Laser speckle interferometric system and method for mobile devices
10206576 ยท 2019-02-19
Assignee
Inventors
- Alexander Viacheslavovich Shcherbakov (Moscow region, RU)
- Alexey Dmitrievich Lantsov (Moscow region, RU)
Cpc classification
A61B5/02438
HUMAN NECESSITIES
A61B5/0059
HUMAN NECESSITIES
G01B9/02094
PHYSICS
International classification
Abstract
The laser speckle interferometric system includes a memory for storing a measurement result of a correction parameter and models for matching a result of processing the speckle pattern to the parameters of the object and a processor for stabilizing the speckle pattern detected by controlling a condition for detecting the speckle pattern in real time, processing a time-varying function representing a temporal change in the speckle pattern based on the speckle pattern and the parameters and generating data indicating tested parameters.
Claims
1. A laser speckle interferometric system for a mobile device, the laser speckle interferometric system configured to monitor one or more parameters of an object, the system comprising: a laser light source configured to emit a laser beam to the object; a detector configured to receive the laser beam that is emitted to and scattered by the object, and detect at least one speckle pattern from the received laser beam, said speckle pattern being representative of a first biological activity of the object; a memory configured to store a measurement result of a correction parameter and one or more predetermined patterns for matching a result of processing the speckle pattern to the one or more parameters of the object; a processor configured to process the speckle pattern of the first biological activity that is detected from the received laser beam; and a controller configured to control a light intensity distribution and a radius of the speckle pattern in real time so that a ratio of an average light intensity to a maximum light intensity of the speckle pattern is greater than a predetermined value and the radius of the detected speckle pattern is within a predetermined range by adjusting a feedback signal between the laser light source and the detector and an output power of a subsequent laser light source, wherein the processor stabilizes the detected speckle pattern, while the speckle pattern is being measured, by monitoring a center of the speckle pattern, determines a time-varying function for processing the stabilized speckle pattern and representing a temporal change in the speckle pattern of the first biological activity according to a change in the one or more parameters of the object to ascertain a second biological activity of the object in which vibrational components of the object are removed, generates data representing the one or more parameters corresponding to the second biological activity of the object, and displays the data representing the one or more parameters in numerical form to a user.
2. The laser speckle interferometric system of claim 1, wherein the predetermined value is 0.15.
3. The laser speckle interferometric system of claim 1, wherein the predetermined range is from R.sub.0/3 to R.sub.0, and R.sub.0 is 80% of an entire detected light intensity.
4. The laser speckle interferometric system of claim 3, wherein the size of the detected speckle pattern is controlled by monitoring the center (x.sub.c, y.sub.c) of the detected speckle pattern, wherein x.sub.c and y.sub.c are coordinates of the center of the detected speckle pattern and are calculated using
5. The laser speckle interferometric system of claim 1, further comprising an outputter configured to perform at least one of a function of outputting the data generated by the processor to a display and a function of transmitting the data to another device.
6. The laser speckle interferometric system of claim 5, wherein the outputter is further configured to output the data to a display of the mobile device.
7. The laser speckle interferometric system of claim 5, wherein the outputter is further configured to output the data to a sound device of the mobile device.
8. The laser speckle interferometric system of claim 1, wherein the time-varying function represents a temporal change in the speckle pattern in a form of a sequence of values of correlation coefficients between respective light intensity distributions of two neighboring speckle patterns.
9. The laser speckle interferometric system of claim 1, wherein the time-varying function represents a temporal change in the speckle pattern in a form of a sequence of values of correlation coefficients between a reference light intensity distribution and a light intensity distribution of the speckle pattern.
10. The laser speckle interferometric system of claim 1, wherein the time-varying function represents a temporal change in the speckle pattern in a form of a sequence of a sum of Fourier Series in each speckle pattern.
11. The laser speckle interferometric system of claim 1, wherein the time-varying function represents a temporal change in the speckle pattern in a form of a sequence of values of a wavelet transform applied to each speckle pattern.
12. The laser speckle interferometric system of claim 1, wherein the mobile device comprises at least one of a mobile phone and a smart phone.
13. The laser speckle interferometric system of claim 1, wherein the mobile device comprises at least one of a tablet computer, a personal digital assistant (PDA), and a laptop.
14. The laser speckle interferometric system of claim 1, wherein the mobile device comprises a watch.
15. The laser speckle interferometric system of claim 1, wherein the mobile device comprises a display that is configured to be placed on a head of the user.
16. The laser speckle interferometric system of claim 1, wherein the mobile device comprises a portable media player.
17. The laser speckle interferometric system of claim 1, wherein the laser light source and the detector are disposed in a housing of the mobile device.
18. The laser speckle interferometric system of claim 1, wherein the detector is disposed in a main body of the mobile device, and the laser light source is disposed in a detachable housing connected to the mobile device.
19. A method of monitoring one or more parameters of an object by using a laser speckle interferometric system for a mobile device, the method comprising: emitting a laser beam to the object; receiving the laser beam that is emitted to and scattered by the object; detecting a speckle pattern as an image from the received laser beam, said speckle pattern being representative of a first biological activity of the object; processing the speckle pattern of the first biological activity that is detected from the received laser beam; and controlling a light intensity distribution and a radius of the speckle pattern in real time so that a ratio of an average light intensity to a maximum light intensity of the speckle pattern is greater than a predetermined value and the radius of the detected speckle pattern is within a predetermined range by adjusting a feedback signal between the laser light source and a detector and an output power of a subsequent laser light source, wherein the processing of the speckle pattern comprises: stabilizing, while the speckle pattern is being measured, the speckle pattern by monitoring a center of the speckle pattern and controlling a radius of the speckle pattern; determining a time-varying function used to process the stabilized speckle pattern and representing a temporal change in the speckle pattern of the first biological activity according to a change in the one or more parameters of the object to ascertain a second biological activity of the object in which vibrational components of the object are removed; generating data representing the one or more parameters corresponding to the second biological activity of the object; and displaying the data representing the one or more parameters in numerical form to a user.
20. The method of claim 19, wherein the predetermined value is 0.15.
21. The method of claim 19, wherein, the predetermined range is from R.sub.0/3 to R.sub.0, and R.sub.0 is 80% of an entire detected light intensity.
22. The method of claim 21, wherein a size of the detected speckle pattern is controlled by monitoring the center of the detected speckle pattern, wherein x.sub.c and y.sub.c are coordinates of the center of the detected speckle pattern and are calculated using
23. The method of claim 19, further comprising at least one of outputting, to a display, data received in a form of the processed speckle pattern and transmitting the data to another device.
24. The method of claim 19, wherein, in the detecting of the speckle pattern, the detected speckle pattern is stored as a data file.
25. The method of claim 19, wherein the stabilizing of the speckle pattern comprises: receiving data from the mobile device; and excluding a speckle pattern from the processing, wherein the excluded speckle pattern is obtained at a location where the mobile device is not optimized with regard to the object.
26. The method of claim 19, wherein the time-varying function represents a temporal change in the speckle pattern in a form of a sequence of values of correlation coefficients between respective light intensity distributions of two neighboring speckle patterns.
27. The method of claim 19, wherein the time-varying function represents a temporal change in the speckle pattern in a form of a sequence of values of correlation coefficients between a reference light intensity distribution and a current light intensity distribution of the speckle pattern.
28. The method of claim 19, wherein the time-varying function represents a temporal change in the speckle pattern in a form of a sequence of a sum of Fourier Series in each speckle pattern.
29. The method of claim 19, wherein the time-varying function represents a temporal change in the speckle pattern in a form of a sequence of values of a wavelet transform applied to each speckle pattern.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) These and/or other aspects will become apparent and more readily appreciated from the following description of one or more exemplary embodiments, taken in conjunction with the accompanying drawings in which:
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DETAILED DESCRIPTION
(14) Reference will now be made to exemplary embodiments, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to like elements throughout. The exemplary embodiments may, however, be embodied in many different forms and should not be construed as being limited to one or more exemplary embodiments set forth herein. Like reference numerals in the drawings denote like elements, and sizes of components in the drawings may be exaggerated for convenience of explanation. Expressions such as at least one of, when preceding a list of elements, modify the entire list of elements and do not modify the individual elements of the list.
(15) A laser speckle interferometric system may include an information input unit (e.g., inputter) including a laser light source and a detector; a memory unit (e.g., memory) storing research model data, correction data, and a measurement result; and a processing unit (e.g., processor) for performing speckle stabilization and speckle processing. Also, the laser speckle interferometric system may further include an output unit (e.g., outputter) for displaying the measurement result to a user and/or transmitting received data to another device. A blood pressure and pulse rate of a person may be obtained according to a laser speckle interferometric method.
(16) A laser beam emitted from the laser light source is scattered on a skin surface of a wrist of a person, and a speckle pattern formed by scattering of coherent light is detected by the detector and then recorded. Pulsation in arteries causes a skin movement that affects the detected speckle pattern. To detect pulsation having a signal to noise ratio that is high enough to perform accurate measurement, the influence of a vibration caused by a displacement between the mobile device and an object under examination may be removed. The detection of pulsation may be achieved by monitoring, in real time, parameters used to detect optimal conditions [Kulchin Yu. N., Vitrik O. B., Lantsov A. D., Correlation Method for Processing Speckles of Signals from Single-Fiber Multimode Interferometers by using Charge-Coupled Devices, Quantum Electron, (2006), 36(4), 339-342]. The parameters may be a statistical parameter of a light intensity distribution in the detected speckle pattern satisfying I.sub.av/I.sub.max>0.15 (where, I.sub.max is a maximum value of a detected light intensity, and I.sub.av is a mean value of the detected light intensity) and a radius of a detected speckle within a range of R0/3<R<R0 (where, R0 is a radius of the detected speckle that corresponds to 80% of the entire detected light intensity). The light intensity distribution is controlled by adjusting a feedback signal between the light source and the detector and an output of a subsequent light source. An optimal (i.e., acceptable) size of the detected speckle pattern may be controlled by monitoring a center (x.sub.c, y.sub.c) of the detected speckle pattern, wherein x.sub.c and y.sub.c are the coordinates of the center of the speckle pattern and are calculated according to Equations 1 and 2 below.
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(18) wherein, x and y are coordinates on a detection surface of the detector, n is a total number of pixels in the detection surface of the detector, and I is a value of a light intensity.
(19) A stabilized speckle pattern may be used to determine a time-varying function that is displayed as a sum of all components obtained from Fourier Series applied to respective images of the detected speckle pattern. The time-varying function represents a temporal change in the speckle pattern and may include information regarding the parameters of an object.
(20) The determined time-varying function corresponds to time dependence of the blood pressure at an artery wall, and a repetition frequency of a maximum value of the time-varying function corresponds to the heart beats of a person. A shape of the time-varying function, that is, an envelope, may be determined based on a temporal shape of the blood pressure, among other physiological parameters. The number of detected peaks of the time-varying function may be counted to determine a size of a pulsation for a predetermined time, for example, 1 minute. Before the laser speckle interferometric system and method for the mobile device is used, the entire system may be corrected, that is, the entire system may be calibrated by recording several periods of a pulse wave and to store the recorded periods of the pulse wave in the memory unit to thereby determine a value of the blood pressure. Almost immediately before or after the above procedure, the blood pressure may be measured via an existing sphygmomanometer and then an obtained result may be recorded in the memory unit. Therefore, the memory unit may store a shape of the pulse wave and the blood pressure values corresponding thereto. After a correction process, there is no need to use the existing sphygmomanometer, and the blood pressure may be measured any time via the laser speckle interferometric system and method.
(21) Current values of the blood pressure may be calculated as follows. The processing unit calculates proportional coefficients to determine a difference between a current shape of a blood wave and the pulse wave stored in the memory unit. Then, the calculated proportional coefficients and a corrected value of the blood pressure are multiplied. A result value of the blood pressure is displayed to a user and may be selectively transmitted to another device in a wireless manner.
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(23) The laser light source 1 emits a laser beam having coherence. The laser light source 1 may be, for example, a semiconductor laser diode. The detector 2 may capture a speckle pattern image and may be, for example, an image sensor or a camera including an image sensor. The processing unit 14 and the memory unit 15 may be integrated into a main body 3 of the mobile device such that vibrations generated by the displacement between the laser light source 1 and the detector 2 are dampened.
(24) Also, the laser speckle interferometric system may further include a display for displaying a pulse rate or blood pressure (refer to
(25) The mobile device may be, for example, a mobile phone or a smart phone, a tablet computer, a personal digital assistant (PDA), a laptop, a portable media player, a watch, or a display placed on a user's head.
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(28) In operation S10, the control of laser light source 1 and the detector 2 is initialized. After initialization, the laser light source 1 of the laser speckle interferometric system emits a laser beam onto a region of interest (ROI) of the object. The laser beam is scattered in the region of interest and is detected by the detector.
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(30) After an initial setting is completed, stabilization and measurement of the speckle pattern are simultaneously performed. An image of light emitted from the laser light source 1 and scattered on a subject under examination is captured in operation S13. Then, a central position of the speckle pattern is predicted based on the captured image in operation S14. Also, an optimal processing area is predicted and then selected in operation S15. The stabilization of the speckle pattern may be achieved by monitoring the optimal conditions for detecting the speckle pattern and the central point of the speckle pattern at the same time. The coordinates of the center of the speckle pattern, that is, x.sub.c and y.sub.c, are calculated based on the above Equation 1.
(31) The processing unit 14 performs image processing in real time and may determine not to store each frame in the memory unit 15. This may improve the performance of the entire system. The processing unit 14 performs a Fourier transform on each frame and determines a set of spatial frequencies from the image in operation S16. The transformed frames of the image are characterized by a set of spatial frequencies, and a sum of all components corresponds to the time-varying function at a predetermined point in time. The time-varying function represents a temporal change in the speckle pattern in the form of a sequence of a sum of Fourier Series. However, the time-varying function is not limited thereto and may represent a temporal change in the speckle pattern in the form of a sequence of values of correlation coefficients between a reference intensity distribution and the light intensity distribution at the speckle pattern or in the form of a sequence of values of wavelet transform coefficients applied to each speckle pattern.
(32) Then, noise is removed by filtering in operation S19.
(33) Obtained values are stored in the memory unit 15 in operation S17. In operation S18, if the speckle pattern is not sufficiently detected, the above operations are repeated starting from operation S13.
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(35) In operation S20, one or more models are used to describe a relationship between a single pulse wave and the blood pressure corresponding thereto. The single pulse wave is obtained during one cardiac cycle and is stored in the memory unit 15.
(36) An obtained value of the blood pressure may be displayed on a display of the mobile device in operation S21. The obtained value of the blood pressure may be stored in the memory unit 15 of the mobile device and may be transmitted to another device in a wireless manner or another manner well known to one of ordinary skill in the art.
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(42) The laser speckle interferometric system and method according to one or more exemplary embodiments may be applied to a mobile device used to monitor biological parameters of a human or an animal. It may be understood by one of ordinary skill in the art that the laser speckle interferometric system and method may be used in security and medical system fields. The laser speckle interferometric system and method according to the one or more exemplary embodiments may have high mobility and portability because one or more parameters of a human may be tracked without using a specially designed device.
(43) The laser speckle interferometric system and method according to one or more exemplary embodiments may be embodied by hardware, software, firm ware, an integrated circuit, a microprocessor, a memory device, a computer-readable recording medium, and any combination thereof.
(44) A method of monitoring one or more parameters of an object by using the laser speckle interferometric system for a mobile device may be written as a program executable by a computer and may be implemented in a general-use digital computer using a non-transitory computer-readable recording medium. The non-transitory computer-readable recording medium includes magnetic storage media (e.g., ROM, RAM, USBs, floppy disks, hard disks, etc.), optical recording media (e.g., CD-ROMs, or DVDs), and PC interfaces (e.g., PCI, PCI-express, Wi-fi, etc.), etc.
(45) It should be understood that exemplary embodiments described herein should be considered in a descriptive sense only and not for purposes of limitation. Descriptions of features or aspects within an exemplary embodiment should be considered as available for other similar features or aspects in other exemplary embodiments.
(46) While one or more exemplary embodiments have been described with reference to the figures, it should be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope as defined by the following claims.