Provided are a manufacturing method of a plate precursor having a plurality of needle-like protrusions and a manufacturing method of a microneedle array, which make it possible to manufacture a plate precursor within a short period of time.

A manufacturing method of a plate precursor having a needle-like protrusion includes: a preparation step of preparing a cutting tool including at least one blade conforming to an external shape of the needle-like protrusion, and a base material; and a cutting step of cutting the base material by rotating the cutting tool about a tool axis of the cutting tool and revolving the cutting tool around an axis of the needle-like protrusion to be formed on the base material to form the needle-like protrusion having a shape conforming to a shape of the cutting tool.

Simulated anatomical components, such as simulated vascular vessels, produced by a method that includes forming an anatomical component mold from a soluble polymer such that the mold defines an interior void of the simulated anatomical component. One or more layers of an elastomeric material is applied around the anatomical component mold and the material is allowed to cure to form a wall of the simulated anatomical component. At least a portion of the mold is dissolved to form a passage for liquid within the simulated anatomical component. Simulated anatomical components are connectable to other components of a surgical simulation system and can be modularized.

Simulated anatomical components, such as simulated vascular vessels, produced by a method that includes forming an anatomical component mold from a soluble polymer such that the mold defines an interior void of the simulated anatomical component. One or more layers of an elastomeric material is applied around the anatomical component mold and the material is allowed to cure to form a wall of the simulated anatomical component. At least a portion of the mold is dissolved to form a passage for liquid within the simulated anatomical component. Simulated anatomical components are connectable to other components of a surgical simulation system and can be modularized.

A method is for producing a profile segment of a segmented casting-vulcanizing mold for vehicle tires, the molding area of which molds a segment of the tread profile of a tire to be vulcanized, including the steps: creating a rigid model segment having a casing-like tread surface; milling the profile positive of the tread into the casing-like tread surface of the model segment to obtain the master model; creating a flexible impression from the master model; creating a rigid plaster cast from the impression to form a casting core segment; casting all of the annular, placed-together casting core segments with an aluminium-magnesium alloy to obtain a vulcanizing mold, subsequently divided into profile segments. A plasma coating is applied to the tread of the model segment, into which the profile positive of the tread is subsequently milled to obtain the master model. Plasma coating gives the master model a defined roughness.

A system (200) for making a fitted cap (300) comprises a fastener template (202), dimensionally identical to a portion (106) of a fastener (100) and extending from a support plate (210), and a first plurality of through-openings (212) penetrating the support plate (210) and arranged about the fastener template (202). The system (200) also comprises a precursor cap (320) that is geometrically complementary to the fastener template (202), first means (217) for heating a first polymer sheet (270), and second means (219) for applying suction to the first polymer sheet (270) through the first plurality of through-openings (212) to vacuum-form the first polymer sheet (270) over the precursor cap (320). After vacuum-forming the first polymer sheet (270) over the precursor cap (320), at least a portion of the first polymer sheet (270) forms the fitted cap (300). The fitted cap (300) is configured to apply a shaped sealant shroud (590) to the portion (106) of the fastener (100).

The present invention relates to a method of manufacturing a metal mold for replicating a component having a predetermined three-dimensional shape, the manufacturing method comprising: (a) fabricating a glass-based mold by using a moldable nanocomposite comprising an organic binder and glass particles dispersed therein, the glass-based mold having the predetermined three-dimensional shape; and (b) replicating the glass-based mold obtained in step (a) by melting a metal inside the glass-based mold or by melting a metal outside the glass-based mold and pouring it onto or into the glass-based mold, followed by cooling, or by pressing the glass-based mold into a malleable metal substrate, thereby obtaining the metal mold for replicating the component, the metal mold having the predetermined three-dimensional shape inverted. Further, the present invention relates to a method of replicating a component having a predetermined three-dimensional shape, wherein the metal mold obtained by the manufacturing method is used for replicating the component, wherein the glass particles of the moldable nanocomposite comprise a first type of glass particles having a diameter in the range from 5 nm to 500 nm.

A system (200) for making a fitted cap (300) comprises a fastener template (202), dimensionally identical to a portion (106) of a fastener (100) and extending from a support plate (210), and a first plurality of through-openings (212) penetrating the support plate (210) and arranged about the fastener template (202). The system (200) also comprises a precursor cap (320) that is geometrically complementary to the fastener template (202), first means (217) for heating a first polymer sheet (270), and second means (219) for applying suction to the first polymer sheet (270) through the first plurality of through-openings (212) to vacuum-form the first polymer sheet (270) over the precursor cap (320). After vacuum-forming the first polymer sheet (270) over the precursor cap (320), at least a portion of the first polymer sheet (270) forms the fitted cap (300). The fitted cap (300) is configured to apply a shaped sealant shroud (590) to the portion (106) of the fastener (100).

Die (1) representing a tread pattern model for a tread of a tire to be molded. The die is made up of a plurality of blocks (2) separated by grooves (4), at least a part of the die having surfaces provided with textures (5).

Die (1) representing a tread pattern model for a tread of a tire to be molded, said die being made up of a die body (2) and at least one insert (10) attached to the body of said die, covering at least one of the surfaces of the grooves (4) in the body (2), the insert having at least one substantially flat surface provided with textures.

The present invention relates to a method of manufacturing a dental component, in particular a dental prosthesis or a partial dental prosthesis, by means of a dental furnace, comprising the following steps: (i) producing a model of the dental component; (ii) embedding the model in an investment material; (iii) removing the model from the investment material, in particular by heating or burning out, to obtain a negative mold of the model; (iv) inserting a raw material required for manufacturing the dental component into the negative mold; (v) producing the dental component in the negative mold; and (vi) deflasking the dental component in an at least partly automated manner, in particular by means of a stripping manufacturing process, on the basis of a virtual model of the dental component.