AQUEOUS SOLUTION FOR A SURGERY AND METHOD FOR USING THE SAME

Abstract

The present invention provides an aqueous solution for a surgery, especially laparoscopic surgery and a method for using such a liquid solution during surgery. The aqueous solution comprises at least an antioxidant agent and a haemostatic agent in order to prevent intestinal obstruction, pain and difficulties in repeated surgeries. The present invention provides also a method for using such an aqueous solution during a surgery.

Claims

1. Aqueous solution for controlling oxidative stress and enhanced visual recognition during a surgery, comprising Methylene Blue and a haemostatic agent.

2. Aqueous solution according to claim 1, comprising one of the following as solvent: a. sterile water b. Normal Saline, or c. an isotonic solution containing about 6.5 g NaCl, 0.42 g KCl, 0.25 g CaCl.sub.2 and 0.2 g of sodium bicarbonate dissolved in one liter of distilled water.

3. Aqueous solution according to claim 1, comprising at least 100 mL, preferably 100 mL to 3 L, more preferably 1 L or 3 L solvent.

4. Aqueous solution according to claim 1, comprising an antioxidant agent in addition to Methylene Blue dye.

5. Aqueous solution according to claim 1, comprising 1 to 3% or about 1% Methylene Blue or per 1000 mL, 1 to 250 mg of Methylene Blue or per 100 mL, 1 to 5 mg Methylene Blue, more preferably 3 mg Methylene Blue.

6. Aqueous solution according to claim 1, comprising an antioxidant agent in addition to Methylene Blue dye in form of one of the Vitamins C, E and A or a combination thereof.

7. Aqueous solution according to claim 1, comprising about 500 mg/3000 cc Vitamin C as an antioxidant agent in addition to Methylene Blue dye.

8. Aqueous solution according to claim 1, wherein said haemostatic agent comprises a local vasoconstructive agent or Vasopressin.

9. Aqueous solution according to claim 1, comprising about 0.01% Vasopressin.

10. Aqueous solution according to claim 1, further comprising a local anesthetic.

11. Aqueous solution according to claim 1, comprising about 1% Lidocain.

12. Method for using an aqueous solution according to claim 1 for controlling oxidative stress and enhanced visual recognition during a surgery, comprising: a. introducing said aqueous solution into a site of surgery to float the tissues in said site of surgery; b. viewing and locating a part of said site under said aqueous solution for excision; and c. excision of said part under said aqueous solution.

13. Method according to claim 12, wherein said site of surgery is a peritoneum, an abdominal cavity or a thoracic site of a patient and said surgery comprises a laparoscopy and/or a laparotomy.

14. Method according to claim 12, further comprising trapping said aqueous solution in the peritoneum to distend the peritoneum.

15. Method according to claim 12, further comprising introducing at least 100 mL, preferably 100 mL to 3 L, more preferably 1 L or 3 L of said aqueous solution into abdominal cavity.

16. Method according to claim 12, further comprising further adding of said aqueous solution onto said site of excision before completing the surgery.

17. Method according to claim 12, further comprising covering said site of excision with said aqueous solution before completing the surgery.

18. Method according to claim 12, further comprising leaving some of said aqueous solution within the abdominal cavity to cover said site of excision.

19. Method according to claim 12, further comprising introducing said aqueous solution is performed by an irrigation pump.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0039] The accompanying drawings, referred to herein and constituting a part hereof, illustrate preferred embodiments of the present invention and together with the description, serve to explain the principles of the present invention, wherein:

[0040] FIG. 1 is a partial cross-sectional side view of a female body comprising an embodiment of the present invention depicting a procedure of a laparoscopic surgery;

[0041] FIG. 2 is a partial cross-sectional side view of a female body comprising an embodiment of the present invention depicting the procedure after the laparoscopic surgery;

[0042] FIG. 3 shows the abdominal cavity of FIG. 1 in a perspective view.

DESCRIPTION OF AN EXEMPLARY EMBODIMENT

[0043] Referring to FIG. 1, a partial female body is illustrated in cross-sectional view showing the peritoneum (15), laparoscopes (10) placed through the abdominal wall and the transvaginal-transdouglas route, the uterus (16), the bladder (12), the rectum (18) and the small intestine (20).

[0044] According to an embodiment of the present invention shown in FIG. 1, about 1 L of an aqueous solution (14) of the present invention has been introduced into the peritoneum (15) comprising 500 mg/3000 cc Vitamin C, 0.01% Vasopressin, 1% Lidocain and 1% Methylene Blue dye. However another composition may be introduced as described throughout this specification. The blue colored solution (14) distends the peritoneum, makes the tissues in the retroperitoneum (15) float and provides contrast in the background of the distended peritoneum (15) and in the retroperitoneum (15) during near contact scanning with the laparoscope (10). Although a laparoscopy has been illustrated by this embodiment, the aqueous solution of the present invention may also be used in a laparotomy. FIG. 3 shows the surgery site of FIG. 1 in a different perspective. The blue colored solution (14) provided here in the retroperitoneum (15) background contrast for recognizing subtle endometriosis around the uterus (16) and the bladder (12).

[0045] The aqueous solution (14) of this embodiment comprises Methylene Blue and Vitamin C as antioxidant agents and Vasopressin as haemostatic agent. The aqueous solution (14) comprises Normal Saline as isotonic solution. The aqueous solution (14) comprises further Lidocain as a local anesthetic.

[0046] According to this embodiment, the inventive method comprises introducing the aqueous solution (14) into peritoneum (15) of a patient during a laparoscopic endometriosis surgery to float the tissues in the peritoneum (15), viewing and locating a tissue having endometriosis for excision under the aqueous solution (14), and excision of the tissue having endometriosis under said aqueous solution (14). According to this embodiment, the aqueous solution (14) has been trapped in the peritoneum (15) to distend the abdominal cavity. 1 L of said aqueous solution was introduced into peritoneum (15). According this embodiment, the method further comprises further addition of the aqueous solution (14) onto the site of excision and covering said site of excision with the aqueous solution (14) before completing the surgery, hence a part of the aqueous solution (14) is left within peritoneum (15) covering the site of excision. According this embodiment the aqueous solution (14) is filled into the abdominal cavity by an irrigation pump.

[0047] Referring to FIG. 2, the partial female body shown in FIG. 1 is illustrated in cross-sectional view showing the peritoneum (15), the uterus (16), the bladder (12), the rectum (18) and the small intestine (20) after the surgery procedure. As shown in FIG. 2, just the site of excision is covered with the inventive aqueous solution (14), since the inventive aqueous solution (14) was removed partially from peritoneum (15) by absorption into the body before completing the surgery and a part of the inventive aqueous solution (14) was left within the abdominal cavity enough to cover the site of excision and the pressure within the abdominal cavity has been reduced and the distension of the peritoneum has been resolved.

[0048] All abnormal peritoneum visually recognized by nearcontact laparoscopic inspection were excised using cold scissors. Retroperitoneum of the pelvic sidewalls were hydrodistended with Methylene Blue containing aqueous solution. Elimination of red, yellow and white hues allow background contrast for visual assistance recognizing nonpigmented foci of peritoneal thickening suggestive of subtle endometriosis. Elimination of high-end spectrum of light using the inventive solution with hydrodistention of the retroperitoneum enhances the surgeon's vision.

[0049] While the above description contains many specifics, these specifics should not be construed as limitations on the scope of the invention, but merely as exemplifications of preferred embodiments thereof. Those skilled in the art will envision many other possible variations that are within the scope and spirit of the invention as defined by the claims appended hereto.