Patent classifications
A61K9/0043
Antimicrobial Composition
A composition comprising a hydrogen peroxide source and at least one salicylate. Preferably, the hydrogen peroxide source comprises hydrogen peroxide and a means for generating hydrogen peroxide.
METHOD, APPARATUS AND KIT FOR TREATING CHRONIC AND LONG-TERM NASAL CONGESTION
A method of treating episodic and chronic nasal congestion of the human nasal passages is disclosed. The present invention combines use of decongestant nasal spray, saline nasal spray, and nasal dilator therapies with minimized risk of incurring rebound congestion. The method may be used as both preventative and withdrawal therapies for patients experiencing rebound congestion. Nasal dilators, decongestant nasal spray and saline nasal spray are provided in kit form whereby users may practice the method.
Cyclic peptides, cyclic peptide conjugates and methods of use thereof
Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and/or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest.
Nasal foam via cribriform plate for medication delivery to the brain and/or body and for nasal moisturization and hygiene
Methods and compositions for delivering medicine and other substances to the brain and the body via the cribriform plate using foamable compositions are described. Methods and compositions for improving nasal hygiene and moisturizing the nasal cavity using foamable compositions are also described.
Composition for use in the prevention and/or treatment of epistaxis
A synergistic composition of naturally occurring active ingredients is described, which has proved particularly effective in the treatment and/or prevention of epistaxis, particularly in acute or chronic episodes of infectious and inflammatory epistaxis. The composition includes the synergistic combination of hyaluronic acid or a salt thereof, silver, vitamin B5 or pro-vitamin B5, and optionally vitamin E or an ester thereof.
PHOSPHATE DERIVATIVES OF RORGAMMA MODULATORS AND USES THEREOF
The present invention relates to phosphate derivatives of formula (I), and their therapeutic uses, preferably for treating a respiratory disease. The present invention further relates to pharmaceutical compositions and devices comprising such compounds.
METHOD OF PROTECTING A RESPIRATORY TRACT OR A LUNG FROM DAMAGE, METHOD OF PROTECTING A LUNG FROM PRESSURE DAMAGE INDUCED BY A VENTILATOR, METHOD OF SUPPRESSING SPREAD OF INFECTION WITH VIRUSES OR BACTERIA THAT CAUSE PNEUMONIA IN PULMONARY BRONCHIAL EPITHELIAL CELLS OR ALVEOLAR EPITHELIAL CELLS, AND NASAL SPRAY
A method of protecting a respiratory tract or a lung from damage is provided. The method comprises administering a pharmaceutical composition to a patient in need thereof. The pharmaceutical composition comprises trehalose or a trehalose derivative.
Method and apparatus for using iodinated polymer as an antimicrobial agent to manage the suppression and disinfection of pathogens
Disclosed is a method and apparatus for using iodinated polymer as an antimicrobial agent to manage the suppression and disinfection of pathogens.
IMPROVEMENTS IN WEIGHT CONTROL
Food scent substance for use in the treatment of obesity, wherein food scent from the food scent substance is inhaled from a device comprising the food scent substance.
A CONJUGATION LINKER CONTAINING 2,3-DIAMINOSUCCINYL GROUP
- Robert Yongxin Zhao ,
- Qingliang YANG ,
- Yuanyuan HUANG ,
- Linyao ZHAO ,
- Hangbo YE ,
- Xiaotao ZHUO ,
- Chengyu YANG ,
- Jun LEI ,
- Yifang XU ,
- Huihui GUO ,
- Wenjun LI ,
- Shun GAI ,
- Lu BAI ,
- Zhixiang GUO ,
- Junxiang JIA ,
- Jun ZHENG ,
- Xiaomai ZHOU ,
- Hongsheng XIE ,
- Qianqian TONG ,
- Mingjun CHAO ,
- Yanhong TONG ,
- Zhicang YE ,
- Chen LIN ,
- Yanlei YANG ,
- Binbin CHEN
The present invention relates to a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (a dual-linker) containing a 2,3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.