Compositions for detecting agents causing lymphatic filariasis, including Wuchereria bancrofti, are provided, including the antigen Wb5 or fusion proteins including Wb5 linked to a reporter protein or tag. Nucleic acids encoding the Wb5 protein or the fusion proteins, vectors including the nucleic acids, and host cells including the nucleic acids or vectors are also provided. Methods of detection of antibodies to Wb5 in a sample from a subject, including immunoassay methods are also provided.

The present invention provides methods for detecting an anti-Schistosoma antibody in a sample obtained from a subject. Corresponding compounds, compositions, kits and methods for monitoring a subject to determine if they have contracted a Schistosoma infection are also provided.

Point-of-care (POC) testing for T. gondii infection can potentially address cost concerns and lead to better clinical outcomes through improved access to screening. This disclosure provides methods and compositions for whole blood POC testing to identify T. gondii infection with high sensitivity and specificity, obviating the need for venipuncture and sample processing infrastructure, making it an efficient, low-cost POC test.