This invention relates to assays for a Plasmodium analyte in a liquid sample such as a body fluid. More particularly, the invention relates to a method and apparatus for the detection of a ligand in a body fluid such as urine or blood, which can diagnose malarial infection.

Methods for using focused light scattering techniques for the optical sensing of biological particles suspended in a liquid medium are disclosed. The optical sensing enables one to characterize particles size and/or distribution in a given sample. This, in turn, allows one to identify the biological particles, determine their relative particle density, detect particle shedding, and identify particle aggregation. The methods are also useful in screening and optimizing drug candidates, evaluating the efficacy and dosage levels of such drugs, and in personalized medicine applications.

The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

A blood analyzing device (100) comprises a light source (120) arranged to generate light (40) of a wavelength at which a Hb species in a hemolyzed blood sample (30) has absorbance. A detector system (130) is arranged to detect output light (50) from the sample (30) and generate a Hb signal representative of an amount of the Hb species in the sample (30) and a parasite signal representative of an amount of malaria parasites in the sample (30). A processor (140) generates a red blood cell value based on the Hb signal and generates a parasitemia value based on the parasite signal and the red blood cell value. A display (160) displays the parasitemia value representing a percentage of the red blood cells that are infected by malaria parasites.

The present disclosure provides novel antigenic peptides and peptide mixtures, and methods of use for the detection of T. cruzi antibodies in tissue samples and the diagnosis of Chagas disease in a subject.

The present invention provides compounds, methods for their preparation, methods for their use and compositions containing them, which are suitable for industrial application in the pharmaceutical and diagnostic/prognostic field, particularly for the detection and diagnosis of Toxoplasma gondii infections, as well as for the treatment and prevention of said infections.

Methods for detecting the presence or absence of an intestinal parasite infection in a mammalian sample are disclosed herein. The methods can be used to confirm the presence or absence of an intestinal parasite by applying a first test that is an immunoassay or a nucleic acid assay and conducting a second test such as microscopic evaluation assay based on the outcome of the first test or based on one or more evaluation metrics. Confirmation of the presence or absence of the intestinal parasite in the mammal can be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.

The invention relates to a method for detecting antibodies against Leishmania in a biological sample. The invention further relates to a test for carrying out the method, the production of the test antigen, and the test antigen with SEQ ID NO. 8.

The present disclosure is directed to an airborne detection device, method, and system for analyzing an environmental air sample and detecting airborne pathogens. The device includes an analysis vial, and a biosensor electrode. The system further includes an external sampling device.