A method of analyzing a molecule is disclosed. A lipid bilayer is formed such that it divides a first reservoir characterized by a first reservoir osmolarity from a second reservoir characterized by a second reservoir osmolarity. An electrolyte solution is flowed to the first reservoir that tends to make a first change to a ratio of the first reservoir osmolarity to the second reservoir osmolarity. A voltage is applied across the lipid bilayer, wherein the lipid bilayer is inserted with a nanopore, and wherein a net transfer of ions between the first reservoir and the second reservoir tends to make a second change to the ratio of the first reservoir osmolarity to the second reservoir osmolarity, and wherein the first change to the ratio and the second change to the ratio tends to counter-balance each other.

A capillary electrophoresis system includes a capillary reservoir. The capillary reservoir includes a capillary tip flow chamber configured to receive respective capillary tips and to conduct fluid past the capillary tips, and an electrode flow chamber in which an electrode is disposed and configured to conduct fluid past the electrode, the electrode flow chamber being separate from and in fluid communication with the capillary tip flow chamber. An ultraviolet (UV) light absorbance-based multiplexed capillary electrophoresis system includes a first enclosure and a second enclosure. The first enclosure covers a UV light source, and includes a slit. The second enclosure covers the first enclosure, a collimating lens, and a capillary window.

An electrophoresis apparatus includes: a sample plate including a sample receptacle; a protective sheet; a rack that supports the sample plate; a cover mounted on the protective sheet; a rack receiving mechanism that receives the rack; a punch pin; a dispensing probe; and a chip holder, and the rack receiving mechanism includes: a rack holder that removably holds the rack; and an urging portion that urges the cover toward the sample plate while the rack is held by the rack holder.

A capillary electrophoresis device includes: a plurality of capillaries; a light source; a detector that detects light transmitted through the capillaries; an optical coupling optical system and a plurality of first optical fibers provided between the light source and the plurality of capillaries; and a plurality of second optical fibers provided between the plurality of capillaries and the detector. The optical coupling optical system couples the light from the light source to the plurality of first optical fibers. Each of the plurality of first optical fibers has a first end face connected to the optical coupling optical system, and a second end face arranged close to and opposite to a corresponding capillary among the capillaries. Each of the plurality of second optical fibers has a first end face arranged close to and opposite to a corresponding capillary among the capillaries, and a second end face connected to the detector.

The disclosure provides detection apparatus having one or more nanopores, methods for making apparatus having one or more nanopore and methods for using apparatus having one or more nanopores. Uses include, but are not limited to detection and sequencing of nucleic acids.

A display method for displaying a plurality of pieces of data respectively obtained by electrophoretic separation for a plurality of samples. The first data includes a first peak corresponding to a separated component of the known sample. The second data includes a second peak corresponding to a separated component of the unknown sample. The display method includes: acquiring the plurality of pieces of data; detecting the first peak and the second peak respectively from the first data and the second data; setting a range included within a predetermined threshold from the first peak as a specified range; determining, for the second data, whether or not the second peak is included in the specified range; and displaying specifically the second peak, when the second peak is in the specified range.

A device and a method is provided for profiling particles such as proteins. The device comprises: a liquid chromatography column (16) in a mixture separation module (10); a fractionation device (22, 24) and a plurality of microfluidic analysis modules (26, 28) in a microfluidic network (14). The microfluidic analysis modules are configured to provide multi-dimensional analysis of the particles. Furthermore, a fluidic flow adaptor (20) allows for controlled flow between separator (16) and the microfluidic network to provide a continuous fluid flow.

An electrophoresis apparatus with minimal autofluorescence to enable gel processing in situ, and methods of making and using the electrophoresis apparatus. An exemplary electrophoresis apparatus may comprise a cassette defining a cavity between a first pane and a second pane of a double-paned viewing window, and also may comprise a slab gel located in the cavity. The viewing window may be transparent to ultraviolet light that drives a derivatization reaction in the slab gel, and, absent the slab gel, may define a window autofluorescence inducible by irradiation with the ultraviolet light. The window autofluorescence, per unit area, may be less than five-fold a gel autofluorescence of the slab gel, per the same unit area and under the same irradiation with the ultraviolet light.

Provided is an electrophoresis device that, by electrophoresis, feeds a sample into capillaries and optically detects the sample, the electrophoresis device being provided with capillaries, a capillary head provided at the distal end of the capillaries, a phoretic medium-filled container used for electrophoresis and filled with a phoretic medium, a guide member that covers the side surface of the phoretic medium-filled container, a seal member that seals from below the phoretic medium filled in the phoretic medium-filled container, and a plunger that presses the seal member.

Provided is an electrophoresis device for enhancing its analysis performance. In order to achieve the task, the electrophoresis device includes a capillary array constituted by a capillary, a capillary head for bundling an end of the capillary, an electrode holder for holding an electrode provided at the other end of the capillary and a detector provided for the capillary, a first heater for heating the capillary, and an irradiation detection unit for irradiating a light to the detector to detect a fluorescence generated from a fluorescence labelled sample in the capillary. The electrophoresis device further includes a second heater for heating the detector.