In an electrophoresis apparatus using a capillary, electrophoresis using a single capillary sometimes requires replacement of a sieving matrix. Replacement with a different sieving matrix has conventionally required cleaning with sieving matrix cleaning liquid, which has increased costs and time required. An electrophoresis apparatus according to the present invention comprises an anodic capillary head provided at a distal end of the capillary, a sieving matrix container filled with a sieving matrix used for electrophoresis, and a filling mechanism for filling the capillary with the sieving matrix via the sieving matrix container. The filling mechanism fills the capillary, which is already filled with the sieving matrix, with a sieving matrix different from the already-filled sieving matrix without using sieving matrix cleaning liquid.

The present invention relates to a Micro-Free Flow Electrophoresis chip for analyzing or separating a sample including a pile (1) comprising at least two plates (2A, 2B), a sheet (3) uniformly disposed between the two plates (2A, 2B), clamping means, each sheet (3) comprising at least two inlets (11) for entry and at least one outlet (12) for exit of a first fluid electrode and a second fluid electrode, the first and second fluid electrodes applying an electric field to a separation chamber (31).

A method of driving an element of an active matrix electro-wetting on dielectric (AM-EWOD) device comprise applying a first alternating voltage to a reference electrode of the AM-EWOD device; and either (i) applying to the element electrode a second alternating voltage that has the same frequency as the first alternating voltage and that is out of phase with the first alternating voltage or (ii) holding the element electrode in a high impedance state. The effect of applying the second alternating voltage to the element electrode is to put the element in an actuated state in which the element is configured to actuate any liquid droplet present in the element, while the effect of holding the element electrode in the high impedance state is to put the element in a non-actuated state.

A system may include a first conduit configured to form a first batch of discrete volumes of aqueous fluid separated by spacing liquid disposed between consecutive volumes of aqueous fluid, the spacing liquid being immiscible with the aqueous fluid volumes; a second conduit, fluidically coupled to the first conduit, the second conduit configured to statically hold the first batch of discrete volumes of aqueous fluid; and a third conduit configured to receive the first batch of discrete volumes of aqueous fluid from the second conduit. The third conduit can be configured to transfer the discrete volumes of aqueous fluid of the first batch for downstream processing.

An automated method and system for identifying one or more chemical tracers present in a sample drawn downstream from the well head from a produced hydrocarbon oil/water stream in a pipeline from a downhole well completion, the one or more chemical tracers having originally been applied to the outer surface of one or more lengths of tubing placed at known locations in the assembly of the downhole well completion, the chemical identification of each of the tracers and the location of each of the tracers having been retrievably recorded for the well completion in the form of a relational database, by in situ testing of a portion of the aqueous layer of the sample following settling by means of an electrophoresis analysis system that includes a micro-fluidic chip and an electronic data information collection unit and signal communication means for transmitting conditioned data from the electronic data information collection unit to the central control station for comparison with, and identification of data associated with the chemical tracers and the location of the chemical tracers in the well completion from the relational database, and a user display device for displaying the results of the data comparison and identification so that appropriate remedial action to reduce the volume of produced water in the hydrocarbon stream can be taken.

The present disclosure provides component analysis methods including a measurement process and an analysis process.

When measuring electrophoretic mobility it is customary to apply an electric field and determine the electrophoretic velocity while minimizing all other contributions to the particle movement. A method and apparatus for the measurement of mobility while the sample is flowing is disclosed. Combined with a fractionation system, this approach further enables the direct measurement of individual species' mobility within a multi-modal sample. Other advantages of this new mobility measurement approach include the ability to easily pressurize the sample to suppress electrolysis, mitigation of oxidation-reduction effects and efficient heat dissipation.

A system comprising a protein and a channel. The channel has a domain that binds a membranal component. The channel is configured to carry a liquid sample to an isotachophoresis (ITP) apparatus. The liquid sample comprising or suspected of comprising a cell, a cell membrane or a fraction of a cell membrane. The ITP apparatus comprises a first zone and a second zone. The first zone is configured to contain a solution of high effective mobility leading electrolyte (LE) ion. The second zone is configured to contain a solution of low effective mobility trailing electrolyte (TE) ion. The first zone and the second zone are configured to be operably connected to at least one anode and at least one cathode.

A method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The discrete volumes are separated from one another by a liquid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.

A digital microfluidic system includes a substrate, a plurality of electrode sets provided on the substrate, wherein each of the electrode sets includes two co-planar interdigitated finger electrodes, and a driving circuit including an AC/DC voltage source and a controller. Each of the electrode sets is individually addressable by the driving circuit under control of the controller such that an AC/DC voltage generated by the AC/DC voltage source may be selectively provided to one or more of the electrode sets. Also, an anti-biofouling electrode for a digital microfluidic system includes an electrode layer, and a slippery liquid infused porous surface structure provided on the electrode layer.