A transplantation method to increase the establishment rate of human tumors in immunodeficient mice. A pocket is created in the mouse and the tumor and surrounding tissues are implanted in the pocket. The pocket is left open to oxygenate the tumor and surrounding tissues.

The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Provided herein are compositions, systems, kits, and methods for performing an activity based on detecting, in a sample from a cancer patient, the presence of elevated levels of Lactotransferrin (LTF) mRNA or protein, or detecting the presence in the MIF promoter region of at least one of: 173C and 794 CATT.sub.5-8, and treating a patient with immunotherapy, or generating a report that the subject should be treated with immunotherapy.

A monoclonal antibody inhibiting an SMIM15 and application thereof; the antibody is secreted by a hybridoma cell strain 1M5. A preparation method includes: preparing mouse immunogen and an antigen for detection; preparing the hybridoma cell strain 1M5 against an SMIM15; screening an SMIM15 positive monoclonal antibody: identifying a subtype of the monoclonal antibody; detecting specificity of the SMIM15 positive monoclonal antibody; producing and purifying the monoclonal antibody in a BALB/c mouse; detecting purity of the antibody by SDS-PAGE; and performing function identification and application on the SMIM15 monoclonal antibody with WB, IHC and ELISA. According to the present application, the antibody secreted by the hybridoma cell strain 1M5 is an immunoglobulin, which is non-toxic, and can be used for Western blot and immunohistochemistry and used as an active ingredient to be made into a reagent or drug for diagnosis and treatment of SMIM15-related diseases.

Disclosed herein are non-myeloablative antibody-toxin conjugates and compositions that target cell surface markers, such as the CD34, CD45 or CD117 receptors, and related methods of their use to effectively conditioning a subject's tissues (e.g., bone marrow tissue) prior to engraftment or transplant. The compositions and methods disclosed herein may be used to condition a subject's tissues in advance of, for example, hematopoietic stem cell transplant and advantageously such compositions and methods do not cause the toxicities that are commonly associated with traditional conditioning methods.

Provided are a method, an apparatus, and a kit for detecting a neuroblastoma in a subject and/or for monitoring a therapeutic effect on the neuroblastoma, by measuring a urinary tumor marker(s) in a sample from the subject.

This invention relates to methods for treating subjects with breast cancer, based on tumor expression levels of chemokines.

The present invention is directed to therapeutic methods using IL-6 antagonists such as anti-IL-6 antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat anemia (e.g., anemia associated with chemotherapy) including persons on a treatment regimen with a drug or chemotherapy and/or radiation for cancer (e.g., head and neck cancer) that is associated with increased risk of anemia.

A molecular probe for use in detection of cancer cells expressing an Ig superfamily cell adhesion molecule that binds in a homophilic fashion in a subject includes a targeting agent that specifically binds to and/or complexes with a proteolytically cleaved extracellular fragment of the Ig superfamily cell adhesion molecule.