A method and a system for light-activated drug delivery. An optical probe is coupled to a tissue for transmitting light signals to the tissue for actuating and/or monitoring drug delivery with a multi-phase method for drug delivery. A first light signal is transmitted through the optical probe for actuating and/or monitoring the drug delivery and a second light signal having a different wavelength is transmitted, simultaneously with the first light signal, through the optical probe for actuating and/or monitoring the drug delivery.

A wearable health and lifestyle device including at least a measurement module configured to be worn by a user in at least a first wearing position, the measurement module comprising a 3-axis accelerometer unit configured to provide acceleration data and inclination data, a temperature measurement unit configured to provide temperature data, a light radiation measurement unit configured to provide light radiation data, said light radiation measurement unit comprising at least one multi-spectral sensor configured to measure wavelength bands over the range 290 nm to 1150 nm, a storage module configured to receive and store said acceleration data, said inclination data, said temperature data and said light radiation data, and an analysis module configured to analyze a data set comprising acceleration data, inclination data, temperature data and light radiation data.

A neural sensing system includes an interrogator that includes an optical head. The optical head is configured to transmit a light signal. The neural sensing system also includes a microprobe configured to contact tissue. The microprobe includes a transducer configured to receive the light signal and modulate the light signal with neural signal information sensed from the tissue. The microprobe also includes a retroreflector configured to reflect the modulated light signal back to the optical head of the interrogator.

The present disclosure relates to systems, methods, and uses of systems treating a skin condition with phototherapy. A system comprises (a) a phototherapy device comprising a phototherapy light source; (b) a patient computing device comprising a processor and a memory, the patient computing device configured to: transmit a first signal to the phototherapy device enabling operation of the phototherapy device according to one or more conditional prescription parameters, activate the phototherapy light source, and transmit a second signal reporting operation of the phototherapy device; and (c) a server configured to communicate with the patient computing device and receive the second signal. Also disclosed are systems, methods and compositions for controlling phototherapy treatments of the skin comprising (a) incorporating sun exposure into a prescribed phototherapy treatment; (b) quantitative measurement of erythema using digital image processing; (c) computer aided guidance for administration of targeted phototherapy; (d) treatment recommendations from outcome based analytics of a population of connected phototherapy devices; (e) an emollient with UV fading dye to visibly identify treated areas in the administration of targeted phototherapy.

Systems tune, control, or remediate the intrinsic Circadian clock. A light controller sets spectral distribution, intensity of a bioactive spectral band to shift or entrain circadian response to enhance performance and/or synchronize with local or expected conditions. The systems enhance performance under conditions that might be changing, disrupted, or otherwise present an irregular phase or unnatural change in the subject's circadian status, for example, due to geographically discontinuous activity or spectrally deficient workplace illumination, or due to divergent individual sleep/wake behaviors of subjects in a structured group activity. An illumination recipe that compensates for the deficiency of lighting or of participant sleep or behavior patterns, or age- or disease-related changes, to evoke, shift, or align circadian response and improve behaviors such as classroom alertness, relaxation, excitability, attention, or focus. Systems may receive sensed light values and automatically apply high- and/or low-CER illumination to effect the intended circadian phase.

An optical stimulation system includes a light source configured to produce light for optical stimulation; a light monitor; an optical lead coupled, or coupleable, to the light source and the light monitor; and a control module coupled, or coupleable, to the light source and the light monitor. The control module includes a memory, and a processor coupled to the memory and configured for receiving a request for verification or measurement of a light output value; in response to the request, receiving, from the light monitor, a measurement of light generated by the light source; and, based on the measurement, reporting a response to the request.

Systems and methods are described for treatment of neurological conditions in which transcranial illumination using infrared, near-infrared and/or red wavelengths of light are delivered into the brain of a patient using a portable head wearable device. Arrays of light emitters are simultaneously controlled to provide a selected power density and distribution during a therapeutic session to treat a condition of the patient. An external controller such as a touchscreen tablet or laptop computer can be used to select illumination parameters for each patient. The system can be used to provide treatment to children such as those having autism spectrum disorder (ASD).

A method for evaluating the effectiveness of a skin treatment on a skin feature includes correcting the color of a first image before the skin treatment, correcting the color of a second image after the skin treatment, determining the sizes of the skin feature in the first and second images, and comparing the corrected colors and sizes of the skin feature in the first and second images. In some embodiments, the first and second images include the skin feature and an indicator adjacent to the skin feature, where the indicator has a standard color and a known size.

A stimulation system includes an energy source, an electronics unit with a controller, and an actuator that is coupled with the electronics unit and/or the energy source. The actuator emits electromagnetic waves for stimulation of genetically manipulated tissue. The electronics unit is disposed in a housing. The stimulation system is configured for at least temporary implantation in a human or animal body. The controller controls the stimulation of tissue in the body by way of the electromagnetic waves emitted by the actuator. A selector of the stimulation system selects the area of the said tissue for stimulation. The selector includes a masking device for masking certain areas of the tissue, so that an intensity of the stimulation for the masked areas is reduced or equal to zero.

Periodontal disorders such as disorders associated with a dental implant are treated. An average power for a laser is selected via a user interface on a tablet, along with a set of permissible laser parameters provided in response to the selected average power. A gingival trough or flap is created around the implant with the laser. Infected tissue is selectively ablated or denatured via photothermolysis, and a pocket is lased around the affected implant. Marginal tissues are compressed against the implant.