The chemical sensing device comprises a substrate of semiconductor material, integrated circuit components and a photodetector formed in the substrate, a dielectric on the substrate, a wiring in the dielectric, and a source of electromagnetic radiation, a waveguide and a fluorescent sensor layer arranged in or above the dielectric. A portion of the waveguide is arranged to allow the electromagnetic radiation emitted by the source of electromagnetic radiation to be coupled into the waveguide. A further portion of the waveguide is arranged between the photodetector and the fluorescent sensor layer.

Composition, systems, and methods for the induction of biological endpoints in a cheap contained system. In many embodiments, variation on well numbers on plates and ranging ultraviolet wavelengths produces different and controlled outcomes of the biological endpoint induction. Endpoint induction of this type allows for chemical induction, wherein the system can be turned on and off in short time periods.

A method of microscopy comprises collecting an emission light; symmetrically dispersing the collected emission light into a first order (“1.sup.st”) light and a negative first order (“−1.sup.st”) light using a grating; wherein the 1.sup.st light comprises spectral information and the −1.sup.st light comprises spectral information; capturing the 1.sup.st light and the −1.sup.st light using a camera, localizing the one or more light-emitting materials using localization information determined from both the first spectral image and the second spectral image; and determining spectral information from the one or more light-emitting materials using the first spectral image and/or the second spectral image; wherein the steps of localizing and obtaining are performed simultaneously. A spectrometer for a microscope comprises a dual-wedge prism (“DWP”) for receiving and spectrally dispersing a light beam, wherein the DWP comprises a first dispersive optical device and a second dispersive optical device adhered to each other.

A suitable fluorescence separation method is set according to an object to be measured. An information processing device according to an embodiment includes a separation unit (14) that calculates, from a fluorescence signal measured from a biological sample labeled with one or more fluorescent dyes, fluorescence intensities of one or more fluorescent beams and an autofluorescent beam emitted from the one or more fluorescent dyes and the biological sample, respectively, by an arithmetic operation using a least squares method using a fluorescence spectrum reference of each of the fluorescent dyes and an autofluorescence spectrum of the biological sample. In the arithmetic operation using the least squares method, an upper limit value and a lower limit value of the fluorescence intensity are set for each of the one or more fluorescent beams and the autofluorescent beam.

Systems and methods include a fluorescence measurement apparatus. A single-wavelength light source generates an excitation light source. A sample holder holds a sample and includes a surface transparent to the excitation light source. Mounts attached to the single-wavelength light source(s) or the sample holder change an incident angle of the excitation light source on the surface. Optical components positioned in a path of a fluorescence emission emitted from the surface guide the fluorescence emission to a detector that obtains spectra from at least first and second angles-of-incidence. A device records spectra obtained by the detector from the first and second angles-of-incidence, normalizes and analyzes intensities of the spectra, subtracts a first spectrum corresponding to the first angle-of-incidence from a second spectrum corresponding to the second angle-of-incidence to obtain a difference, identifying a sample type of the sample based on an API gravity mapped to the difference.

There is provided a technology that supports selection of a label to be used for analysis of target molecules.

The present technology provides a label selection support system including an information acquisition unit that obtains, via a network, information associated with a plurality of target molecules to be analyzed, an information processor that obtains, using the information associated with a plurality of target molecules, in vivo expression information of the plurality of target molecules from a database storing in vivo expression information of target molecules and generates support information associated with assignment of a label to each of the plurality of target molecules on the basis of the expression information, and a transmitter that transmits the generated support information via the network.

Methods and systems for analysing products comprising marked materials and marking and tracking such materials are provided. A method of quantifying the proportion of a marked material comprising luminescent markers in a product comprises (i) obtaining a composite signal associated with the product, the composite signal including spectroscopic data and imaging data collected from the product, the spectroscopic and imaging data associated with a luminescent signal of the one or more luminescent markers in the marked material; (ii) identifying the marked material based on spectroscopic data associated with the one or more luminescent markers; (iii) quantifying the proportion of the marked material that is present in the product based at least in part on said imaging data of the composite signal, wherein said quantifying is based at least in part on the relative positions of and/or the number of luminescent markers detected in each image of the product.

The present disclosure discloses a sensor holder for a flow sensor, comprising a substantially cylindrical housing with a housing interior with an opening at a first front face. The opening is designed to receive the flow sensor. The housing at the second front face, which is opposite the first front face, is conical. A first flushing opens to the housing interior, where the opening opens into the end region of the cone, and a second flushing opens to the housing interior. A fastening unit is designed to fasten the flow sensor in the housing, and a first wall holder is designed to be fastened to a wall. The first wall holder comprises a joint in the region of the second front face, with the joint connecting to the housing. The housing can be moved via the joint from a measurement position into a maintenance position.

Preparing and analyzing a fluid for a multi-spectral analysis is disclosed. The multi-spectral analysis includes providing two or more separate and independent types of spectroscopies including at least a first spectrometer and a second spectrometer of a spectrometer system to examine the fluid after that fluid has passed through one or more sample preparation processes to increase a purity of a target biological entity in the fluid and thereby enhance signal to noise ratios in measurements and related data analysis operations.

A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir, (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.