A device for injecting a therapeutic agent into an ocular implant at least partially implanted in an eye including an injection lumen providing a pathway for injecting the therapeutic agent into the implant; an outlet lumen providing a pathway for pre-existing fluid in the ocular implant to exit the implant; and a collection chamber fluidly coupled to the outlet lumen that provides a first fluid outflow resistance and a second fluid outflow resistance. The first fluid outflow resistance is lower than a first resistance to outflow of the implant. The second fluid outflow resistance is greater than a force imparted onto the implant by intraocular pressure of the eye. Injection of therapeutic agent into the implant via the injection lumen causes the pre-existing fluid to exit the implant and enter the collection chamber via the outlet lumen and causes a second pre-existing fluid to displace from the collection chamber.

The embodiments of the present disclosure provide a pierceable stopper, comprising a plug portion, and a disk portion disposed on top of the plug portion and comprising a flange extending radially beyond an outer diameter of the plug portion. The embodiments also provide a lyophilization stopper, comprising a body comprising an integral hinge means, and a flange extending radially beyond an outer diameter of the body. Additionally, the embodiments provide a probe assembly, comprising a first needle comprising a hollow cavity and a pointed tip, and a second needle disposed inside the hollow cavity and comprising a rounded tip. The embodiments further provide a cartridge assembly, comprising a first housing comprising a first set of cavities configured to accommodate one or more containers, and a second housing comprising a second set of cavities corresponding to the first set of cavities when the second housing is coupled to the first housing.

A cannula holder capable of securing a cannula to the holder at the time of piercing work, and easily removing the cannula from the holder using tweezers or the like. The cannula holder, to which a piercing needle for piercing an eyeball and a cannula are attached when attaching the cannula used in ophthalmic operations to the eyeball, includes claw portions that are formed on a front end of the cannula holder and which press sides of the cannula either at positions where said claw portions face each other or from multiple directions. A depression may be provided in a side of the front end of the cannula holder, allowing visibility of a part of a back end of the cannula from the depression.

The present invention relates to medicament injection devices (100). A cartridge (600) with a septum and a needle unit (500) having front and rear needles (510, 520) are configured for relative movement from a state where the septum is sealed to a state where the septum is pierced by the rear needle (520). The injection device (100) may include a needle shield (350) and be configured for piercing the septum by the rear needle (520) when the front needle (510) is operated relative to the needle shield (350). The injection device (100) may also include a damping mechanism configured for limiting the speed of movement of the cartridge relative to the needle unit. The injection device (100) may also include an indicator generating a signal when a piston driver has travelled the complete stroke length, wherein the indicator has a deflection element that is deflected prior to or during movement of the cartridge relative to the housing.

The present invention concerns an injection device for delivering a substance to the skin of a subject. The injection device is suitable for precise and even distribution of the substance to the skin and minimizing waste of injectable substance. The injection device comprises multiple cannulas, is connectable to standard syringes and particularly useful in dermatological treatments.

A needle structure for injecting a filler and monitoring a blood backflow situation simultaneously includes a needle, a housing and a partitioning member. The needle includes a needle chamber and a needle opening connected to the needle chamber. The housing includes a housing chamber and a housing opening connected to the housing chamber, and the housing chamber is connected to the needle chamber to form a needle housing chamber. The partitioning member is disposed in the needle housing chamber. The needle housing chamber is separated into a first chamber and a second chamber by the partitioning member. The needle opening is separated into an injection opening and a blood backflow opening by the partitioning member. The first chamber is connected to the injection opening, and the blood backflow opening and the housing opening are connected by the second chamber.

An epidural needle assembly including an epidural needle assembly and an injection needle assembly. The injection needle assembly is slidably mounted on the needle of the epidural needle assembly between extended and retracted positions. The injection needle assembly includes an injection hub having an injection needle secured thereto which extends forwardly therefrom. When the injection needle assembly is in its retracted position, the forward end of the injection needle is positioned rearwardly of the forward end of the epidural needle. When the injection needle assembly is in its extended position, the forward end of the injection needle is positioned forwardly of the forward end of the epidural needle. When in its extended position, the injection needle is able to create a hole in the skin of a person or animal to permit the epidural needle to be inserted therein.

Systems and methods for mitigating the formation of heterotopic ossification lesions by delivering a neuromuscular inhibitor employ a delivery device to distribute injection of the neuromuscular inhibitor. A delivery device for delivering the neuromuscular inhibitor can include an injector body, a device body for spacing the injector body from a target delivery location, and a plurality of needles; or can include an injector guide having multiple guide holes and an injector needle for delivering the neuromuscular inhibitor via the guide holes.

A trocar assembly wherein a trocar with an elongated polygonal tube can receive either an obturator or a medical instrument of a dissimilar cross-sectional shape with the medical instrument of the different cross sectional shape maintable in a central condition therein to inhibit pressure losses to lateral flow to thereby permit use of a cannula having a smaller cross sectional area than a cylindrical cannula as well as inhibit trauma to an entry site around the cannula.

A device for introducing a medicament 5 into a patient comprises a cannula 8 having an inlet end 12 for the medicament and a discharge end 14 for the medicament and a blood flow passageway 20 that provides a visual indication that the discharge end of the cannula is in a blood vein.