A guidewire, methods of manufacture, and methods of use is described. The guidewire may include a core having one or more preformed ribs along a portion thereof. The ribs may form a portion of the outer surface of the guidewire or form a texture or shape of the outer surface of the guidewire. The ribs and outer texture of the guidewire can beneficially help the guidewire remain in a desired location in a body and help prevent or limit migration. Forming the ribs on the outer surface of the core may enable the guidewire to have greater rigidity and stiffness. The core may include a reduced diameter region distal of the ribs. The guidewire may include a cap over the reduced diameter region of the core.

The present disclosure is directed to intravascular devices, systems, and methods having a core member coupled to a shaping ribbon with an adhesive. In some aspects, a sensing guide wire is provided. The sensing guide wire can include a flexible elongate member; and a sensing element coupled to a distal portion of the flexible elongate member, wherein the distal portion of the flexible elongate member includes: a core member; and a shaping ribbon fixedly secured to the core member by an adhesive and at least one connecting sleeve. In other aspects, methods of forming a sensing guide wire are provided.

A guide wire includes an elongated core wire possessing a distal portion at which is located a reshaping portion that is configured to be reshaped. The reshaping portion includes a first material portion made of a first material and a second material portion which is made of a second material different than the first material. The first material portion is joined to the second material portion at a joint surface which extends in the longitudinal direction of the core wire.

Disclosed is a guidewire having a core wire and an outer tube within which the distal section of the core is inserted. The outer diameter of the tube is greater than the outer diameter of the proximal section of the core wire. The guidewire also includes a proximal coil and a distal, radiopaque coil each disposed over the distal section of the core. A bushing coil is disposed over the proximal coil and distal coil. The proximal coil, distal coil, and bushing coil aid in filling the annular space between the core and the tube and thereby centering and aligning the core and tube.

A guidewire formed from drawn filled tubing having an inner core member encased in an outer layer. The inner core member is formed from a linear elastic or superelastic material and the outer layer is formed from a metal alloy such as 35N LT. A portion of the outer layer is ground down to form a feather edged joint between the outer layer and the inner core member.

A guidewire, methods of manufacture, and methods of use is described. The guidewire may include a core having one or more preformed ribs along a portion thereof. The ribs may form a portion of the outer surface of the guidewire or form a texture or shape of the outer surface of the guidewire. The ribs and outer texture of the guidewire can beneficially help the guidewire remain in a desired location in a body and help prevent or limit migration. Forming the ribs on the outer surface of the core may enable the guidewire to have greater rigidity and stiffness. The core may include a reduced diameter region distal of the ribs. The guidewire may include a cap over the reduced diameter region of the core.

A guidewire for intravascular procedures is provided. The guidewire may include a guidewire shaft and a distal end. The guidewire shaft may include a proximal shaft portion that is substantially straight and an intermediate portion integral with or connected to the proximal shaft portion. The intermediate portion may have a meandering shape in at least one first plane. The distal end may be connected to the intermediate portion of the guidewire shaft and have a curved shape in a second plane different from the at least one first plane of the meandering shape of the intermediate portion.

A delivery device to deliver a tubular instrument into a catheter extending distally from a catheter adapter. The delivery device may include a housing configured to couple to the catheter adapter. The delivery device may include a tubular instrument configured to insert through the catheter. The tubular instrument may include a distal end, a proximal end, and a lumen extending between the distal end and the proximal end. The distal end may include a distal tip, which may be closed. The proximal end may be secured within the housing. The tubular instrument may be configured to advance distally with respect to the housing. A portion of the distal end proximate the distal tip may include a first material and maybe stiffer than the distal tip, which may include a second material. A durometer of the first material may be greater than a durometer of the second material.

The present invention relates to the technical field of medical devices, and in particular, to a developable interventional guidewire for hyperpolarized .sup.129Xe MRI and a preparation method thereof. The interventional guidewire includes a guidewire body, a cladding layer wrapped around a surface of the guidewire body, a Zn(II)-PDA modified layer adhered to a surface of the cladding layer, and a developing film layer coated on the Zn(II)-PDA modified layer. The Zn(II)-PDA modified layer is introduced on the guidewire body and, through activation treatment with 2-methylimidazole and solvothermal synthesis, a continuous and dense ZIF-8 film layer is prepared as the developing film layer for the hyperpolarized .sup.129Xe MRI.

Intravascular delivery system for deployment of a therapeutic device (such as a stent, and/or other therapeutic devices including balloon catheter(s), laser catheter(s), intravascular ultrasound (IVUS), Optical coherence tomography (OCT), drug delivery catheter(s), coil delivery catheter(s), etc.) as required by a particular surgical procedure, in a controlled and robust manner is supported by a lockable balloon catheter equipped with a locking mechanism configured to lock in vivo to a delivery component, such as a guidewire. The lockable balloon catheter can be controllably transitioned between locked and unlocked modes of operation by inflation/deflation of the balloon of the lockable balloon catheter. The system provides an enhanced interlocking interface between the delivery component and an inner shaft by a unique configuration of the inner shaft. Connection of the inner shaft/guidewire and/or outer shaft/inflation lumen to the balloon is by an extended neck at the end(s) of the balloon which snuggly envelopes the portions of the inner and/or outer shaft(s) entering/exiting the balloon, thus avoiding the bonding and simplifying fabrication process. Being in the locked mode of operation, the lockable balloon catheter facilitates delivery of the therapeutic device along the delivery component to a target site while enhancing the stability of the delivery component, especially near the target site.