A test sensor for determining an analyte concertation in a biological fluid comprises a strip including a fluid receiving area and port-insertion region. A first row of optically transparent and non-transparent positions forms a calibration code pattern disposed within a first area of the port-insertion region. A second row of optically transparent and non-transparent positions forms a synchronization code pattern disposed within a second area of the port-insertion region. The second area is different from the first area. The synchronization code pattern corresponds to the calibration code pattern such that the synchronization code pattern provides synchronization of the serial calibration code pattern during insertion of the port-insertion region into the receiving port of the analyte meter.

Provided are an amadoriase that is less likely to be influenced by oxygen concentration and a method and a reagent kit for measurement of HbA1c using such amadoriase. Provided are an amadoriase that is obtained via substitution of one or more amino acid residues at a position or positions corresponding to the position(s) selected from the group consisting of positions 280, 267, 269, 54, and 241 of the amadoriase derived from the genus Coniochaeta, a method for measurement of HbA1c, a reagent kit for measurement, and a sensor using such amadoriase. The modified amadoriase according to the invention has a lowered oxidase activity and an enhanced dehydrogenase activity, and this enables the use of an electron mediator, and this reduces the influence of oxygen concentration. Thus, HbA1c can be measured with high sensitivity.

Analyte sensors and methods for fabricating analyte sensors in a roll-to-roll process are provided. In an exemplary embodiment, a method includes providing a roll of a polyester substrate having a first side coated with a layer of platinum, wherein the platinum is in direct contact with the polyester substrate; patterning the layer of platinum to form electrodes; punching the polyester substrate to form ribbons, wherein each ribbon is connected to a remaining polyester substrate web by a tab, and wherein each sensor includes an electrode; after punching the polyester substrate to form ribbons, depositing an enzyme layer over the portions of the working electrodes and coating the working electrodes with a glucose limiting membrane; after depositing the enzyme layer over the portions of the working electrodes and coating the working electrodes with a glucose limiting membrane, singulating the individual sensors by completely separating each individual sensor from the polyester substrate.

The present disclosure provides a system for measuring a property of a sample comprising: a test strip for collecting the sample; a diagnostic measuring device configured to receive the test strip and measure a concentration of an analyte in the sample received on the test strip; and the diagnostic measuring device further comprising a processor programmed to execute an analyte correction for correcting a measurement of the sample due to one or more interferents, comprising: calculating an interferent impedance measurement including a magnitude measurement and a phase measurement using a difference identity to generate a sinusoidal signal with an amplitude proportional to the phase difference; and adjusting the measurement of the analyte in the sample using that the calculated interferent impedance measurement.

Detection of hydrogen peroxide or phosphate related compounds in test or clinical samples by using potentiometric sensors wherein the reference electrode and a hydrogen peroxide selective electrode are both connected by a polyelectrolyte positioned in-between. More particularly a potentiometric sensor device for the detection of chemical species in solution with a novel configuration is disclosed.

Using a biosensor including a flow path into which blood containing a target is introduced, an upstream electrode pair disposed in the flow path and having a reagent reacting with the target disposed on either of the electrodes, and a downstream electrode pair disposed at a downstream side of the flow path; the method includes a first detection step of detecting a first introduction of blood as far as the upstream electrode pair; a second detection step of detecting a second introduction of blood as far as the downstream electrode pair; a time measurement step of measuring a time difference from the first introduction to the second introduction; and a measurement step of acquiring the value related to the target based on the time difference by using any two electrodes among the upstream and downstream electrode pair after the second introduction is detected.

A fluidization measurement system for a gas phase reactor containing a fluidized bed includes a measurement probe coupled to a sidewall of the gas phase reactor. The measurement probe includes a support bar penetrating the sidewall and extending into the fluidized bed to a distance of at least 12% of a diameter of the gas phase reactor, and a plurality of sensors arranged along a length of the support bar to obtain measurements of at least one of temperature, pressure, and electrostatic charge at multiple points within the fluidized bed. A base plant control system is in communication with measurement probe to receive and process the measurements to determine real-time physical conditions and flow patterns of the fluidized bed.

Embodiments of the invention provide methods and materials for making analyte sensors having a plurality of layered elements such as amperometric glucose sensors that are used by diabetic individuals to monitor blood sugar concentrations. Embodiments of the invention utilize plasma deposition technologies to form thin films of hexamethyldisiloxane useful in such sensors. Sensors that incorporate the thin film compositions formed by these processes exhibit a number of desirable characteristics.

A sensor assembly for sensing an analyte in a sample matrix comprises an electrode assembly comprising a set of at least one test electrode and may also comprise one or more control electrodes and/or an applicator assembly. The electrode assembly is configured or configurable to define one or more active test electrodes of the set of one or more test electrodes, and at least one of the electrode assembly and the applicator assembly is or are configured or configurable to adjust a quantity of the analyte provided to the active electrode(s), per unit time, for said interaction based at least in part on an analyte characteristic. Alternatively or additionally, the electrode assembly is configured and arranged in a flow path such that the amounts of sample matrix provided to the test electrode(s) and control electrode(s) of the electrode assembly are substantially equal.

A method of detecting at least one analyte in a test sample is provided comprising a) contacting the test sample (i) to an active chemistry matrix changing at least one electrochemical property dependent on an enzymatic activity active in the presence of the analyte, the active chemistry matrix contacting a first electrode; and (ii) to an inactive chemistry matrix, the inactive chemistry matrix contacting a second electrode, b) closing an electrical circuit including the first electrode, the second electrode, and the active chemistry matrix and inactive chemistry matrix, followed by determining a first value of the at least one electrochemical property, c) inverting electrical polarity of the electrical circuit of b), followed by determining a second value of the at least one electrochemical property, and d) detecting the at least one analyte based on the first value and on the second value.