Disclosed herein is an apparatus for imaging nano magnetic particles using a 3D array of small magnets. A field-free region generation apparatus includes a hexahedral housing having an opening formed in the first surface thereof such that a measurement head is inserted into a spacing area, a pair of rectangular-shaped magnets installed respectively on two surfaces facing each other, among four surfaces perpendicular to the first surface of the housing, and a pair of magnet arrays installed respectively on the first surface of the housing and on another surface facing the first surface, each of the magnet arrays including multiple small magnets arranged along the edge of the opening.

A targetable nanoconstruct capable of simultaneously serving as a therapeutic platform for photodynamic therapy as well as an MR molecular imaging agent, free of heavy metal atoms. F3-cys targeting agent nanoconstructs, including 8PEGA-Ce6 NCs. A label-free 8PEGA nanoconstruct that can be directly and selectively imaged by MRI, using standard spin-echo imaging sequences with large diffusion magnetic field gradients to suppress the water signal.

Described herein are particles comprising a crystalline matrix and a dopant, wherein one of the atoms of the matrix is .sup.19F and .sup.31P, or .sup.13C, .sup.15N, .sup.29Si, .sup.16O, .sup.17O, .sup.23Na, .sup.39K, .sup.25Mg, .sup.40Ca, .sup.43Ca or deuterium; and the dopant is a compound involved in a biological process in a mammalian organism; and wherein the dopant is present in an amount of between 0.01% and 20% of the plurality of particles, and wherein when the matrix comprises an atom selected from the group of .sup.13C, .sup.15N, .sup.29Si, .sup.16O, .sup.17O, .sup.23Na, .sup.39K, .sup.25Mg, .sup.40Ca, .sup.43Ca and deuterium, and the dopant is isotopically enriched.

A method for directing therapeutic nanoparticle-labeled cells to selected locations within the body and/or for retaining therapeutic nanoparticle-labeled cells at selected locations within the body, the method comprising: providing an article comprising a body of material configured to be secured about the body of a patient and having a plurality of pockets thereon, wherein each pocket is sized to receive and retain one or more magnets therein; injecting therapeutic USPIO nanoparticle-containing cells into a target therapy site; securing the article to the body of the patient; and inserting at least one magnet into at least one pocket so as to provide a desired magnetic field for further directing therapeutic nanoparticle-labelled cells to a target therapy site and/or for retaining therapeutic nanoparticle-labeled cells at the target therapy site.

Ferritin or iron-based image enhancement agents identify target tissue for treatment or ablation and are heated by microwave absorption. Microwave heat substrates enhance microwave hyperthermal ablation treatment, and may be percutaneously delivered and imaged by x-ray CT during placement of the microwave treatment antenna, allowing more precise positioning and more complete ablation of a tumor site. One method of treating a target tissue uses image-guided delivery of a heat substrate with a reverse-phase change polymer, and may apply energy to fix a mass of the material in the tissue. The fixed polymer may increase hyperthermia, form a thermal boundary, or blockade a vessel or passage so as to reduce or prevent undesired conductive cooling by contiguous tissue, or may deliver a localized treatment drug at the site, upon heating or as it degrades over time.

The present disclosure provides HRG-Mn.sub.3O.sub.4 hybrid nanoparticles. The HRG-Mn.sub.3O.sub.4 hybrid nanoparticles do not pose any cytotoxicity at normal physiological conditions and therefore they are nontoxic and biocompatible at physiological conditions. The HRG-Mn.sub.3O.sub.4 hybrid nanoparticles under exposure of laser light cause massive cellular damage indicating their potential use for photodynamic therapy of cancer. The HRG-Mn.sub.3O.sub.4 hybrid nanoparticles enhance the magnetic resonance signals from cancer cells and exhibit excellent MRI contrast property for tumor imaging and are therefore useful contrast agent.

A method and apparatus generate electrical currents and/or voltage in tissue using particles composed of liquid crystals and magnetic particles.

This invention provides methods and systems for achieving high-specificity killing of targeted cells using Magneto-Electric Nano-Particles (MENPs) and functional or diagnostic imaging that detects changes at the cellular level. Embodiments comprise injecting into a patient's body manufactured MENPs that have a higher tendency to accumulate near or attach to targeted cells through one or more physical forces and/or biological mechanisms; and applying a magnetic field to the MENPs to generate an action that is sufficient to cause death of the targeted cells, and using an imaging apparatus to image or detect a specific property of the MENPs or changes in a property of the MENPs due to the coupling of the MENPs with their surrounding environment.

A method for directing therapeutic nanoparticle-labeled cells to selected locations within the body and/or for retaining therapeutic nanoparticle-labeled cells at selected locations within the body, the method comprising: providing an article comprising a body of material configured to be secured about the body of a patient and having a plurality of pockets thereon, wherein each pocket is sized to receive and retain one or more magnets therein; injecting therapeutic USPIO nanoparticle-containing cells into a target therapy site; securing the article to the body of the patient; and inserting at least one magnet into at least one pocket so as to provide a desired magnetic field for further directing therapeutic nanoparticle-labelled cells to a target therapy site and/or for retaining therapeutic nanoparticle-labeled cells at the target therapy site.

Ferritin or iron-based image enhancement agents identify target tissue for treatment or ablation and are heated by microwave absorption. Microwave heat substrates enhance microwave hyperthermal ablation treatment, and may be percutaneously delivered and imaged by x-ray CT during placement of the microwave treatment antenna, allowing more precise positioning and more complete ablation of a tumor site. One method of treating a target tissue uses image-guided delivery of a heat substrate with a reverse-phase change polymer, and may apply energy to fix a mass of the material in the tissue. The fixed polymer may increase hyperthermia, form a thermal boundary, or blockade a vessel or passage so as to reduce or prevent undesired conductive cooling by contiguous tissue, or may deliver a localized treatment drug at the site, upon heating or as it degrades over time.