A method of making a denture comprised of fabricating a mold form, including a mold surface corresponding to an external surface of the denture; casting a liquid mold block material against the mold surface of the mold form, and curing the liquid mold block material to form a solid mold block including a second mold surface corresponding to the external surface of the denture. Denture teeth are placed in the tooth sockets of the mold block. Denture base material is delivered against the denture base surface portion of the second mold surface and bases of the denture teeth. The liquid denture base material is cured into a solid state to form a denture base block including embedded denture teeth. The denture base block is placed in a milling fixture; and milled to form the internal surface of the denture.

Provided are a mold for manufacturing a percutaneous absorption sheet that can be detected from an image, and an apparatus and a method for manufacturing a percutaneous absorption sheet having a needle-like protrusion using the mold. The mold is a mold for manufacturing a percutaneous absorption sheet in which a plurality of needle-like recessed portions are disposed, and the problem is solved by a mold for manufacturing a percutaneous absorption sheet in which the mold has a gray color in which a brightness value in a case where a brightness in an HSL (Hue Saturation Lightness) color space is represented in 256 levels is in a range of 30 or more and 200 or less.

Provided is a method for manufacturing a microneedle array in which the distal end of a needle-like recessed portion is reliably filled with a drug solution. The problem is solved by a method for manufacturing a microneedle array, including: a positioning adjustment step of adjusting positioning of a mold having a needle-like recessed portion on a front surface, and a drug solution ejection nozzle which ejects a drug solution; a relative movement step of moving the mold and the drug solution ejection nozzle relative to each other to cause a position of the needle-like recessed portion and a position of the drug solution ejection nozzle to coincide with each other in a plan view in a direction parallel to an ejection direction of the drug solution; an ejection step of ejecting the drug solution from the drug solution ejection nozzle toward the needle-like recessed portion; and a suction step of suctioning a rear surface of the mold.

Provided are a production method of a mold having a recessed pedestal pattern for preventing a liquid flow and a manufacturing method of a pattern sheet. A production method of a mold having a recessed pedestal pattern, has: a step of preparing an insert mold having a protruding needle pattern group; a step of preparing a mold having a first mold provided with a protruding pedestal shape and a second mold; a holding step of holding the protruding pedestal shape of the first mold and the protruding needle pattern group of the insert mold in an overlapping manner; a clamping step of performing clamping with the first mold and the second mold to form a cavity; and an injection step of filling the cavity with a resin.

Methods for mass production of new microfluidic devices are described. The microfluidic devices may include an array of micro-needles with open channels in fluid communication with multiple reservoirs located within a substrate that supports the micro-needles. The micro-needles are configured so as to sufficiently penetrate the skin in order to collect or sample bodily fluids and transfer the fluids to the reservoirs. The micro-needles may also deliver medicaments into or below the skin.

A system for providing a replica masturbation device is disclosed. Users upload images of their body parts to a central database, and other users use data sets generated based on these images from the central database to produce replica masturbation devices of the user's body parts.

The present disclosure provides a preparation method of a splicing imprint template including a first splicing area and a second splicing area adjacent to each other, the preparation method including: forming a first splicing imprint pattern in the first splicing area on a base substrate; forming a sacrificial layer on a side surface of the first splicing imprint pattern facing away from the base substrate; forming a second template glue in the second splicing area on the base substrate; patterning the second template glue in the second splicing area by a preset cavity template; curing and demolding the second template glue; and removing the sacrificial layer through a specific film removing process. The present disclosure further provides a splicing imprint template and a cavity template.

A stamp replication device for producing stamps for the production of at least one of microstructured and nanostructured components has a platform, a cover that is positionable on the platform and a holding device for a stamp carrier, wherein the holding device is provided on the cover or on the platform and includes a carrier as well as a microstructured vacuum surface on the carrier for holding the stamp carrier. In addition, a method for producing a holding device for a stamp replication device as well as a method for producing a stamp are specified.

Provided is a method of producing a transdermal absorption sheet using an electroforming mold. A method of manufacturing an electroforming mold includes preparing a mold which is a matrix having a recessed pattern, immersing the mold in a degassed pretreatment liquid stored in a pretreatment liquid tank, then applying ultrasound waves generated from an ultrasound oscillator to the recessed pattern of the mold, and filling recessed portions constituting the recessed pattern with the pretreatment liquid. By immersing the mold in an electroforming tank and performing an electroforming treatment, an electroforming mold is manufactured. A mold having a recessed pattern is manufactured from the electroforming mold and a transdermal absorption sheet is produced using the mold.

The present invention relates to a method of manufacturing a mold for a diffraction grating light guide plate by using two mask films, the mold having first to fourth pattern portions provided on one surface thereof, and to a method of manufacturing a diffraction grating light guide plate.