Methods, systems, and devices are disclosed for acquiring and analyzing physiological signals. In one aspect, a physiological sensor device includes a substrate formed of an electrically insulative material and structured to allow physical contact of the device with the frontal region of the head of a user, a recording electrode configured at a first location on the substrate to acquire an electrophysiological signal of the user, a reference electrode configured at a second location on the substrate to acquire a reference signal to the electrophysiological signal, and a ground electrode configured at a third location at least partially between the first and the second locations on the substrate, in which the first location is posterior to the second and third locations, and in which the device is operable when electrically coupled to an electrical circuit to detect physiological signals of the user.

A non-invasive product customization system and a method of customizing a product formulation is provided. Brain activity of a user is detected in response to an input of a product formulation into a brain of the user via a sensory nervous system of the user. A mental state of the user is detected based on the detected brain activity. The product formulation is modified based on the determined mental state of the user. The modified product formulation may be presented to the user in a manner that modulates the mental state of the user.

Methods, devices, and systems are disclosed for producing cognitive and/or sensory profiles. In one aspect, a method to provide a cognitive or sensory assessment of a subject includes selecting a profile category from among a cognitive performance profile, a sensory performance profile, and a cognitive and sensory performance profile, presenting a sequence of stimuli to a subject, the sequence of stimuli based on the selected profile category, acquiring physiological signals of the subject before, during, and after the presenting the sequence of stimuli to produce physiological data, and processing the physiological data to generate an information set including one or more quantitative values associated with the selected profile category.

Systems, devices, and methods described herein relate to multi-sensory presentation devices, including virtual reality (VR) devices, visual display devices, sound devices, haptic devices, and other forms of presentation devices, that are configured to present sensory elements, including visual and/or audio scenes, to a user. In some embodiments, one or more sensors including electroencephalography (EEG) sensors and a photoplethysmography (PPG) sensors, e.g., included in a brain-computer interface, can measure physiological data of a user to monitor a state of the user during the presentation of the visual and/or audio scenes. Such systems, devices, and methods can adapt one or more visual and/or audio scenes based on user physiological data, e.g., to control or manage the state of the user.

Disclosed is a method for constructing a sensory space of an individual, including: the individual performing a sensory evaluation with at least 4 basic stimuli representative of the sense to be studied, the stimuli having an intensity (or power or level) lower than or in the vicinity of the detection threshold of the sense to be studied; recording signals relating to at least one physiological indicator having reacted during the stimuli; extracting physiological parameters from the recorded signals of the at least one physiological indicator; identifying physiological parameters differentiating the physiological responses; constructing a sensory space based on the physiological responses (PRSS) from the identified differentiating physiological parameters by statistical treatment.

Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a first mode where one or more nerve fibers are not stimulated, and during a second mode where the one or more nerve fibers are stimulated. Delivery timing of electrical stimulation may be closed-loop controlled based on current motor cortex activity and the motor cortex activity recorded previously during both the first and second modes.

Technology for the transition of light and sound over long distances, e.g. TV and radio, has revolutionized society. On the contrary, the technology to perceive a smell remotely is in its infancy, and has severe limitations such as latency, residual and infidelity. A system and methods are disclosed to allow smells to be perceived remotely. It is based on the brain waves associated with the olfactory bulb.

A system for delivering sensory stimulation a sensor; a sensory stimulator configured to deliver sensory stimulation to a patient during a sleep session, the sensory stimulation having varying stimulation intensity levels; and a computer system. One or more physical processors being programmed with computer program instructions which, when executed cause the computer system to: determine sleep stage information of the patient based on brain activity information of the patient during the sleep session from the sensor; provide input to the sensory stimulator based on the determined sleep stage information of the patient, the provided input causing the sensory stimulator to deliver the sensory stimulation to the patient; obtain stimulation response information from the patient, the stimulation response information including patient brain response to the delivered sensory stimulation; and determine a range of the stimulation intensity levels within which the patient brain response reaches a threshold.

A system for delivering sensory stimulation a sensor; a sensory stimulator configured to deliver sensory stimulation to a patient during a sleep session, the sensory stimulation having varying stimulation intensity levels; and a computer system. One or more physical processors being programmed with computer program instructions which, when executed cause the computer system to: determine sleep stage information of the patient based on brain activity information of the patient during the sleep session from the sensor; provide input to the sensory stimulator based on the determined sleep stage information of the patient, the provided input causing the sensory stimulator to deliver the sensory stimulation to the patient; obtain stimulation response information from the patient, the stimulation response information including patient brain response to the delivered sensory stimulation; and determine a range of the stimulation intensity levels within which the patient brain response reaches a threshold.

Methods, devices, and systems are disclosed for producing cognitive and/or sensory profiles. In one aspect, a method to provide a cognitive or sensory assessment of a subject includes selecting a profile category from among a cognitive performance profile, a sensory performance profile, and a cognitive and sensory performance profile, presenting a sequence of stimuli to a subject, the sequence of stimuli based on the selected profile category, acquiring physiological signals of the subject before, during, and after the presenting the sequence of stimuli to produce physiological data, and processing the physiological data to generate an information set including one or more quantitative values associated with the selected profile category.