A marker for imaging includes a bio-dissolvable material and a contrast agent configured to provide contrast during an imaging procedure. A method can include forming a marker for imaging from a bio-dissolvable material and impregnating the bio-dissolvable material with a contrast agent. A method can include implanting a bio-dissolvable marker for imaging into a patient.

A uniform cluster of nanocompositions suspended in a liquid media is provided. Methods of making such nanocompositions, and uses of such nanocompositions are also provided. The nanocompositions can be used for nucleic acid extraction and diagnostic assays, for immunoassays, for cell separation, identification and modulation, for controlled functional molecule protection and release, for assays used in the clinic (companion diagnostics) or in the therapeutic development process (drug target validation), and in a system for transcatheter arterial chemoembolization, and demonstrate superior performance due to the uniform property or monodispersity.

Nanoparticles described as metal-encapsulated carbonaceous dots or M@C-dots are disclosed. Also disclosed are specific M@C-dots with gadolinium, so called Gd@C-dots. These nanoparticles are biologically inert and preclude the release of metal in biological environments. In addition, despite a dimension exceeding the commonly recognized threshold for renal clearance, the disclosed nanoparticles can be efficiently cleared via urine after systematic injection. Methods of making and using such nanoparticles are also disclosed.

Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanoparticles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided.
5≦100*D.sub.μ(IO)/C.sub.ω(IO)  [Relation 1]
2.5≦100*D.sub.μ(Cap)/C.sub.ω(Cap)  [Relation 2]
0.5 wt %≦F(IO)≦50 wt %  [Relation 3]
1 nm≦D.sub.μ(IO)≦25 nm  [Relation 4]
50 nm≦D.sub.μ(Cap)≦200 nm  [Relation 5]

A marker for imaging includes a bio-dissolvable material and a contrast agent configured to provide contrast during an imaging procedure. A method can include forming a marker for imaging from a bio-dissolvable material and impregnating the bio-dissolvable material with a contrast agent. A method can include implanting a bio-dissolvable marker for imaging into a patient.

The present disclosure is directed to methods of Quantum Spin Engineering of spinel superparamagnetic ferrite nanoparticles (SMFNs) for MRI contrast agents and for magnetohyperthermia agents. Using the methods herein, the magnetic properties of the SMFNs can be controlled by changing the amount of 3d-transition element cations having unpaired electrons in the 3d orbital that occupy the octahedral sites of the spinel crystal form, to form mixed spinels, while anions in the spinels can be utilized to magnetically couple the cations utilizing intra-crystalline angles determined by ion sizes and crystal structure, and further tuning of other critical parameters is provided. The mixed spinels disclosed herein provide enhanced MRI contrast agents and improved magnetohyperthermia agents with lower toxicity and safety concerns, while the production methods disclosed herein have lower cost.

A non-pyrogenic preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications. The nanoparticles are constituted by a crystallized mineral central part including predominantly an iron oxide, as well as a surrounding coating without material from the magnetotactic bacteria.

The present invention relates to a photosensitizer-containing nanoparticle, comprising a photosensitizer covalently bonded throughout at least a part of said nanoparticle to the nanoparticle matrix material and incorporated therein in a quasi-aggregated state. The present invention further relates to methods for producing the invention nanoparticles, and to methods of killing cancer cells by PDT treatment using the said nanoparticles.

Superparamagnetic nanocomposites are provided. In an embodiment, a superparamagnetic nanocomposite comprises a superparamagnetic core comprising a first, soft superparamagnetic ferrite and a superparamagnetic shell comprising a second, soft superparamagnetic ferrite, the shell formed over the core, wherein the first and second soft superparamagnetic ferrites are different compounds and have different magnetocrystalline anisotropies.

A non-pyrogenic preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications. The nanoparticles are constituted by a crystallized mineral central part including predominantly an iron oxide, as well as a surrounding coating without material from the magnetotactic bacteria.