The disclosure relates to systems, methods and apparatus of storing, transporting, mixing, and injecting a drug as a solution, and in some embodiments, to a drug injection apparatus and system intended for use in mixing on demand a drug with a liquid, such as water, in a premeasured quantity and dosage, and injecting the drug mixture using an integrated hypodermic needle assembly. Also provided are methods of using such apparatus and systems.

A syringe holder includes: a barrel body that holds a syringe; a holder opening; deformation promoting portions; and radial movement-restricting portions. The radial movement-restricting portions are provided close to the deformation promoting portions. Being brought into contact with first portions, the radial movement-restricting portions restrict the syringe from moving in a radial direction with respect to the barrel body.

A safety mechanism syringe includes a syringe, a needle, a holder, and a needle cover displaceable relatively with respect to the syringe along an axial direction of the syringe from a use position toward a protection position. The holder includes a locking portion. At least one member of the holder and the needle cover includes a protruding portion that protrudes toward the other member, and the other member includes a restriction portion that abuts on the protruding portion to restrict relative displacement of the needle cover with respect to the syringe along the axial direction of the syringe from the protection position toward the use position.

A safety needle device is disclosed having a housing configured to couple to a syringe, the housing having a proximal end, a distal end, and a housing body. A first guide path, a second guide path and a third guide path may be disposed on the housing body. A needle hub is disposed on the proximal end of the housing and a needle cannula is attached to the needle hub. The device having a retractable sheath configured to move between an initial position, a retracted position and an extended position with respect to the housing, wherein the initial position partially exposes a distal tip of the needle cannula, the retracted position fully exposes the needle cannula, and the extended position fully covers the distal tip of the needle cannula. The retractable sheath also may have a guide element. The first, second and third guide paths are configured to slidingly receive the guide element. The device also having a first locking member, a second locking member, a rotating cam disposed in the housing body, and a spring element to bias the retractable sheath to an extended state to cover the distal end of the needle cannula upon completion of an injection.

An automatic injector dispenses a predetermined dose of medicament without a user having to manually force the needle into an injection site. The automatic injector includes a needle cover having a locked retracted position with respect to the injector housing prior to a medicament dispensing operation. The needle cover is operative to engage an injection site prior to a medicament dispensing operation.

A pen needle shield assembly comprising a hub fixed to a needle cannula, and a movable shield surrounding the hub, the movable shield comprising an upper portion having an outer diameter, a lower portion having an outer diameter greater than the outer diameter of the upper portion, and a distal opening, wherein the movable shield moves from a first position where the needle cannula is retracted in the movable shield prior to use, to a second position where the needle cannula is extended out of the movable shield through the distal opening for medication delivery and to a third position where the needle cannula is retracted in the movable shield and locked to prevent further use.

According to the invention a safety device for a pre-filled syringe comprises a substantially cylindrical and hollow support body and a hollow needle shield slideably arranged relative to the support body. The support body comprises at least one resilient arm and the hollow needle shield or a needle shield assembly comprises at least one curved actuation ramp. The curved actuation ramp protrudes in a lateral direction (L) perpendicular to a central axis (A) of the safety device. The curved actuation ramp comprises a first lateral dimension (L1) at a proximal end of the needle shield and a second lateral dimension (L2) exceeding the first lateral dimension (L1) at a distal end of the needle shield. The resilient arm engages the curved actuation ramp when the needle shield is slid relative to the support body.

A medicament delivery device is presented having a housing, a delivery member cover slidably arranged in the housing, a medicament container housing arranged in the housing, a forward-biased rotator structure configured to move the medicament container housing in a forward direction in the housing, wherein the delivery member cover is configured to be moved axially from an extended position relative to the housing to a retracted position, thereby causing the rotator structure to rotate from a first rotator position to a second rotator position, and a forward-biased plunger rod extending axially inside the rotator structure and having a first axial engagement position with the rotator structure when the rotator structure is in the first rotator position and the second rotator position, the rotator structure having a first rotator guide track structure configured to cooperate with an inner surface structure of the housing.

A needle protection assembly, adapted to protect a tip of a hypodermic needle, comprising a shield adapted, in a protected operative orientation of the needle protection assembly, to shield the tip of the hypodermic needle, a locking element including at least one slot, the slot including at least three surfaces corresponding to three operative orientations of the shield, at least one slot engaging element, functionally associated with the shield, the slot engaging element being disposed within the slot of the locking element and movable relative thereto, between the surfaces, so as to transition the shield between the three operative orientations, and at least one biasing element, adapted for axial biasing of the shield, wherein the three operative orientations include a storage operative orientation, an injection operative orientation, and a needle protection operative orientation.

A housing for a medicament delivery device is presented having a shell extending along an axis in an axial direction from a proximal end to a distal end, and a medicament delivery member guard moveably attached to the shell. The medicament delivery member guard extends in the axial direction from a proximal end to a distal end. The shell has a slit extending in the axial direction and the medicament delivery member guard has a protrusion extending in the axial direction, and/or the medicament delivery member guard has a slit extending in the axial direction and the shell has a protrusion extending in the axial direction. The medicament delivery member guard is configured to move in the axial direction from a first axial position relative to the shell (12) to a second axial position relative to the shell.