing the CT perfusion images, and obtaining discrete contrast agent concentration curves C(n) of each pixel point in the brain tissue; reading the acquisition time information of the CT perfusion images to obtain the acquisition time arrays T(n); intercepting the acquisition time arrays T(n) to obtain the relative acquisition time arrays t(n); combining the discrete contrast agent concentration curves C(n) with the corresponding relative acquisition time arrays t(n) to obtain the discrete time-concentration curves C(t.sub.n) of each pixel point in the brain tissue; after fitting or interpolating the discrete time-concentration curves C(t.sub.n), re-discretizing at the same time interval, and obtaining the discrete time-concentration curves C(n)′ of each pixel point in brain tissue.

Systems and techniques may be used to estimate a real-time patient state during a radiotherapy treatment using a magnetic resonance linear accelerator (MR-Linac). For example, a method may include generating a dictionary of expanded potential patient measurements and corresponding potential patient states using a preliminary motion model. The method may include training, using a machine learning technique, a correspondence motion model relating an input patient measurement to an output patient state using the dictionary. The method may include estimating, using a processor, the patient state corresponding to a 2D MR image using the correspondence motion model. The method may include directing radiation therapy, using the MR-Linac, to a target according to the patient state.