An injection guide globally aligns an injector to an angle selected for consistent subcutaneous delivery of an injectate, while locally aligning a patient's skin normal to the injection path at the location where the injection pierces the skin. This arrangement advantageously maintains controlled contact between an injector and a subject's skin in order to deliver the full, intended volume of injectate into the patient's subcutaneous layer while avoiding misdelivery into adjacent layers such as the patient's dermis or muscle.

In a needleless syringe according to the present invention, a current is supplied to a solenoid coil to generate a magnetic field so as to move a moving magnetic body and a piston forward, and when the current to the solenoid coil is cut off, an elastic member for the moving magnetic body moves the moving magnetic body backward and an elastic member for the piston moves the piston backward, so that the piston to be injected by pressurizing a drug is configured to reciprocate repeatedly forward and backward and thus, a predetermined drug can be repeatedly injected at high speed. In addition, according to the present invention, time for which the current is applied to the solenoid coil, is adjusted to minimize recoil without adding a recoil offset structure so that the structure is simple and convenience of use can be improved.

Provided are a device whereby, during process of a process target such as a cell or the like, localized process of a process part is possible without inflicting damage due to heat, and rejoining and regeneration may proceed readily subsequent to process, and whereby an injection substance may be introduced efficiently; and a device for generating bubbles containing a plasma. Through the use of a localized ablation device employing a bubble jetting member having a core formed from a conductive material, a shell part formed from an insulating material, covering the core and including a section extending from the tip of the core, and a space formed between the extended section of the shell part and the tip of the core, a process target can be treated in localized fashion and without inflicting damage. By further providing an outside shell part at the outer periphery of the shell part, bubbles onto which a solution containing an injection substance has been adsorbed can be ejected, and the injection substance can be introduced during localized ablation of the process target. Additionally, by including a pair of electrodes formed from a conducting material, for generating a plasma in an inert gas, a liquid flow passage through which a liquid flows, and a microscopic flow passage for flow of an inert gas, an inert gas containing a plasma, and bubbles of inert gas containing a plasma, the liquid flow passage and the microscopic flow passage connecting at the downstream side from a section in which plasma is generated in the microscopic flow passage, bubbles containing a plasma can be generated, and can maintain a plasma state even in liquid, whereby therapy of biological tissue can be effected with the plasma.

An injection nozzle for a needleless injection device includes at least one outlet conduit extending parallel to an injection axis (B). The outlet conduit(s) include a first conduit portion having a first section, a second conduit portion having a second section, the first section being larger than the second section, and a connecting portion between the first conduit portion and the second conduit portion. The connecting portion is inclined at an angle between 70° and 90° with respect to the injection axis (B).

A monitoring device for monitoring a pressure or an injection force of a plurality of jets generated by channels at an outlet of a nozzle of a needleless injection device. The monitoring device includes a plurality of measuring elements. Each measuring element is configured to measure a pressure or an injection force of a corresponding jet of the plurality of jets. Each measuring element includes a receiving face oriented to receive the corresponding jet.

An exemplary embodiment of the present disclosure can provide an injector including a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger member can include a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom and a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram.

A dispensing device for dispensing a beneficial agent configured to transition between an inactive state and an active state. The dispensing device can include a body, a pressure chamber, a primary container, and/or a diaphragm. The pressure chamber and diaphragm may both be disposed within the body, and the primary container may be disposed within the pressure chamber and engaged with the diaphragm. The primary container may include a distal end with a septum or pierceable fitment disposed on a distal side of the diaphragm. The dispensing device may be configured to transition between an inactive state and an active state when a pressurized fluid is provided to the pressure chamber by moving the primary container distally against the diaphragm to cause the diaphragm to deform, including stretching a section of the diaphragm in a distal direction.

A device for the needle-free injection of a fluid into an animal can include a contact device including a shaped contact surface that is shaped in conformity with a body part of the animal to which the injection is to be administered. Also included is a first injector including a front dispensing end which, during the needle-free injection, extends through a first passage opening in the shaped contact surface and protrudes in relation to the shaped contact surface in a region adjacent to the first passage opening, a first measuring device which outputs at least one first measuring signal in order to detect contact of the animal with the front dispensing end of the first injector, and a control unit which activates a needle-free injection via the first injector on the basis of the at least one first measuring signal.

This disclosure relates to dental anesthetic delivery devices and associated methods for using the same. In certain embodiments, an anesthetic delivery device may comprise a pressure-driven needleless injector configured to deliver anesthetic deeply into the gingiva, allowing for a deep numbing and anesthetic effect and reducing pain from subsequent anesthetic injections and/or dental procedures. In some embodiments, the anesthetic delivery device may be T-shaped allowing for a shorter longitude axis length of the syringe body, improved clinician view of the oral cavity during use, single hand and/or ambidextrous use, and/or improved control during positioning.

An apparatus for use in injectate delivery includes an actuator including a linkage, a force generating mechanism mechanically coupled to the linkage, and a controller coupled to the force generating mechanism. The force generating mechanism includes a passive force generator and an active force generator. In operation and on the basis of a control signal, the controller is configured to control the force generating mechanism to provide an input force to the linkage that is a combination of the first force provided by the passive force generator and a second force provided by the active force generator.