The present invention provides nutritional compositions that are employed as oral supplementation to the human diet and methods for using such nutritional compositions. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer. Methods are provided that utilize specific combinations of selected forms selenium. chromium, and molybdenum in combination with fish oil.

The present invention provides nutritional compositions that are employed as oral supplementation to the human diet and methods for using such nutritional compositions. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer. Methods are provided that utilize specific combinations of selected forms selenium. chromium, and molybdenum in combination with fish oil.

Disclosed herein are prenatal dosage forms formulated for different stages of the pregnancy cycle. Also disclosed are methods of administering prenatal dosage forms to a prenatal, pregnant or lactating woman. Further disclosed are kits including prenatal dosage forms.

The invention relates to a method for producing, amongst other things, amino-acid and/or hydroxycarboxylic-acid metal chelates, a solvent-free mixture of at least one metal oxide, metal hydroxide, metal carbonate or oxalate, and the solid organic acid is subjected to intensive mechanical stress. According to the invention, this is done in that the reaction partners are introduced in particle form into a fluid stream of a fluid-bed countercurrent mill operating without grinding elements, wherein mechanical activation of at least one of the reaction partners is effected by collision processes within a reaction chamber formed in a region of the fluid stream, and a solid body reaction to form the metal chelate is triggered. The novel method operates very energy-efficiently and with a high specific yield. It leads to a product having compact particles in the small, single-digit micrometer range having a comparatively narrow particle size distribution and a large surface. The product is homogenous and very pure. Thermal loading or decomposition of the organic chelate ligands, in particular of the amino acids, is likewise avoided, as are contaminants from milling and grinding element abrasion.

Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.

The present invention relates to a composition for use in preventing migration of cancer cells in a subject known or suspected to suffer from cancer, the composition comprising at least one metal complex having the structure (I), formula (I), wherein M is a metal, preferably selected from the group consisting of copper, iron, manganese and zinc, X is X.sup.a or X.sup.b, wherein X.sup.a is selected from the group consisting of O, S and —N(R.sup.1)—, wherein R.sup.1 is H or alkyl, and wherein X.sup.b is a group forming a coordinate covalent bond to a second metal M′, preferably a group O, S or —N(R.sup.1)—, wherein M′ is preferably selected from the group consisting of copper, iron, manganese and zinc, and wherein M′ and M may be the same or different and are preferably the same, Z.sup.1 and Z.sup.2 are independently of each other a, substituted or unsubstituted, -Aryl-O—, -Aryl-N— or heteroaryl group, Y is Y.sup.a or Y.sup.b, wherein Y.sup.a is selected from the group consisting of H, alkyl, —OH, —SH, halogen, and —NR.sup.3R.sup.4, wherein R.sup.3 and R.sup.4, are independently of each other selected from H and alkyl, preferably R.sup.3 and R.sup.4 are both H, and wherein Y.sup.b is a group forming a coordinate covalent bond to M or M′, preferably Y.sup.b is a group O, S or —N(R.sup.Yb1R.sup.Yb2), wherein R.sup.Yb1 and R.sup.Yb1, are, independently of each other, H or alkyl, preferably H, and wherein n and m are integers, which are independently of each other, 0 or 1, Y.sup.2 is water or a halogen, and wherein Y.sup.3 is water or a halogen. The present invention further relates to a combined preparation comprising the aforesaid composition as well as to an in vitro method, for determining whether cancer cells are susceptible to immobilizing by the aforesaid compound.

##STR00001##

The present invention relates to a composition for use in preventing migration of cancer cells in a subject known or suspected to suffer from cancer, the composition comprising at least one metal complex having the structure (I), formula (I), wherein M is a metal, preferably selected from the group consisting of copper, iron, manganese and zinc, X is X.sup.a or X.sup.b, wherein X.sup.a is selected from the group consisting of O, S and —N(R.sup.1)—, wherein R.sup.1 is H or alkyl, and wherein X.sup.b is a group forming a coordinate covalent bond to a second metal M′, preferably a group O, S or —N(R.sup.1)—, wherein M′ is preferably selected from the group consisting of copper, iron, manganese and zinc, and wherein M′ and M may be the same or different and are preferably the same, Z.sup.1 and Z.sup.2 are independently of each other a, substituted or unsubstituted, -Aryl-O—, -Aryl-N— or heteroaryl group, Y is Y.sup.a or Y.sup.b, wherein Y.sup.a is selected from the group consisting of H, alkyl, —OH, —SH, halogen, and —NR.sup.3R.sup.4, wherein R.sup.3 and R.sup.4, are independently of each other selected from H and alkyl, preferably R.sup.3 and R.sup.4 are both H, and wherein Y.sup.b is a group forming a coordinate covalent bond to M or M′, preferably Y.sup.b is a group O, S or —N(R.sup.Yb1R.sup.Yb2), wherein R.sup.Yb1 and R.sup.Yb1, are, independently of each other, H or alkyl, preferably H, and wherein n and m are integers, which are independently of each other, 0 or 1, Y.sup.2 is water or a halogen, and wherein Y.sup.3 is water or a halogen. The present invention further relates to a combined preparation comprising the aforesaid composition as well as to an in vitro method, for determining whether cancer cells are susceptible to immobilizing by the aforesaid compound.

##STR00001##

Combined multistage microbial preparations for enhancement of the biological skin barrier and maintenance of healthy skin microbiota are disclosed. The preparations are useful in chronic problems associated with dysbiosis such as atopic dermatitis, acne, rosacea and vitiligo or acute problems caused by damage of the skin such as burns, cuts and contusions.

Combined multistage microbial preparations for enhancement of the biological skin barrier and maintenance of healthy skin microbiota are disclosed. The preparations are useful in chronic problems associated with dysbiosis such as atopic dermatitis, acne, rosacea and vitiligo or acute problems caused by damage of the skin such as burns, cuts and contusions.

Compositions and methods for increasing stress response and improving health and slowing the aging process in a user. A composition includes one or more of a first group consisting of milk thistle, ashwagandha, green tea, bacopa monnieri, and turmeric. The composition includes one or more of a second group consisting of acetyl-L-carnitine, quercetin, lipoic acid, coenzyme Q10, cysteine, and grape. The composition includes one or more of a third group consisting of wasabi, theacrine, copper, nicacin, cysteine, and olive extract.