A device for measuring the turbidity of cerebrospinal fluid includes, a source of a light signal comprising having one or more wavelength(s), such that at least part of the emitted light signal passes through the cerebrospinal fluid; a flow element including an inlet and an outlet, the flow element being suitable for allowing cerebrospinal fluid to flow between the inlet and the outlet; an opaque element, arranged to absorb at least part of the emitted light signal after it has passed through the cerebrospinal fluid, and to allow another part of the emitted light signal to be reflected after it has passed through the cerebrospinal fluid; and an optical detector configured to detect the light signal after it has passed through the cerebrospinal fluid.

A number of variations may include a sterile kit that may include a tray constructed and arranged to hold the necessary items to access an Ommaya reservoir and the tray may define a plurality of other resources or indentations constructed and arranged to seat, hold, or house additional components of the sterile kit. The sterile kit may additionally include a paper towel, a fenestrated drape, a plurality of sponge applicators, at least one pouch of povidone-iodine, at least one retractable winged butterfly needle, at least one luer lock syringe, a 3-way stopcock, a plurality of collection vials with tops which may be screwed on to prevent the contents thereof from leaking or escaping, sterile pads, bandages including adhesive bandages, and other components.

Cerebrospinal fluid (CSF) drainage systems. A system includes a conduit having a proximal end and a distal end. The conduit receives the CSF from a patient from the proximal end. The system includes a collection chamber coupled to the distal end. The collection chamber collects the CSF. The system includes a valve positioned on the conduit. The valve controls CSF flow into the collection chamber. The system includes a camera that captures an image of the CSF within the collection chamber. The system includes a processor coupled to the camera. The processor measures a flow rate of the CSF based on the image and controls the first valve to open for a first predetermined period and close for a second predetermined period until a determination of a predetermined amount of the CSF being drained from the patient is made by the processor based on the flow rate.

In some embodiments, a device may include an intraventricular access device and an infusion device. The intraventricular access device may include more than one catheter and a container. In some embodiments, the catheter may include an aspiration lumen and an infusion lumen. A distal end of the intraventricular portion of the catheter may be positionable, during use, in a subject's brain fluid. In some embodiments, the container may be coupled to a proximal end of the aspiration lumen. The proximal end of the aspiration lumen may be in fluid communication with the container. In some embodiments, the container may include a barrier positioned between a proximal opening of the aspiration lumen and at least a portion of the infusion lumen adjacent to and/or associated with the container. The barrier may inhibit penetration of a surgical instrument.

In some embodiments, a device may include an intraventricular access device and an infusion device. The intraventricular access device may include more than one catheter and a container. In some embodiments, the catheter may include an aspiration lumen and an infusion lumen. A distal end of the intraventricular portion of the catheter may be positionable, during use, in a subject's brain fluid. In some embodiments, the container may be coupled to a proximal end of the aspiration lumen. The proximal end of the aspiration lumen may be in fluid communication with the container. The proximal end of the infusion lumen may be in communication with an infusion pump. In some embodiments, the device inhibits cross contamination between a first fluid in the aspiration lumen and a second fluid in the infusion lumen. In some embodiments, the container may include a barrier positioned between a proximal opening of the aspiration lumen and at least a portion of the infusion lumen adjacent to and/or associated with the container. The barrier may inhibit penetration of a surgical instrument.

An implantable cranial medical device includes a first fluid flow path, a second fluid flow path, and upper flange portion, and a lower portion. The upper flange portion is configured to rest on a skull of a subject about a burr hole. The lower portion is configured to be placed within the burr hole. The first fluid flow path may extend from a first opening in the upper flange portion to a first opening in the lower portion. The second fluid flow path may extend from a second opening in the upper flange portion to a second opening in the lower portion.

A detection system can include a device, a circuit, and at least one indicator. The device can include polymer needle having a distal end and a proximal end. A needle lumen can be extended along a longitudinal axis of the polymer needle. The distal end can include an insertion tip. An elongate sleeve can include a first end and a second end. The polymer needle can be located within an inner bore of the elongate sleeve. The insertion tip of the polymer needle can be disposed at a distance from the elongate sleeve. A first electrode can be coupled to the device and a second electrode can be electrically isolated from the first electrode. The circuit can be configured to provide a signal based on an electrical characteristic between the first electrode and the second electrode. At least one indicator can be communicatively coupled to the circuit and configured to provide an output based on the signal.

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir.

A bio paracentesis needle includes a tube-shaped body having a hollow portion through which a suture is inserted, an insertion portion formed at an end of the body to cut skin and insert the body, and at least one removal cut to an inside of the body to remove waste under the skin when the body is inserted. The insertion portion includes a first inclined edge having a diagonal surface inclined downward in a direction from a first end of the both to the hollow portion, a second inclined edge having a diagonal surface inclined upward from a second end of the body to the first inclined edge, the second end being positioned opposite the first end, and a third inclined edge has a diagonal surface inclined downward in a direction from an end of the first inclined edge to the second inclined edge.

Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.