The invention generally relates to systems and methods for targeting of specific tissue(s) of interest in a sino-nasal region of a patient for the treatment of a rhinosinusitis condition. A device of the present invention includes an end effector including one or more flexible printed circuit board (PCB) members for delivering energy to one or more target sites within the sino-nasal cavity of the patient while minimizing or avoiding collateral damage to surrounding or adjacent non-targeted tissue, such as blood vessels, bone, and nontargeted neural tissue.

The invention generally relates to systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition.

The invention generally relates to systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition.

Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

A system comprising (1) a microelectrode array (MEA) component comprising an integrated multiplexed (MUX) logic circuit; and (2) a microprocessor, e.g., MOSFET, such as a CMOS, wherein the MEA is in electrical communication with the microprocessor such that signals produced by the microelectrodes are transmitted to the processor through the MUX. The use of a MUX reduces the number of outputs used to communicate signals from multiple microelectrodes to the microprocessor. The two components are removably engageable with each other such that after one or more uses, the engaged MEA can be removed and replaced with a new MEA, without the necessity of disposing the microprocessor.

The invention generally relates to systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition.

A method for treating nerves in a nasal cavity starts with identifying a patient having a condition occurring outside the nasal cavity. The method then involves activating a console attached to a radiofrequency stylus, advancing a distal tip of the radiofrequency stylus into a nostril of the patient, contacting nasal mucosa lining the nasal cavity with a treatment surface of the distal tip, and delivering radiofrequency energy from one set of bipolar electrodes on the treatment surface of the distal tip to a second set of bipolar electrodes on the treatment surface, to treat at least one nerve underlying the nasal mucosa. Treating the nerve (or nerves) involves modulating activity of the nerve to ameliorate the condition occurring outside the nasal cavity.

The invention generally relates to systems and methods for treating at least one of rhinitis, congestion, and/or rhinorrhea to thereby reduce or eliminate symptoms associated therewith, including, but not limited to, coughing, sneezing, nasal or throat irritation and itching, and difficulty sleeping.

Provided herein is a system comprising (1) a microelectrode array (MEA) component comprising an integrated multiplexed (MUX) logic circuit; and (2) a microprocessor, e.g., MOSFET, such as a CMOS, wherein the MEA is in electrical communication with the microprocessor such that signals produced by the microelectrodes are transmitted to the processor through the MUX. The use of a MUX reduces the number of outputs used to communicate signals from multiple microelectrodes to the microprocessor. The two components are removably engageable with each other such that after one or more uses, the engaged MEA can be removed and replaced with a new MEA, without the necessity of disposing the microprocessor.

One aspect of the present disclosure relates to a system for treating a medical condition in a patient. The system can include a neurostimulator that is in electrical communication with a remote transducer. The neurostimulator can be sized and dimensioned for injection or insertion into a pterygopalatine fossa (PPF) of a patient. The remote transducer, when activated and brought into close proximity to the patient's head, can cause the neurostimulator to deliver an electrical signal to a target neural structure located within the PPF to treat the medical condition.