A method for producing Pb-212 and Ac-225 isotopes is disclosed. The method comprises irradiating a Ra-226 containing target with charged particles and/or photons for producing at least Ac-225 isotopes and Ac-224 isotopes. The method further comprises after a cooling time, applying chromatography for separating actinium from the remaining fraction containing radium. The method also comprises, after a first further waiting time, applying extraction chromatography using a resin having an 18-crown-6 ether or an equivalent of an 18-crown-6 ether, as extractant in HNO3 and/or HCl for separating Pb from the remaining fraction containing radium.

The embodiments of the present disclosure provide a method for producing Ac-225 from Ra-226, comprising submitting Ra-226 to a photo-nuclear process, collecting an electrochemical precipitation of an Ac-225 on a cathode in a recipient, removing the cathode from the recipient after the electrochemical precipitation of the Ac-225, transferring the cathode to a hot cell environment, and extracting the Ac-225 from the cathode in the hot cell environment. The Ra-226 may comprise a liquid solution in the recipient, and submitting Ra-226 to the photo-nuclear process may comprise irradiating the Ra-226 to produce Ra-225. The Ra-225 may decay into Ac-225 upon irradiation of the Ra-226.

The actinium generator described herein is based on peroxide precipitation of thorium from its daughter products radium and actinium. In this system, the “actinium generator” is a quantity of solid thorium peroxide stored under a cover solution. The thorium peroxide is stored as a suspension to allow for the buildup of the decay products radium and actinium in the suspension. The suspension is then treated with a peroxide solution and the solid and liquid phases are separated. The thorium remains in the solid peroxide form while the soluble actinium and radium are removed with the liquid phase in a rinsing step. After rinsing, an amount of the rinsing solution is retained with the thorium peroxide solid as a fresh cover solution to form another suspension for storage. This new suspension is then stored to allow actinium and radium to again build up in the suspension for a subsequent separation cycle.

In one aspect, the technology relates to a method of producing Ac, the method including preparing a phosphate-modified titania material to produce an ion-exchange material, contacting a solution including .sup.229Th with the ion-exchange material to produce a Th-loaded titania material, eluting the Th-loaded titania material with a wash solution to produce an eluted solution containing eluted compounds including .sup.225Ac, concentrating the eluted solution to generate eluted compounds including the .sup.225Ac, and separating the .sup.225Ac from the eluted compounds.

The disclosure provide an apparatus for producing a nuclide by using a liquid target which can perform the nuclear reaction process and can discharge the radioactive gas such as Radon within the vial. As described above, an apparatus for producing a nuclide by using a liquid target according to the present disclosure can minimize quantitative loss of a reactant by performing the nuclear reaction process using a target of a liquefied state and reusing a liquefied target on which the nuclear reaction process has not been performed, and can improve safety by enabling the radioactive gas generated to be disposed.

One embodiment of the present invention relates to a production method of .sup.225Ac includes; a production step of a .sup.226Ra target including an electrodeposition step of electrodepositing a .sup.226Ra-containing substance on a substrate by using an electrodeposition solution that contains .sup.226Ra ions and a pH buffer, and an irradiating step of irradiating the .sup.226Ra target with at least one selected from charged particles, photons, and neutrons.

A method for producing 225.sup.A including: a method (X) for purifying a .sup.226Ra-containing solution, including an adsorption step of allowing a .sup.226Ra ion to adsorb onto a carrier having a function of selectively adsorbing a divalent cation by bringing a .sup.226Ra-containing solution into contact with the carrier under an alkaline condition, and an elution step of eluting the .sup.226Ra ion from the carrier under an acidic condition; a method for producing a .sup.226Ra target, including an electrodeposition liquid preparation step of preparing an electrodeposition liquid by using a purified .sup.226Ra-containing solution obtained by the method (X), and an electrodeposition step of electrodepositing a .sup.226Ra-containing substance on a substrate by using the electrodeposition liquid; and a step of irradiating a .sup.226Ra target produced by the method for producing a .sup.226Ra target with at least one selected from a charged particle, a photon, and a neutron by using an accelerator.

A method for the manufacture of Actinium-225 from a Radium-226 containing material. Radium-226 containing starting target material is shielded with a thermal neutron absorption shield and is subjected to neutron irradiation from a moderated nuclear reactor. Radium-226 is thereby converted into Radium-225 to provide a Radium-225-containing material. The Radium-225 in the Radium-225 containing material is allowed to decay into Actinium-225, and the Actinium-225 is isolated from the Radium-225 containing material. The neutron absorption shield shields the starting target material from neutrons having an energy in the range of 20 eV to 1000 eV.

An object of the present invention is to provide a method for purifying efficiently and easily a .sup.226Ra-containing solution obtained when .sup.225Ac is produced from a .sup.226Ra target, a method for producing a .sup.226Ra target by using the purified .sup.226Ra-containing solution obtained by the above purification method, and a method for producing .sup.225Ac including these above methods. The method for purifying a .sup.226Ra-containing solution according to the present invention is characterized by including an adsorption step (R1) of allowing .sup.226Ra ions to adsorb onto a carrier having a function of selectively adsorbing divalent cations by bringing a .sup.226Ra-containing solution (a) into contact with the carrier under an alkaline condition; and an elution step (R2) of eluting the .sup.226Ra ions from the carrier under an acidic condition.

One embodiment of the present invention relates to a production method of a .sup.226Ra target, a production method of .sup.225Ac, or an electrodeposition solution for producing a .sup.226Ra target, and the production method of a .sup.226Ra target includes an electrodeposition step of electrodepositing a .sup.226Ra-containing substance on a substrate by using an electrodeposition solution that contains .sup.226Ra ions and a pH buffer.