Point-of-care (POC) testing for T. gondii infection can potentially address cost concerns and lead to better clinical outcomes through improved access to screening. This disclosure provides methods and compositions for whole blood POC testing to identify T. gondii infection with high sensitivity and specificity, obviating the need for venipuncture and sample processing infrastructure, making it an efficient, low-cost POC test.

A method for detecting a malaria infection whereby providing a mouth cleansing product to a user then asking the user to blow or breathe onto or into a capture mechanism, wherein the capture mechanism may contain a thioether detection mechanism such as Michler's Hydrol; and analyzing whether a thioether detection mechanism displays any loss of the thioether detection mechanism. The invention also discloses a kit for indicating the presence of malaria by instructing the user to exhale through a capture mechanism after using a mouth cleansing product, wherein the kit includes a thioether detection mechanism such as Michler's Hydrol.

Disclosed is a blood analyzer that includes: a sample preparation unit configured to mix a blood specimen and a fluorescent dye for staining nucleic acid to prepare a measurement sample; a light receiver configured to receive fluorescence and scattered light that are generated by light being applied to the measurement sample prepared by the sample preparation unit; and a controller programmed to determine whether or not infection with Plasmodium has occurred, on the basis of a value representing variation of a distribution of first particles in a range where single-ring form of red blood cells appear, the range where single-ring form of red blood cells appear being identified according to fluorescence intensities and scattered light intensities obtained by processing of signals from the light receiver.

The present invention relates to methods and compositions for preventing, treating and diagnosing infection by trypanosomes. The invention also relates to the use of excreted/secreted antigens (exoantigens, secretome) and specifically to the identification of a protein excreted/secreted by the trypanosomes, the inhibition of which makes it possible to provide effective protection, mainly by vaccination, against infection by trypanosomes or the development or spread thereof. The invention relates to use of the protein, the derivatives thereof, a nucleotide sequence derived from said protein, or an extract enriched with said protein, and to the use of antibodies directed against said trypanosomes for immunotherapy, diagnosis, and monitoring of infections by trypanosomes.

The present invention relates to a preferably computer-implemented method of raising a group of monogastric animals Issues such as exposure of the animals to an initiator of a disease are recognized at an early stage by ex vivo analysis of blood samples. Said analysis is done where the animals are raised using point-of-care devices. Accuracy of separation between affected and non-affected animals is increased by measuring a set of pre-determined blood parameters. The landless monogastric animal production system of the invention facilitates implementation of the method of the invention.

A portable device for detecting and/or quantifying hemozoin by optical reflectance spectrophotometry, directly on the patient's skin, on tissues or in a liquid sample which comprises means for calibrating the device; at least one optical emitter to excite the sample; at least eight optical detectors to detect the reflectance spectrum of the sample; at least eight bandpass optical filters to filter the reflected light for each optical detector; wherein the optical filters and optical detectors are aligned with each other, wherein the emitter and optical detectors are positioned allowing reflection of the emitted light towards the optical detectors, wherein the optical filters and optical detectors comprise wavelengths between 400 nm and 800 nm; and a microcontroller configured to calculate a ratio between the reflectance values of the sample at each wavelength to detect the reflectance peaks. Also disclosed is a method of detecting and/or quantifying hemozoin by optical reflectance spectrophotometry.

Disclosed herein are systems, methods and kits for detecting and monitoring pathogens, such as bacterial, fungal and viral foodborne pathogens.

The present invention provides a composition for multiplex diagnosis of Toxoplasma gondii and/or influenza virus, comprising virus-like particles (VLPs) that comprise a T. gondii surface antigen protein, and VLPs that comprise an influenza virus M1 protein. In one embodiment, the VLPs comprise at least one protein from the group consisting of TgAMA1 VLP, TROP4 VLP and TgROP18. The composition for multiplex diagnosis can react, with high sensitivity and specificity, to biological samples isolated from individuals infected with T. gondii and individuals infected with Influenza virus. Therefore, the composition for multiplex diagnosis can be used in a kit for multiplex diagnosis of toxoplasmosis and/or Influenza virus.

Embodiments of the present disclosure are directed to ferrofluid-based assay methods, systems and device for detecting one or more parasite oocyst or egg, and more specifically, to detecting parasite oocysts or eggs in fecal matter of livestock, so as to determine parasitic infections within such livestock. Such embodiments are configured to help in the ability to maintain healthy livestock for human consumption.

The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.