A method for inducing an activity of a user's autonomic nervous system is provided. The method includes steps of: (a) on condition that each of the user's reference heart rate information corresponding to each of active states of the user's autonomic nervous system is obtained, an inducing device, if a specific active state of the autonomic nervous system is selected by the user, acquiring first reference heart rate information of the user corresponding to the specific active state of the autonomic nervous system; and (b) the inducing device supporting a first vibration stimulus with a first period corresponding to the first reference heart rate information to be applied to the user, to thereby allow the user's real-time average cardiac interval to be synchronized with the first vibration stimulus.

The present invention collects data on circadian intervals between two cardiac contractions (RR intervals) and, on the basis of the collected data on circadian RR intervals, provides a system for analysis of the human circadian heart rhythm autonomic nervous system balance, and analysis of heart rate (HR). The invention focuses on HR fluctuations that are divided into three groups: slow fluctuations of the circadian period, higher frequencies compared with circadian, and chaotic. The division into parts is executed by applying adequate empiric and mathematical methods to determine a series of envelope curves, closely and individually related to the principal circadian series, followed by their separation from the input HR series, and then applying HR variability (HRV) methods to increase accuracy of the analysis of HRV results and add new HR regulation criteria to the analysis outcomes.

Devices and methods are disclosed that treat a medical condition, such as migraine headache, by electrically stimulating a nerve noninvasively, which may be a vagus nerve situated within a patient's neck. Preferred embodiments allow a patient to self-treat his or her condition. Disclosed methods assure that the device is being positioned correctly on the neck and that the amplitude and other parameters of the stimulation actually stimulate the vagus nerve with a therapeutic waveform. Those methods comprise measuring properties of the patient's larynx, pupil diameters, blood flow within an eye, electrodermal activity and/or heart rate variability.

The present disclosure is directed to a method and apparatus to autonomously stimulate a plurality of nerve fiber groups. The method and apparatus predicts stimulus parameters that can activate 0-100% of the nerve fiber groups selectively according to a patient's characteristics and proportional to therapeutic outcomes, such as determined by experimental data. The method and apparatus may further be configured to input experimental third-party data to obtain a high efficacy from a patient without invasive neurosurgery.

A neurostimulation system includes a programming control circuit and a user interface. The programming control circuit may be configured to generate a plurality of stimulation parameters controlling delivery of neurostimulation pulses according to one or more neurostimulation programs each specifying a pattern of the neurostimulation pulses. The user interface includes a display screen, a user input device, and a neurostimulation program circuit. The neurostimulation program circuit may be configured to allow for construction of one or more pulse trains (PTs) and one or more train groupings (TGs) of the one or more neurostimulation programs, and to allow for scheduling of delivery of the one or more neurostimulation programs, using the display screen and the user input device. Each PT includes one or more pulse blocks each including a plurality of pulses of the neurostimulation pulses. Each TG includes one or more PTs.

Described herein are methods, devices, and systems for treating human anemia. The methods, devices, and systems generally include monitoring a patient's hemoglobin level and at least one of autonomic balance and inflammatory state to determine the etiology of the anemic state, modulating at least one of a sympathetic or parasympathetic nerve based on the cause of the anemia, monitoring for changes in the patient's cardiac activity and state of inflammation, and hemoglobin level. An external neurostimulation system is describes, and well as a chronic implantable system. A method for treating a patient for anemia in conjunction with a renal denervation ablation catheter is also disclosed.

Systems, methods, and devices for neuromodulation are described herein. For example, a method for modulating inflammatory processes of a subject is described. The method can include stimulating the subject's vagus nerve to activate an efferent pathway, and stimulating the subject's vagus nerve to inhibit neural activity. Pairing activation of the efferent pathway and inhibition of neural activity can enhance an anti-inflammatory response of the subject.

A method for measuring stress based on the heart rate (HR), the heart rate variability (HRV), and the activity level of a user includes recording the HR, the HRV, and the activity level of a user at various times during the day. Thereafter, the three values are correlated to arrive at a stress level of the user. The stress level is estimated based on a predetermined set of algorithms and analysis methods. The physical disposition and the activity levels of the user are automatically detected and the vital parameters, i.e., the HR and the HRV recorded at times that are deemed fit for conducting orthostatic tests.

In one embodiment, a cardio-adaptive non-invasive positive airway pressure device comprises an airflow generator to provide pressurized air to a human. A detector detects a cardiac cycle of the human. A control unit estimates a next cardiac cycle based on the detected cardiac cycle and provides a control signal to the air flow generator to control timing of the providing of the pressurized air to the human based on the estimated cardiac cycle.

Apparatus for improving health of a user is provided, including a first sensor, adapted to measure a first physiological variable, which is indicative of a voluntary action of the user. A second sensor is adapted to measure a second physiological variable, which is substantially governed by an autonomic nervous system of the user. Circuitry is adapted to receive respective first and second sensor signals from the first and second sensors, and, responsive thereto, to generate an output signal which directs the user to modify a parameter of the voluntary action.