A cosmetic treatment process for a keratin material, including placing the keratin material in contact with at least one cationic polymer with a molecular weight of between 500 and 5,000,000 daltons, and either simultaneously with or consecutively to the placing the keratin material in contact with said cationic polymer, an electric current is applied using at least one electrode for a time that is sufficient to deposit at the surface of the keratin material an effective amount of said cationic polymer.

Methods of administering a gene therapy construct to the eye including injection of the construct into the eye and application of an electric current to enhance penetration of or cellular expression of molecules in ocular tissues. These methods provide effective technique for the intraocular delivery of gene therapy vectors, especially AAV vectors, and nanoparticles.

A light transmitting probe for use in endodontic procedures comprises a light transmitting core and a metallic sheath surrounding said core. The metallic sheath defines a reflective inner surface. The probe further includes a plurality of apertures formed in the sheath, such that light can exit said probe through the apertures.

A wearable electronic therapeutic device has one or more biometric detectors each for detecting one or more biometric parameters. The biometric parameters are dependent on at least one physiological change to a patient in response to a therapeutic treatment. A microprocessor receives the one or more biometric parameters and applies probabilistic analysis to determine if at least one physiological change threshold has been exceeded dependent on the probabilistic analysis of the two or more biometric parameters. An activation circuit activates an action depending on the determined exceeded physiological change. The action that is activated can be applying an elcetroceutical treatment in addition or as an alternative to a pharmaceutical treatment.

An embodiment relates to a transdermal drug delivery system comprising a patch comprising a) a cartridge comprising a drug; b) a bio-sensor and a non bio-sensor; c) an active delivery pad comprising an electrode for delivery of the drug into a tissue via iontophoresis; d) a power source of electrical energy connected to the electrode; e) a microcontroller configured to control a release of the drug wherein the patch is attached to the tissue via an adhesive pad, and optionally top of patch is covered with a sheet; wherein the bio-sensor is configured to detect a physiological parameter; wherein the non bio-sensor is configured with a software to control working of the patch.

Example inventions are directed to reducing hair loss in a target follicle area where the hair loss has occurred. Examples affix a patch externally on a dermis of a user so that the patch extends over the target follicle area of the user, the patch comprising a flexible substrate, a processor directly coupled to the substrate, and electrodes directly coupled to the substrate. Examples activate the patch to initiate a treatment session, the activating comprising generating electrical stimuli via the electrodes that is directed at the target follicle area.

Example inventions are directed to the repairing of a wrinkle area. Example inventions affix a patch externally on a dermis of a user so that the patch extends over the wrinkle area of the user, the patch comprising a flexible substrate, a processor directly coupled to the substrate, and electrodes directly coupled to the substrate. Example inventions activate the patch to initiate a treatment session, the activating comprising generating electrical stimuli via the electrodes that is directed at the wrinkle area.

Multilayer electrodes, electrode systems, and stimulation systems are disclosed. An electrode may include a conductive layer with a unitary tail, a connector disposed on a distal end of the tail, and a nonconductive top layer disposed along a top portion of the conductive layer. An electrode may include a magnetic lead connector socket, or a receptacle formed by a depression in the conductive layer configured to receive a male connector. An electrode system may include a plurality of conductive zones and a plurality of connectors. A stimulation system may include an electronics layer in electrical contact with a conductive layer via a puncture connection, and may provide an iontophoretic treatment followed by a TENS treatment. Other electrodes, systems and methods are also disclosed.

A sinus treatment device and methods of operating the sinus treatment device that include an enhanced conductive tip and at least one return electrode are disclosed.

In order to achieve the above or other aims, according to one aspect of the present disclosure, a skin care device is provided which comprises: a body comprising a grip section for a user to hold, and a head section positioned at the end of the grip section; a plurality of skin-contacting plates positioned at the end of the head section; a plurality of oscillators for providing oscillations to each of the skin-contacting plates; and a control unit which supplies an electrical current to the skin-contacting plates and controls the oscillators, wherein the positive electrode and the negative electrode of the control unit are respectively connected to different skin-contacting plates.