Analyte sensors and methods for fabricating analyte sensors in a roll-to-roll process are provided. In an exemplary embodiment, a method includes providing a roll of a polyester substrate having a first side coated with a layer of platinum, wherein the platinum is in direct contact with the polyester substrate; patterning the layer of platinum to form electrodes; punching the polyester substrate to form ribbons, wherein each ribbon is connected to a remaining polyester substrate web by a tab, and wherein each sensor includes an electrode; after punching the polyester substrate to form ribbons, depositing an enzyme layer over the portions of the working electrodes and coating the working electrodes with a glucose limiting membrane; after depositing the enzyme layer over the portions of the working electrodes and coating the working electrodes with a glucose limiting membrane, singulating the individual sensors by completely separating each individual sensor from the polyester substrate.

Detection of hydrogen peroxide or phosphate related compounds in test or clinical samples by using potentiometric sensors wherein the reference electrode and a hydrogen peroxide selective electrode are both connected by a polyelectrolyte positioned in-between. More particularly a potentiometric sensor device for the detection of chemical species in solution with a novel configuration is disclosed.

Detection of hydrogen peroxide or phosphate related compounds in test or clinical samples by using potentiometric sensors wherein the reference electrode and a hydrogen peroxide selective electrode are both connected by a polyelectrolyte positioned in-between. More particularly a potentiometric sensor device for the detection of chemical species in solution with a novel configuration is disclosed.

Various embodiments of the present disclosure are directed to carbon dioxide and/or hydrogen sulphide sampling and detection system and method for determination of the content of gaseous CO2 and/or H2S in a liquid, among other chemical compounds. In one embodiment, the detection system includes a membrane block having a liquid sample inlet port and a sample outlet port between which a sample flow path extends. The membrane block includes a first membrane unit and a second membrane unit. The first membrane unit includes a sample flow on the first side of a first permeable membrane element, and a carrier gas flow on the second side of the first permeable membrane element. The second membrane unit having a sample flow on the first side of a second permeable membrane element and a carrier gas flow on the second side of the second permeable membrane element.

Various embodiments of the present disclosure are directed to carbon dioxide and/or hydrogen sulphide sampling and detection system and method for determination of the content of gaseous CO2 and/or H2S in a liquid, among other chemical compounds. In one embodiment, the detection system includes a membrane block having a liquid sample inlet port and a sample outlet port between which a sample flow path extends. The membrane block includes a first membrane unit and a second membrane unit. The first membrane unit includes a sample flow on the first side of a first permeable membrane element, and a carrier gas flow on the second side of the first permeable membrane element. The second membrane unit having a sample flow on the first side of a second permeable membrane element and a carrier gas flow on the second side of the second permeable membrane element.

A electrochemical sensor (100) for sensing an analyte in an associated volume (106), the sensor comprising a first solid element (126), a second solid element (128) being joined to the first solid element, a chamber (110) being placed at least partially between the first solid element and the second solid element, a working electrode (104) in the chamber (110) and wherein one or more analyte permeable openings (122) connect the chamber with the associated volume (106) and wherein the electrochemical sensor (100) further comprises an analyte permeable membrane (124) in said one or more analyte permeable openings, and wherein the one or more analyte permeable openings are arranged so that a distance from any point in at least one cross-sectional plane to the nearest point of a wall of said opening is 25 micrometer or less.

A electrochemical sensor (100) for sensing an analyte in an associated volume (106), the sensor comprising a first solid element (126), a second solid element (128) being joined to the first solid element, a chamber (110) being placed at least partially between the first solid element and the second solid element, a working electrode (104) in the chamber (110) and wherein one or more analyte permeable openings (122) connect the chamber with the associated volume (106) and wherein the electrochemical sensor (100) further comprises an analyte permeable membrane (124) in said one or more analyte permeable openings, and wherein the one or more analyte permeable openings are arranged so that a distance from any point in at least one cross-sectional plane to the nearest point of a wall of said opening is 25 micrometer or less.

Various example embodiments described herein relate to an electrochemical gas sensor. The electrochemical gas sensor can include a sensor cap having one or more solid features disposed on a surface of the sensor cap. The electrochemical gas sensor can include a counter electrode configured to generate a gas during use of the electrochemical gas sensor. The electrochemical gas sensor can include a vent assembly adapted to release at least a portion of the gas generated at the counter electrode out from the electrochemical gas sensor. The vent assembly can include a vent conduit and a vent membrane that defines a passage for the gas to flow from an extended portion of the counter electrode, to the vent conduit, via the vent membrane, so as to be vented from the electrochemical gas sensor.

Various example embodiments described herein relate to an electrochemical gas sensor. The electrochemical gas sensor can include a sensor cap having one or more solid features disposed on a surface of the sensor cap. The electrochemical gas sensor can include a counter electrode configured to generate a gas during use of the electrochemical gas sensor. The electrochemical gas sensor can include a vent assembly adapted to release at least a portion of the gas generated at the counter electrode out from the electrochemical gas sensor. The vent assembly can include a vent conduit and a vent membrane that defines a passage for the gas to flow from an extended portion of the counter electrode, to the vent conduit, via the vent membrane, so as to be vented from the electrochemical gas sensor.

A moisture regulating electrochemical sensor includes a sensor electrolyte housed in a chamber of a casing configured with electrodes connected electrically to the sensor electrolyte and configured to be connected electrically to an exterior circuit, an inlet, a vent, and a membrane permeable only to moisture, the chamber between the inlet and the vent each to the sensor electrolyte in the chamber, the inlet allowing a target gas to pass through from an exterior target gas environment to the sensor electrolyte in the chamber, and the membrane operatively coupled to the vent, allowing only moisture to translate through the vent between an exterior vent environment and the sensor electrolyte in the chamber.