A detector assembly and method of detecting the presence of a biomarker, such as bilirubin, in a sample of a flowable substance and a detector unit (1) are disclosed. The method comprises providing a receiver body (2) shaped to define a receiving chamber (3). The receiving chamber (3) has an outlet opening (5) through which a flowable substance can leave the receiving chamber (3). The receiving chamber (3) has a maximum capacity for holding a volume of the flowable substance. A quantity of the flowable substance is supplied to the receiving chamber (3) and caused to pass through the outlet opening. The receiver body (2) can move relative to a guide (10) of the receive body (2) from a first position in which the outlet opening (5) is blocked to a second position in which the outlet opening (5) is not blocked. In the second position, a metered quantity of flowable substance in the receiving chamber (3) can leave the receiving chamber (3).

Improved analyte detection system within a blood gas analyzer, the improved system comprising and/or consisting of at least one CO-oximetry system that is formed as an integrated, unitary structure(s) with an electrochemical sensor module, and methods of use related thereto.

A sample collection device includes a grip portion and a collection portion connected to the grip portion, wherein the collection portion includes a first surface and a capillary having a groove shape provided on the first surface and formed with openings at opposite ends thereof.

In one aspect, a sensor for detecting hemoglobin protein (e.g., human hemoglobin protein) in a sample is disclosed, which includes a graphene layer, a plurality of binding agents coupled to said graphene layer to generate a functionalized graphene layer, where the binding agents exhibit specific binding to a hemoglobin protein (e.g., to human hemoglobin protein) and a plurality of electrical conductors electrically coupled to said functionalized graphene layer for measuring an electrical property (e.g., DC electrical resistance) of said functionalized graphene layer. While in some embodiments such binding agents are monoclonal antibodies, in other embodiments they can be polyclonal antibodies.

A method and system for determining a concentration of one or more analytes in whole blood is provided. In one aspect of the invention, the system includes a channel configured to carry whole blood. The system further includes a light source configured to emit light on the channel. Additionally, the system includes an actuation module associable with the channel, wherein the actuation module is configured to generate a cell-free plasma layer in the channel. Furthermore, the system includes an optical module associable with the channel.

The present disclosure is directed to a thin-film element that enables analytes to be analyzed on separate surfaces. In an example, a thin-film element includes a first layer for processing a fluid sample to generate a first analyte and a second analyte. The thin-film element also includes a second layer configured to be impermeable to the first analyte to enable the first analyte to be retained by the first layer and permeable to the second analyte to enable the second analyte to pass through the second layer. The thin-film element further includes a third layer configured to retain the second analyte. The second layer includes a first reflective surface and a second reflective surface to provide reflectance signals indicative of analytes present in the first and third layers to sensors located on opposite sides of the thin-film element.

A handheld occult blood testing device is disclosed. The occult blood testing device includes a hemoglobin sensor, at least one elastic clip and a sleeve. The elastic clip is disposed on the surface of the hemoglobin sensor and the sleeve is sleeved over the hemoglobin sensor, wherein a plurality of through holes are disposed on the surface of the sleeve for the elastic clip to pass through and be exposed from the surface of the sleeve. The sleeve is movable relative to the hemoglobin sensor between a first position and a second position, wherein the sleeve at the first position does not press the elastic clip such that the elastic clips a filter unit to the hemoglobin sensor, and the sleeve at the second position compresses the elastic clip such that the elastic clip releases the filter unit on the hemoglobin sensor.

A sensor according to a first embodiment of the present invention includes a flow channel to permit passage of a specimen, a first detection part that is located in the flow channel and has a first ligand specifically bindable to a first material in the specimen, and a second detection part that is located downstream of the first detection part in the flow channel and has a second ligand specifically bindable to the first material and/or a second material in the specimen.

The present disclosure provided methods and systems for diagnosing diseases and monitoring their progression and therapeutic responses by detecting a presence or absence, or an increase or decrease, of one or more substances in a sample.

An apparatus for determining the mean corpuscular haemoglobin concentration (MCHC) in a whole blood sample, comprising: a sample holder including an elongate sample chamber having an open end and a closed end; a holding member adapted to receive and retain the sample holder, wherein the holding member may rotate about an axis of rotation, and wherein, when the sample holder is received and retained by the holding member the sample chamber is substantially perpendicular to the axis of rotation; first and second light sources positioned on one side of the sample holder, configured to emit light in respective different frequencies; and at least one light sensor positioned on a second side of the sample holder, opposite from the first side, so that light from the light source may pass through the sample chamber, in at least one rotational position of the sample holder, and impinge on the at least one light sensor.