A data processing method that is suitable for obtaining quantitative information from data obtained by OCT imaging. The image processing method includes acquiring original image data corresponding to a three-dimensional image of a cultured embryo obtained by optical coherence tomography imaging of the embryo and executing a region segmentation the three-dimensional image into a plurality of regions on the basis of the original image data. In the region segmentation, a local thickness calculation is performed on the three-dimensional image to determine an index value indicating a size of an object included in the three-dimensional image, the three-dimensional image is segmented into a region indicated by the index value greater than a predetermined first threshold and a region indicated by the index value less than the first threshold, and each of the regions resulting from the segmentation is further segmented by the watershed algorithm.

Methods, systems, and devices are described for generating an optical signal. An example device may comprise a chip and a waveguide disposed on the chip and comprising silicon nitride. The waveguide may be configured to generate, based on nonlinear effects applied to a pump signal from a pump laser, an optical signal having a broader spectrum than the pump signal. The waveguide may have a width and a height such that the optical signal has near zero group-velocity-dispersion.

The disclosed embodiments relate to multimodal imaging system comprising a fiber-coupled fluorescence imaging system, which operates based on ultra-violet (UV) excitation light, and a fiber-coupled optical coherence tomography (OCT) imaging system. The multimodal imaging system also includes a fiber optic interface comprising a single optical fiber, which facilitates light delivery to a sample-of-interest and collection of returned optical signals for both the fluorescence imaging system and the OCT imaging system. During operation of the system, the single optical fiber carries both UV light and coherent infrared light through two concentric light-guiding regions, thereby facilitating generation of precisely co-registered optical data from the fluorescence imaging system and the OCT imaging system.

A method of multimodal scanning may include generating surface scan data of an intraoral structured using structured light. The method may include generating volumetric scan data of an internal structure of the intraoral structure with OCT scanning. The OCT scan data may be aligned with the surface scan data. A three-dimensional volumetric model of the patient's dentition may be generated based on the aligned OCT scan data and the surface scan data.

A method for characterizing a state of an end effector of an ultrasonic device is disclosed. The ultrasonic device including an electromechanical ultrasonic system defined by a predetermined resonant frequency. The electromechanical ultrasonic system further including an ultrasonic transducer coupled to an ultrasonic blade. The method including applying, by an energy source, a power level to the ultrasonic transducer; measuring, by a control circuit coupled to a memory, an impedance value of the ultrasonic transducer; comparing, by the control circuit, the impedance value to a reference impedance value stored in the memory; classifying, by the control circuit, the impedance value based on the comparison; characterizing, by the control circuit, the state of the electromechanical ultrasonic system based on the classification of the impedance value; and adjusting, by the control circuit, the power level applied to the ultrasonic transducer based on the characterization of the state of the end effector.

The disclosure relates generally to the field of vascular system and peripheral vascular system data collection, imaging, image processing and feature detection relating thereto. In part, the disclosure more specifically relates to methods for detecting position and size of contrast cloud in an x-ray image including with respect to a sequence of x-ray images during intravascular imaging. Methods of detecting and extracting metallic wires from x-ray images are also described herein such as guidewires used in coronary procedures. Further, methods for of registering vascular trees for one or more images, such as in sequences of x-ray images, are disclosed. In part, the disclosure relates to processing, tracking and registering angiography images and elements in such images. The registration can be performed relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT) or intravascular ultrasound (IVUS).

A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly.

In part, the invention relates to a probe suitable for use with image data collection system. The probe, in one embodiment, includes an optical transceiver, such as a beam director, and an acoustic transceiver such as an ultrasound transducer. The optical transceiver is in optical communication with an optical fiber in optical communication with a beam director configured to transmit light and receive scattered light from a sample such as a wall of a blood vessel. The acoustic transceiver includes an ultrasound device or subsystem such as a piezoelectric element configured to generate acoustic waves and receive reflected acoustic waves from the sample.

A delivery fiber assembly suitable for delivering broad band light and including a delivery fiber and a connector member. The delivery fiber has a length, an input end for launching light, and a delivery end. The delivery fiber includes along its length a core region and a cladding region surrounding the core region, the cladding region includes a cladding background material having a refractive index N.sub.bg and a plurality of microstructures in the form of inclusions of solid material having refractive index up to N.sub.inc and extending in the length of the longitudinal axis of the delivery fiber, wherein N.sub.inc<N.sub.bg. The plurality of inclusions in the cladding region is arranged in a cross-sectional pattern including at least two rings of inclusions surrounding the core region. The connector member is mounted to the delivery fiber at a delivery end section of the delivery fiber including the delivery end.

A pulse signal corresponding to rotation of an imaging core is input, and a repetition frequency of the input pulse signal is converted in accordance with the number of radially-aligned lines of an ultrasound tomographic image. Based on the pulse signal of which the repetition frequency has been converted, a drive signal for an ultrasound transceiver is generated to obtain an ultrasound tomographic image with the number of lines. A valid pulse is determined in accordance with the number of lines from the pulse signal of which the repetition frequency has been converted. A signal having a pulse train selected, based on the valid pulse from a pulse signal representing a cycle of a light source of light for interfering with the light from an optical transceiver is generated as a pulse signal representing a timing of sampling of an optical coherence signal for generating an optical tomographic image.