A method of detecting at least one analyte in a test sample is provided comprising a) contacting the test sample (i) to an active chemistry matrix changing at least one electrochemical property dependent on an enzymatic activity active in the presence of the analyte, the active chemistry matrix contacting a first electrode; and (ii) to an inactive chemistry matrix, the inactive chemistry matrix contacting a second electrode, b) closing an electrical circuit including the first electrode, the second electrode, and the active chemistry matrix and inactive chemistry matrix, followed by determining a first value of the at least one electrochemical property, c) inverting electrical polarity of the electrical circuit of b), followed by determining a second value of the at least one electrochemical property, and d) detecting the at least one analyte based on the first value and on the second value.

According to one embodiment, a molecule detecting device includes a capturing section, a releasing section, and a detecting section. The capturing section is configured to, by combining a target molecule and a solubilizing agent with each other and thereby creating a composite body, capture the target molecule in a carrier liquid. The releasing section is configured to make the composite body release the target molecule therefrom in the carrier liquid. The detecting section is configured to carry out detection of the target molecule in the carrier liquid.

A sex toy collects a body fluid and/or cells as present in a genital, especially in a female vagina, for a diagnostic test, especially an in-vitro diagnostic test and/or a biomarker test. The sex toy includes a housing having at least one sampling port leading into at least one sampling channel for collecting a sample of body fluid and/or cells through the sampling port and the sampling channel inside the housing. The sex toy includes a test module adapted for analyzing and/or screening and/or monitoring diagnostic parameters of a collected sample body fluid and/or cells with medical implications as well as general health and lifestyle parameters. The test module includes comprising at least a first analyzing unit for carrying out a diagnostic test.

Diagnostic devices for quantitative or qualitative analysis of a sample fluid including an analyte include at least two portions made from a hydrophilic material. The planar portions are stacked on each other and each occupy a different and substantially parallel plane to form a three-dimensional structure. At least one of the planar portions includes a hydrophobic region formed by applying a low surface energy material that extends through a thickness of the substrate portion from a first major surface to a second major surface thereof. The hydrophilic regions in the overlying substantially parallel substrate portions can be aligned with each other such that a fluid is passively transported between adjacent hydrophilic regions to provide a sample flow path between adjacent substrate portions.

Examples of the disclosure relate to an apparatus for providing electrical input signals to a biological sample so as to provide a plurality of corresponding electrical output signals. The apparatus is configured so that the electrical output electrical signals have passed through the biological sample. This means that the electrical output signals comprise of information about the properties of the biological sample. In examples of the disclosure, the electrical input signal can be controlled so that the electrical output signals comprise of general features and sub-features that enable characteristics of the biological sample to be identified. The use of these general features and sub-features can enable the characteristics to be identified without creating a reconstruction of the biological sample.

A biosensor using an exceptional point is disclosed. A biosensor according to one embodiment of the present disclosure includes: a biosensing unit configured to output wavelength-separated optical signals from destruction of an exceptional point resulting from attachment of biomolecules; a detection unit configured to convert the wavelength-separated optical signals into wavelength-separated electrical signals; an analysis unit configured to measure a beat frequency resulting from the wavelength-separated electrical signals; and a determination unit configured to determine a wavelength difference resulting from the beat frequency, thereby determining the amount of the biomolecules therefrom.

Systems and methods of assessing a probability that an individual will develop sepsis are provided. The systems and methods can include obtaining a set of parameters associated with the individual including white blood cell count (WBC) and monocyte distribution width (MDW) value, and determining whether the set of parameters provides an elevated risk status by comparing at least the WBC and the MDW value with respective predetermined criteria. In the event that the set of parameters is determined to provide the elevated risk status, the systems and methods can further include obtaining a secondary parameter associated with the individual; and providing the probability that the individual will develop sepsis.

Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.

Embodiments provide detection systems and methods for detecting the presence of a nucleic acid in one or more samples. In a detection method, a sample and one or more nucleic acid probes are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of a nucleic acid in the channel is determined based on a comparison between the first and second electrical property values.

A portable biosensor for detecting and quantifying a target molecule in a biological sample and method of use include a biosensor fabricated with a recognition layer with an imprinted polymer, an electrode electrically coupled to the recognition layer, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon, wherein the imprinted polymer is shaped to have a profile that substantially matches a profile of the target molecule, such that the target molecule can form-fit and bind to the imprinted polymer, thus changing an electrical property of the polymer layer that may be detected to identify the presence of the target molecule.