A system and method for diagnosing a sleep disorder in a subject are provided. In some aspects, the method includes sensing electrical signals corresponding to a skin nerve activity in the subject using a plurality of skin electrodes, and generating, using signal detector, signal data using the electrical signals. The method also includes assembling a time-series of data indicating the skin nerve activity using the signal data, and identifying a sleep disorder using the time-series of data. The method further includes generating a report indicative of the sleep disorder.

An example system includes a physiological sensor for generating physiological data associated with a user bearing the physiological sensor. The physiological sensor is configured to wirelessly communicate the physiological data. A portable device includes a touch input device; an accelerometer for generating accelerometer data indicative of activity of the user; wireless communication circuitry for receiving the physiological data; memory for storing the accelerometer data and the physiological sensor data; and a vibrator for providing tactile output to the user. The wireless communication circuitry transmits the physiological data and the accelerometer data to a computer device for use in a presentation application.

A wearable biometric sensing ring apparatus for continuous heart rate and blood pressure monitoring having a ring housing for retention on a finger of a user, a photoplethysmograph (PPG) sensor disposed within the housing on an interior surface of the ring to contact or be placed adjacent the finger to register a pulse rate of the user, a first electrode and second electrode disposed within the housing on said interior surface of the ring to contact the finger on a first side of the user's body, and a third electrode disposed on an exterior surface of the ring housing to contact a contralateral portion of the user's body. A combination of first, second and third electrodes are configured for obtaining electrocardiogram (ECG) measurements. A controller and programming are provided for receiving analog pulse rate data from the PPG sensor and analog ECG data from the first, second and third electrodes, converting the analog pulse rate data and ECG data into digital data, calculating one or more of heart rate (HR), heart rate variability (HRV) and blood pressure (BP) from a combination of the digital ECG and PPG sensor data, and graphically outputting one or more of the calculated HR, HRV and BP.

Described herein is a method for identifying a farm animal having an impairment of regulative capacity in response to metabolic stress, the method including: a) assessing the value of the nonlinear domain heart rate variability component L.sub.MAX of a farm animal based on a heart beat interval data set obtained for the farm animal; and b) comparing the value of L.sub.MAX assessed according to (a) with a species specific threshold of L.sub.MAX, whereby a farm animal having an impairment of regulative capacity will be identified.

A system and method are provided, the system including a monitoring device to monitor sensory data of a patient and to provide a sensory data response thereto, and a control unit configurable to cool or warm circulated fluid through at least one contact pad for thermal exchange with the patient. The monitoring device can be configured to monitor a patient physiological response to a change in temperature of the patient (e.g. pursuant to induced hypothermia therapy), wherein a monitoring signal is provided by the monitoring device. A processor can be provided to process the monitoring signal and provide an output employable by medical personnel. The processor can be programmed to control automatically a temperature of the circulated fluid to cool or warm the patient in different treatment phases in accordance with a predetermined protocol, and process the sensory data signal to provide an output signal indicative of a sensory measurement.

Methods and apparatuses for stimulation of the vagus nerve to treat inflammation including adjusting the stimulation based on one or more metric sensitive to patient response. The one or more metrics may include heart rate variability, level of T regulatory cells, particularly memory T regulatory cells, temperature, etc. Stimulation may be provided through an implantable microstimulator.

Systems and methods for use in measuring sympathetic nervous system activity or blood vessel autoregulation corrected for sympathetic activity. The choroid plexus in the human eye is imaged and, using the resulting image, the vascular perfusion density (VPD) in the choroid is measured. VPD provides a measurement that is directly related to sympathetic nervous system activity. The effect of stimuli on sympathetic nervous system activity can be measured by comparing pre-stimuli VPD measurements with post-stimuli measurements. Quantifying VPD can be performed by determining pixel density within specific areas of the choroid plexus image. Altered sympathetic nervous system activity can be detected in a subject by comparing that subject's VPD measurements to baseline VPD measurements from healthy individuals. Blood vessel autoregulation can be measured by imaging changes in other blood vessels in the eye and correcting with choroid VPD measurements of sympathetic activity.

The present disclosure relates to systems, methods and devices to monitor, diagnose and/or treat diseases or disorders comprising a calibration phase and a real-time diagnostic, treatment or monitoring phase, the calibration phase correlating a plurality of nerve activity measurements from a chronically implanted electrode in a subject with a plurality of concurrent measurements of levels of cytokines and/or glucose in the blood to obtain a functional relationship between blood cytokine and/or glucose levels and vagus nerve activity, and the diagnostic, treatment or monitoring phase analyzing the subject's real-time vagus nerve activity in accordance with the previously obtained functional relationship to initiate a treatment method.

Systems and methods for assessing sympathetic nervous system (SNS) tone for renal neuromodulation therapy are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a detector attached to or implanted in a patient and a receiver communicatively coupled to the detector. The detector can measure cardiac data and the receiver and/or a device communicatively coupled thereto can analyze the cardiac data to provide one or more SNS tone indicators. The SNS tone indicators can be used to determine whether a patient will be responsive to a neuromodulation therapy and/or whether a neuromodulation therapy was effective.

A system and method for training program generation and modification of that program based on assessed functional state and/or workload performance. User-interface logic preferably operating on a mobile device permits a user to record bio-signals indicative of functional state. Assessment-adjustment logic, that may be located at a distance, conducts body system assessments from the received bio-signal data and produces training session targets based on the current functional state of the user. User training objective data may be input through the user-interface logic. Workload performance may be monitored and the training session targets modified based on measured past performance to improve future performance. Various embodiments are disclosed.