A system and method for extracting ETI load parametric data relative to one or more electrodes of an implanted stimulation lead system associated with an IPG. A Kelvin connection scheme is provided for measuring induced voltages present at stimulated electrodes during a stimulation ramping sequence, which may be used for determining the ETI parametric data using a number of techniques, including, without limitation, a waveform analysis.

A system may comprise a controller configured to implement an algorithm on a received input to produce an output, and a system input operably connected to the controller and configured for use to enter at least one input into the algorithm. The at least one input may include: one or more sensor inputs or one or more inputs from smart appliances or one or more user inputs regarding at least one of time of day or mental or physical state; or at least one of a user-inputted disease, a user-inputted disease state, or a user-inputted symptom-related information into the algorithm. The controller may be configured to provide instructions through the system output to implement a system action. The algorithm implemented by the controller may be configured to identify one, or a combination of more than one, of the neuromodulation modes as a candidate neuromodulation mode based on the input(s).

A dental treatment apparatus is a dental treatment apparatus that energizes a dental treatment site such as a root canal with a high-frequency current. Included are a holder that holds an electrode placed at the dental treatment site, a power supply that energizes the electrode with the high-frequency current, and control circuitry that causes, during the energization operation, the power supply to provide stop period where the energization of the electrode with the high-frequency current is stopped between single energization period and next single energization period.

Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.

An electrode for neural sensing and stimulation comprising a first electrode disposed on a probe and a second electrode disposed on the probe, wherein a voltage or impedance is sensed using the first electrode and second electrode.

Methods and systems for obtaining and analyzing electromyography responses of electrodes of an implanted neurostimulation lead for use neurostimulation programming are provided herein. System setups for neural localization and/or programming include a clinician programmer coupleable with a temporary or permanent lead implantable in a patient and at least one pair of EMG sensing electrodes minimally invasively positioned on a skin surface or within the patient. The clinician programmer is configured to determine a plurality of recommended electrode configurations based on thresholds and EMG responses of the plurality of electrodes and rank the electrode configuration according to pre-determined criteria. The clinician programmer further includes graphical user interface on which the plurality of recommended electrode configurations are displayed for modification and/or selection by a clinician in programming an IPG or EPG coupled with the lead to apply a neurostimulation treatment according to the selected electrode configuration.

A method and a cochlea implant system for providing reliably control and stability of the ratio between the positive charge and the capacitive discharge of an electrical pulse are disclosed. The system includes an external unit configured to receive acoustical sound and process the acoustical sound into a coded audio signal, and an implantable unit configured to receive the coded audio signal. The system further comprises a pulse generating unit configured to generate a first electrical pulse of a first pulse duration and a second electrical pulse of a second pulse duration different from the first pulse duration based on the coded audio signal. The system still further comprises an electrode array including a plurality of electrodes, wherein at least one of the plurality of electrodes is configured to receive at least the first electrical pulse and the second electrical pulse, and a capacitor connected to the at least one of the plurality of electrodes. The system still further comprises a measurement unit configured to measure, across the connection of the at least one of the plurality of electrodes and the capacitor, a first voltage based on the first electrical pulse and a second voltage based on the second electrical pulse. The system still further comprises an evaluation unit configured to calculate a voltage difference between the measured first and second voltages.

A system for sleep apnea treatment includes an implantable medical device (IMD) coupled to a first lead and a second lead, wherein the IMD comprises a processor and stimulation circuitry, and wherein the processor is configured to cause the stimulation circuitry of IMD to: transmit a first stimulation signal to the first lead to stimulate at least one of an ansa cervicalis, a glossopharyngeal nerve, tensor veli, levator veli, and digastric anterior of a patient, and transmit a second stimulation signal to the second lead to stimulate at least one a hypoglossal nerve or a phrenic nerve of the patient.

This document discusses a computer-implemented method of calibration of an implantable neurostimulation device. The method includes sensing one or more symptoms of a neurological condition of a subject using a sensor external to the neurostimulation device; delivering neurostimulation to the subject using the neurostimulation device and adjusting neurostimulation parameters based on the sensed symptom; sensing one or more neural response signals resulting from the neurostimulation using a sensor of the neurostimulation device; correlating the sensed symptom with the one or more sensed neural response signals; determining a target neural response using the correlating; and recurrently adjusting the neurostimulation parameters according to a comparison of subsequently sensed neural response signals to the target neural response signal.

Many embodiments of the invention provide a neuromodulation system that includes a digital control unit (DCU) that activates a stimulation engine during active stimulation, a current mirror that includes two feedback loops including a first feedback loop with positive feedback (PF) made of an error amplifier A.sub.1 and transistors M.sub.3 and M.sub.1 and a second feedback loop with a negative feedback (NF) made of the error amplifier A.sub.1 and transistor M.sub.3, and a high-voltage adaptive rail (V.sub.dd/V.sub.ss) to accommodate voltage drops across high electrode impedances.