Provided are: an array, a kit, and/or a device which are for analyzing, identifying, detecting, and/or visualizing target particles, and/or determining the presence or absence of the target particles, and use a substrate having an uneven surface coated with a lipid bilayer; and a method using same.

The present invention relates to a system capable of performing simple and rapid inspection of an antigen equivalent to the immune chromatographic method with accuracy good as a PCR method. An embodiment relates to a novel fluorescence counting system for quantifying viruses or antibodies in an analyte which comprises an unit of providing an antigen or antibody phase solidified substrate by an aggregation method with quantum crystals, an unit for making a labeling liquor and labeling a virus or an antibody to be measured in the analyte by an antigen-antibody method, an unit of exciting the fluorescently labeled virus or antibody by a surface plasmon excitation method, and an unit of counting fluorescent points in an excited fluorescent screen to quantify the virus or antibody in the analyte.

Disclosed herein are compositions comprising a compound of Formula (I) and methods for treating or prophylaxis of porcine reproductive and respiratory syndrome (PRRS) therewith (I).

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The present disclosure discloses recombinant peptides and proteins comprising coronavirus viral antigens and immunogens, e.g., coronavirus S protein peptides, useful for analyzing an analyte such as neutralizing antibodies. In some aspects, the recombinant peptides and proteins comprise a secreted fusion protein comprising a soluble coronavirus viral antigen joined by in-frame fusion to a C-terminal portion of a collagen which is capable of self-trimerization to form a disulfide bond-linked trimeric fusion protein. Diagnostic methods and related kits are also disclosed.

Disclosed are novel targets for coronavirus therapies and methods of their use in screens for novel inhibitors of coronaviral infections. Also disclosed are novel coronavirus inhibitors that interact with said targets.

Compositions that selectively bind to coronaviruses, including but not limited to SARS-COV-2 and methods of use thereof are provided. The disclosed antibodies and antigen-binding fragments were developed against SARS-CoV-2. The antibodies bind to the spike protein of coronaviruses. The disclosed antibodies are useful for diagnosing, detecting, preventing, and treating coronavirus infections.

Generation of monoclonal antibodies, or fragments thereof, that recognize the PB2 protein of the human influenza virus (Flu), where the monoclonal antibodies or fragments thereof, has a heavy chain variable region and light chain variable region. Furthermore, a diagnostic method is provided to detect Flu infections in biological samples of nasopharyngeal secretions, using monoclonal antibodies in diagnostic kit format.

A high-throughput high sensitivity and high selectivity ELISA-based method is provided that can detect human IgA, IgM, and IgG directed against SARS-CoV-2 with minimum false positive results. Simultaneous use of SARS-CoV-2-specific antigens derived from SARS-CoV-2 spike and nucleocapsid proteins provides greater sensitivity and selectivity compared to current methods for the detection of SARS-CoV-2-induced human immunoglobulin A, M, and G serum antibodies.

Provided are devices for assessing the presence of SARS-CoV-2 in a biological sample, the devices comprising a substrate comprising a top surface and a back surface; and, an electrode on the top surface of the substrate, wherein the electrode is functionalized with a detection moiety that binds SARS-CoV-2 spike protein. Also disclosed are articles that include such devices, and methods for assessing the presence of SARS-CoV-2 in a biological sample using the disclosed devices. The present disclosure also provides devices for assessing the presence of herpes simplex virus (HSV) in a biological sample comprising a substrate that includes a top surface and a back surface; and, an electrode on the top surface of the substrate, wherein the electrode is functionalized with a detection moiety that binds HSV glycoprotein gD2, such as nectin-1. Also disclosed are articles that include such devices, and methods for assessing the presence of HSV in a biological sample using the disclosed devices.

Provided is a method for screening a modulator of a viral infection by detecting an interaction of angiotensin converting enzyme 2 (ACE2) and a spike protein with a biosensing platform. Also provided is a compound of formula (I) as a modulator of a viral infection, where R, X, A, R.sub.3 to R.sub.5, and m are as defined herein, and a method for protecting a subject from a viral infection by administering with the compound.

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