In some aspects, an apparatus for a biosensor includes a sensor wire and a rigid member. The rigid member may be coupled to the sensor wire and include a contact surface. The contact surface may be sized to enable a suction head of a robotic placement device to create a vacuum seal on the contact surface for lifting the sensor wire and rigid member.

A cannula sensing system and method include a cannula having at least one biosensor configured to detect a level of one or more biomarkers in blood within a blood vessel of a patient. The biosensors are arranged at or near a distal end of a cannula inserted within the blood vessel. The biosensor may be connected to a wire arranged on and/or within a wall of the cannula.

Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

Disclosed are devices, systems and methods for in vivo monitoring of localized environment conditions within a patient user by measuring analytes, including glucose, oxygen, and/or other analytes. In some aspects, a sensor device includes a wafer-based substrate, at least one electrochemical sensor two-electrode contingent including a working electrode and a reference electrode on the substrate and configured to detect a target analyte in a body fluid when the sensor device is deployed within a subject's body, where the working electrode is functionalized by a chemical layer configured to facilitate a reaction involving the target analyte that produces an electrical signal; and an electronics unit in communication with the electrochemical sensor electrode contingent to transmit the electrical signal to an external processor.

A probe for real-time sensing of a target biomarker the includes a needle, a luminescent probe within the opening of the needle, a coating comprising a biomarker luminescent material in contact with biological tissue, and an ion-consuming coating within the needle and adjacent to the coating. The disclosed probe is useful for real-time sensing of blood during medical procedures. Additionally, a biomarker detection system is disclosed that includes a biomarker luminescent material at the tip of or inside of the tip of a needle and an optical coupler.

A proto-microelectrode, a proto-microelectrode bundle and array, a method of manufacture of the proto-microelectrode, and a method of using the proto-microelectrode, the proto-microelectrode being capable of forming a microelectrode upon implantation into soft tissue, and includes an oblong electrode body; an optional first coat of electrically non-conducting material on the electrode body; a second coat of water insoluble flexible polymer material enclosing, at a distance, the electrode body and the first coat, the second coat including one or more through openings; a first layer of ice disposed between the electrode body and the second coat.

An analyte sensor and methods and systems related thereto, where at least one or more of a lower portion of a sensor tail substrate, at least one electrode, a sensing element, a membrane, and an optional non-electrochemical functional layer comprise an antimicrobial quality. Asymmetric, double-sided adhesive binders suitable for adhering the analyte sensor to a skin surface comprising a non-woven scrim, a first pressure-sensitive adhesive layer, a second pressure-sensitive adhesive layer. Overbandages comprising a vapor-permeable backing, an aperture to circumferentially surround a sensor housing, a contact adhesive layer, first and second peelable release liners, and a third peelable release liner disposed upon an anchoring adhesive strip of the contact adhesive layer.

A system is provided for monitoring analyte in a host, including a continuous analyte sensor that produces a data stream indicative of a host's analyte concentration and a device that receives and records data from the data stream from the continuous analyte sensor. In one embodiment, the device includes a single point analyte monitor, from which it obtains an analyte value, and is configured to display only single point analyte measurement values, and not any analyte measurement values associated with data received from the continuous analyte sensor. Instead, data received from the continuous analyte sensor is used to provide alarms to the user when the analyte concentration and/or the rate of change of analyte concentration, as measured by the continuous analyte sensor, is above or below a predetermined range. Data received from the continuous analyte sensor may also be used to prompt the diabetic or caregiver to take certain actions, such as to perform another single point blood glucose measurement. In another embodiment, the device provides for toggling between two modes, with one mode that allows for display of glucose concentration values associated with the continuous glucose sensor and a second mode that prevents the display of glucose concentration values associated with the continuous glucose sensor.

Medical devices and methods thereof for determining bacterial infections in blood. The medical devices and methods thereof can utilize a coating including an antibody conjugated to a reporter protein configured to indicate a bacterial infection in a patient's blood by way of an antigen thereof. Exemplary medical devices include, but are not limited to, a catheter assembly, an AV fistula needle set, an extension set for either a catheter assembly or an AV fistula needle set, and a hemodialysis tubing set. The medical devices and methods thereof can utilize immunochromatographic separation of the antibody and an antigen-antibody complex to indicate a bacterial infection in a patient's blood.

The present invention provides a sensing structure of a micro biosensor for performing a measurement of a physiological parameter of a target analyte of a biofluid and reducing an interference of an interferant of the biofluid on the measurement by an electrochemical reaction. The sensing structure includes: a substrate having a surface; a first working electrode configured on the surface, and including an active surface; at least one second working electrode configured on the surface and adjacent to the first working electrode, for consuming the interferant by the electrochemical reaction; and an isolated layer configured with respect to the active surface to program a diffusive distribution of the interferant when the biofluid flows through the second working electrode, wherein at least the interferant of the biofluid passes through the second working electrode over a time period and is consumed by the second working electrode by the electrochemical reaction.