Drug Delivery Silicone Composition to improve Active ingredient Elution. The invention relates to a new curable liquid silicone rubber composition which after curing provides a silicone elastomer useful as a drug delivery device comprising an active pharmaceutical ingredient (API) having terminal alkene, alkyne or carbonyl functionalities exhibiting an increased recovery of the active pharmaceutical ingredient.

Drug Delivery Silicone Composition to improve Active ingredient Elution. The invention relates to a new curable liquid silicone rubber composition which after curing provides a silicone elastomer useful as a drug delivery device comprising an active pharmaceutical ingredient (API) having terminal alkene, alkyne or carbonyl functionalities exhibiting an increased recovery of the active pharmaceutical ingredient.

Polymer compositions for making a stabilized polymeric articles that are resistant to discoloration upon exposure to UV-C light having: (i) an organic polymeric material; and (ii) a hindered phenol, organic phosphite, or a combination thereof, with the provisos that: (a) the OH group on the aromatic ring of the hindered phenol is flanked by two tertiary hydrocarbyl groups, and (b) the organic phosphite does not have any —OAr group linked directly to the P atom of the phosphite, wherein Ar represents an unsubstituted or substituted aryl group, are provided herein. Reduced discoloration is associated with the use of specific hindered phenols and the organic phosphites compared to other hindered phenols and organic phosphites, even in the absence of other polymer additives including UV absorbers, hindered amine light stabilizers (HALS), metal oxides and/or barium salts. Methods of reducing discoloration of an organic polymeric material upon exposure to UV-C light are also provided, wherein such methods include the step of adding to the organic polymeric material a stabilizing amount of hindered phenol, organic phosphite, or a combination thereof.

Polymer compositions for making a stabilized polymeric articles that are resistant to discoloration upon exposure to UV-C light having: (i) an organic polymeric material; and (ii) a hindered phenol, organic phosphite, or a combination thereof, with the provisos that: (a) the OH group on the aromatic ring of the hindered phenol is flanked by two tertiary hydrocarbyl groups, and (b) the organic phosphite does not have any —OAr group linked directly to the P atom of the phosphite, wherein Ar represents an unsubstituted or substituted aryl group, are provided herein. Reduced discoloration is associated with the use of specific hindered phenols and the organic phosphites compared to other hindered phenols and organic phosphites, even in the absence of other polymer additives including UV absorbers, hindered amine light stabilizers (HALS), metal oxides and/or barium salts. Methods of reducing discoloration of an organic polymeric material upon exposure to UV-C light are also provided, wherein such methods include the step of adding to the organic polymeric material a stabilizing amount of hindered phenol, organic phosphite, or a combination thereof.

Polymer compositions for making stabilized polymeric articles that are resistant to at least one deleterious effect of discoloration, cracking, or crazing upon exposure to UV-C (190-280 nm) light are provided herein, wherein the polymer compositions include: (i) an organic polymeric material; and (ii) a stabilizer composition comprising: an antioxidant selected from the group consisting of hindered phenols, phosphites and phosphonites, and mixtures thereof; and a light stabilizer selected from the group consisting of hindered amine light stabilizers (HALS), UV absorbers (UVA), hindered benzoates, and mixtures thereof, even where barium compounds (such as barium salts) are absent from the stabilizer composition, and with the proviso that the HALS is not bis(2,2,6,6,-tetramethyl-4-piperidyl) sebacate (TINUVIN™ 770) alone. At least one of reduced discoloration, cracking, or crazing upon exposure to UV-C light is associated with the use of the light stabilizer in combination with the antioxidant compared to the antioxidant in the absence of the light stabilizer. Methods of stabilizing organic polymeric materials against the deleterious effects of UV-C light by adding to the organic polymeric materials the antioxidant and the light stabilizer, are also provided.

Polymer compositions for making stabilized polymeric articles that are resistant to at least one deleterious effect of discoloration, cracking, or crazing upon exposure to UV-C (190-280 nm) light are provided herein, wherein the polymer compositions include: (i) an organic polymeric material; and (ii) a stabilizer composition comprising: an antioxidant selected from the group consisting of hindered phenols, phosphites and phosphonites, and mixtures thereof; and a light stabilizer selected from the group consisting of hindered amine light stabilizers (HALS), UV absorbers (UVA), hindered benzoates, and mixtures thereof, even where barium compounds (such as barium salts) are absent from the stabilizer composition, and with the proviso that the HALS is not bis(2,2,6,6,-tetramethyl-4-piperidyl) sebacate (TINUVIN™ 770) alone. At least one of reduced discoloration, cracking, or crazing upon exposure to UV-C light is associated with the use of the light stabilizer in combination with the antioxidant compared to the antioxidant in the absence of the light stabilizer. Methods of stabilizing organic polymeric materials against the deleterious effects of UV-C light by adding to the organic polymeric materials the antioxidant and the light stabilizer, are also provided.

A composition includes specific amounts of a poly (phenylene ether), a hydrogenated block copolymer of an alkenyl aromatic monomer and a conjugated diene, a polypropylene, a polybutene, a flame retardant, and an ultraviolet absorbing agent comprising a bis(benzotriazole) compound. The composition is particularly useful for forming the jacket layer of electrical and optical cables.

A composition includes specific amounts of a poly (phenylene ether), a hydrogenated block copolymer of an alkenyl aromatic monomer and a conjugated diene, a polypropylene, a polybutene, a flame retardant, and an ultraviolet absorbing agent comprising a bis(benzotriazole) compound. The composition is particularly useful for forming the jacket layer of electrical and optical cables.

Provided is an ultraviolet absorber with a high molar extinction coefficient that is particularly superior in heat resistance, odor suppression at the time of thermal decomposition and long-wavelength absorption, as compared to a conventional ultraviolet absorber. The ultraviolet absorber is an ultraviolet absorber comprising a 2-phenylbenzotriazole derivative having a bonding group represented by the following formula (I) or (II):

##STR00001## wherein X represents a nitrogen atom, an oxygen atom or a residue obtained by eliminating a hydrogen atom from an amide group; l represents an integer of 0 or 1; Y.sup.1 represents a substituted or unsubstituted aromatic hydrocarbon group; m is 1 when X is a nitrogen atom or a residue obtained by eliminating a hydrogen atom from an amide group, or 0 when X is an oxygen atom; Y.sup.2 represents a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group, or a substituted or unsubstituted aromatic hydrocarbon group,

##STR00002## wherein Y.sup.3 forms a substituted or unsubstituted hetero ring together with a nitrogen atom N.

Provided is an ultraviolet absorber with a high molar extinction coefficient that is particularly superior in heat resistance, odor suppression at the time of thermal decomposition and long-wavelength absorption, as compared to a conventional ultraviolet absorber. The ultraviolet absorber is an ultraviolet absorber comprising a 2-phenylbenzotriazole derivative having a bonding group represented by the following formula (I) or (II):

##STR00001## wherein X represents a nitrogen atom, an oxygen atom or a residue obtained by eliminating a hydrogen atom from an amide group; l represents an integer of 0 or 1; Y.sup.1 represents a substituted or unsubstituted aromatic hydrocarbon group; m is 1 when X is a nitrogen atom or a residue obtained by eliminating a hydrogen atom from an amide group, or 0 when X is an oxygen atom; Y.sup.2 represents a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group, or a substituted or unsubstituted aromatic hydrocarbon group,

##STR00002## wherein Y.sup.3 forms a substituted or unsubstituted hetero ring together with a nitrogen atom N.