A computer aided diagnostic system and automated method to classify a kidney utilizes medical image data and clinical biomarkers in evaluation of kidney function pre- and post-transplantation. The system receives image data from a medical scan that includes image data of a kidney, then segments kidney image data from other image data of the medical scan. The kidney is then classified by analyzing at least one feature determined from the kidney image data and the at least one clinical biomarker.

An image acquisition unit acquires a phase contrast image consisting of a plurality of phases for each of three spatial directions, in which a pixel value of each pixel represents a velocity of fluid for each of the three directions, the phase contrast image being acquired by imaging a subject including a structure inside which fluid flows by a three-dimensional cine phase contrast magnetic resonance method. An identification unit identifies a region of the structure in the phase contrast image on the basis of a maximum value of the velocity of the fluid between corresponding pixels in each of the phases of the phase contrast image.

The Parkinson's disease information providing apparatus using a neuromelanin image according to an aspect of the present disclosure includes an image receiving unit which acquires an MRI image obtained by capturing a brain of a patient; an image preprocessing unit which preprocesses the acquired MRI image to observe the neuromelanin region used as an image bio marker of the Parkinson's disease; an image processing unit which analyzes the preprocessed MRI image to classify a first image including the neuromelanin region and detects the neuromelanin region from the classified first image; and an image analyzing unit which diagnoses whether the patient has the Parkinson's disease by analyzing whether the detected the neuromelanin region is normal.

A deep learning model learning device is proposed, including: a parametric MRI image input part inputting an image corresponding to a diagnosis region, inputting at least one parametric MRI image constructed on the basis of parameters different from each other, and constructing and providing an MRI moving image by using the at least one parametric MRI image; a cancer detection model learning part receiving an input of the at least one parametric MRI image and the MRI moving image corresponding to the diagnosis region, and learning a deep learning model on the basis of information labeling the cancer region; a labeling reference information providing part providing at least one reference information contributing to the labeling of the cancer region; and a labeling processing part checking the cancer region input on the basis of the at least one reference information and processing the labeling of the checked cancer region.

An exemplary system, method, and computer-accessible medium for detection of structural disorder(s) of patient(s) can be provided which can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), generating gadolinium (“Gd”) enhanced map(s) based on the MRI information using a machine learning procedure(s), and detecting the structural disorder(s) of the patient(s) based on a GD contrast of the Gd enhanced map(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map. The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), or (ii) a Gd-free MRI scan(s). The Gd contrast can be generated in the Gd enhanced map(s) using a T2-weighted MRI image of the portion(s). Structural disorder(s) can include Stroke, tumor, trauma, infection, Multiple sclerosis and/or other inflammatory disease.

Systems and methods for generating a synthesized contrast enhanced medical image are provided. An input medical image is received. A synthesized contrast enhanced medical image is generated based on the input medical image using a trained machine learning based generator network. The synthesized contrast enhanced medical image includes one or more synthesized contrast enhanced regions of pathological tissue. The synthesized contrast enhanced medical image is output.

A method of establishing an enhanced three-dimensional (3D) model of intracranial angiography is provided and includes: obtaining a bright-blood image group, a black-blood image group and an enhanced black-blood image group; preprocessing image pairs to obtain first bright-blood images and black-blood images; registering the first bright-blood image by taking the first black-blood image as reference to obtain a registered bright-blood image group; eliminating flowing void artifact to obtain an artifact-elimination enhanced black-blood image group; subtracting each image of the artifact-elimination enhanced black-blood image group from corresponding black-blood image to obtain angiography enhanced images; establishing a blood 3D model and a vascular 3D model with blood boundary expansion by using the registered bright-blood image group; establishing an angiography enhanced 3D model by using the angiography enhanced images; obtaining an enhanced 3D model of intracranial angiography based on the blood 3D model, the vascular 3D model and the angiography enhanced 3D model.

Systems and methods for analyzing perfusion-weighted medical imaging using deep neural networks are provided. In some aspects, a method includes receiving perfusion-weighted imaging data acquired from a subject using a magnetic resonance (“MR”) imaging system and modeling at least one voxel associated with the perfusion-weighted imaging data using a four-dimensional (“4D”) convolutional neural network. The method also includes extracting spatio-temporal features for each modeled voxel and estimating at least one perfusion parameter for each modeled voxel based on the extracted spatio-temporal features. The method further includes generating a report using the at least one perfusion parameter indicating perfusion in the subject.

A deep learning model learning device is proposed, including: a parametric MRI image input part inputting an image corresponding to a diagnosis region, inputting at least one parametric MRI image constructed on the basis of parameters different from each other, and constructing and providing an MRI moving image by using the at least one parametric MRI image; a cancer detection model learning part receiving an input of the at least one parametric MRI image and the MRI moving image corresponding to the diagnosis region, and learning a deep learning model on the basis of information labeling the cancer region; a labeling reference information providing part providing at least one reference information contributing to the labeling of the cancer region; and a labeling processing part checking the cancer region input on the basis of the at least one reference information and processing the labeling of the checked cancer region.

The present invention discloses an analysis method for dynamic contrast-enhanced magnetic resonance image. Firstly, the time-series signal of vascular contrast agent concentration, AIF, of biological individual is obtained from DCE-MRI time-series data. Secondly, perform the nonlinear least sum of square fitting by using the full Shutter-Speed model (SSM.sub.full) and the simplified vascular Shutter-Speed model (SSM.sub.vas) on the DCE-MRI time-series signal of each pixel, and the fitting results of DCE-MRI time-series signal are obtained. Thirdly, the corrected Akaike Information Criterion (AIC.sub.C) score is used to comparing the DCE-MRI time-series signal fitting results to select the optimal model. If the optimal model is SSM.sub.full, distribution maps of five physiological parameters. K.sup.trans, p.sub.b p.sub.o, k.sub.bo, and k.sub.io, are produced after fitting; if the optimal model is SSM.sub.vas, distribution maps of three physiological parameters, K.sup.trans, p.sub.b, and k.sub.bo, are produced after fitting. Finally, perform error analysis on the k.sub.io and k.sub.bo, resulting the final distribution maps of k.sub.io and k.sub.bo along with distribution maps of parameters K.sup.trans, p.sub.b, p.sub.o. This method can improve the estimation accuracy of K.sup.trans, p.sub.b, p.sub.o, k.sub.bo and k.sub.io.